Dubai Final-v20.indd - World Allergy Organization

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ABstrACts ABstrACts regulates igE production and eosinophile count in patients who show 1-3 times wheeze after life, and has likely action to improve wheeze expression clinically. 3309 EValUaTion oF Small airWaYS oF JaPanESE CHilDHooD aSTHma BY HrCT anD iTS aSSoCiaTion WiTH SnPS tomikawa, m. 1 , Oguma, t. 2 , niimi, A. 2 , matsui, E. 3 , Kondo, n. 3 and Ebisawa, m. 1 1 2 Pediatrics, sagamihara national Hospital, sagamihara, Japan. respiratory medicine, graduate school of medicine, Kyoto University, Kyoto, Japan. 3Pediatrics, graduate school of medicine gifu University, gifu, Japan. Objectives: the purposes of these studies were to evaluate small airways in childhood asthma by high-resolution computed tomography (HrCt) and to examine the association of single nucleotide polymorphisms (snPs) with small airways’ obstruction. methods: ten asthmatic patients (6 males & 4 Females) treated with iCs were recruited to the evaluation of small airways. By using HrCt, low attenuation area (lAA) % and mean lung density (mlD) % were examined. ninety three patients (70 males & 23 females) were recruited to snPs study and were divided into %FEF50%≥80% group (n=34) and %FEF50%
ABstrACts autumn only in 13% of cases in spring and summer in 12 % of cases. the Pt was positive in 93% of cases, sensitization to dust mites is in first place (67%) followed by the olive tree (32%), cypress (29%), Parietaria (22%), 5 grasses (21%) , Alternaria (25%), dog (20%), cat (15%) and cockroach (15%). the monsensibisation was found in 20% of cases, the majority were polysensitized with mites. Discussion - comments: the mites are the main aero-allergen, in accordance with literature data. sensitization to pollen occupies the second place, this may be related with age bracket included in the study (children over 4 years). We note an important awareness to mold. Polysensitization is often encountered in older children. in some cases, there was a discrepancy between the history and results of skin prick tests based research to discuss specific igE. Conclusion: the diagnosis is mainly clinical allergy. the examination and skin tests constitute the cornerstone. they are sufficient in most cases to diagnose the cause. Clinical common sense and prudence of the findings are required in the interpretation of results. 3312 THE rolE oF CHiTinaSE-liKE ProTEinS in allErgiC inFlammaTion on PEDiaTriC aDEnoiD TiSSUE shin, s. 1 , Ye, Y. 2 , lee, K. 1 , Kim, s. 1 , Cho, J. 1 and Park, H. 2 1 2 Otorhinolaryngology-Head and neck surgery, Kyung Hee University, seoul, south Korea. Department of <strong>Allergy</strong> & rheumatology, Ajou University school of medicine, suwon, south Korea. Chitin is an essential structural component of the fungal cell wall and is present in the exoskeleton of arthropods and the microfilarial sheath of nematodes. recent findings have not only demonstrated that mammals produce chitinases, but also that increased secretion of chitinases is closely associated with th2-dominated pathophysiological conditions including infection, fibrosis, allergy and asthma. the purpose of this study is to measure the level of chitinase-like proteins (ClPs) in adenoid tissues from atopic children, and to know its role in allergic inflammation on pediatric adenoid tissues. Forty atopic subjects, who were sensitized to more than one common aeroallergen, and 40 non-atopic subjects undergoing adenotonsillectomy, were recruited. the level of ClPs was measured by ElisA. immunoassays using adenoid tissue homogenate were performed to quantify the levels of total igE, eosinophil cationic protein (ECP), mast cell tryptase and Alternaria-specific igE. median level of ClPs was tend to be higher in atopics than in non-atopics (p = 0.056). median level of ECP was significantly higher in atopics than in non-atopics (p < 0.001), while no difference was seen in tryptase. the level of ClPs in adenoid tissues strongly correlated with ECP or tryptase level. in addition, median level of ClPs was significantly higher in children showing positive response for Alternaria-specific igE than in children with negative response. in conclusion, chitinase showed close relationships with ECP or tryptase in allergic inflammation on pediatric adenoid tissues, and increased locally in fungal allergen sensitized children. 3313 PaSSiVE SmoKing iS a maJor DETErminanT oF EXHalED niTriC oXiDE lEVElS in allErgiC aSTHmaTiC CHilDrEn laoudi, Y. 1 , nikasinovic, l. 2 , sahraoui, F. 1 , grimfeld, A. 1 , momas, i. 2 and Just, J. 1 1 2 Department of Asthma and Allergic Diseases, Armand trouseau Children University Hospital, Paris, France. laboratory of Public health and Environment, Faculté des sciences Pharmaceutiques et Biologiques, Université Paris-Descartes, EA 4064, Paris, France. Background: Fraction of exhaled nitric oxide (FenO), as a reflection of allergic bronchial inflammation, is considered to be a treatment follow-up parameter in allergic asthmatics. Factors such as active smoking can, however, influence FenO measurement and are thus taken into account in the interpretation of this parameter. in children, the evidence in favor of an impact of passive smoking (Ps) on FenO measurement is controversial. objective: to evaluate the impact of Ps on measurement of FenO in allergic asthmatic children. methods: 70 non-treated allergic asthmatic children over the age of 5 years underwent phenotype characterisation by measurement of on-line FenO, spirometry, and allergic tests (skin prick tests, total and specific igE levels, blood eosinophilia). Children were considered to be exposed to Ps when at least 5 cigarettes per day were declared by the family to be smoked at home. results: mean FenO in 48 children unexposed to Ps was 62.3 ± 29.1 ppb versus 30.3 ±17.6 ppb in 22 exposed children (p
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Final Program 5-8 December 2010 •
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CO COImportant Dates 30 June 2011 E
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WAO IntErnAtIOnAl ScIEntIfIc cOnfEr
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ABstrACts results: the prevalence o
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ABstrACts effective diagnosis and e
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ABstrACts mWCnts on OVA-asthma mode
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ABstrACts allergy in human. A Burka
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ABstrACts Patients with all negativ
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ABstrACts both gender, suggesting a
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ABstrACts 1208 THE rolE oF inTErlEU
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ABstrACts of oral steroids in last
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ABstrACts 1215 aSTHma ComPliCaTion
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ABstrACts to allergens, lower sever
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ABstrACts 1301 non-EoSinoPHiliC aST
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ABstrACts participated in this stud
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ABstrACts for attacks of shortness
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