Dubai Final-v20.indd - World Allergy Organization

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cases were positive for hmPV. HmVP prevalence among male was three times greater than female. All of the positive hmPV children
were affected by wheezing. more over 31.3% were simultaneously affected by wheezing and asthma. significant correlation
between clinical manifestation and more than 2 days of hospitalization and positivity of hmPV were detected.
Conclusion: HmPV prevalence in children with asthma and wheezing was almost the same in shiraz in compare with the other part
of the world. recent findindgs suggest a probable role of hmPV in asthma exacerbation and wheezing onset.
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SEroPrEValEnCE oF aniSaKiaSiS analiSYS rESiDEnTS From “alDEa DE PESCaDorES” ToWn, PUErTo la CrUZ,
anZoaTEgUi 2010
naime, m. , sofia, m. and Elizabeth, P.
Escuela De Ciencias De la salud, Universidad de oriente, Puerto la Cruz, Venezuela.
Anisakiosis is a zoonosis caused by nematodes Anisakidae family, of which there are many genres distinguished by their public
health concern as: Pseudoterranova, Contracaecum, Hysterothylacium and Anisakis. Furthermore, there are four species recognized
from Anisakis: A. simplex, A. physeris, A. typical and A. schupakovi. Anisakis simplex is being the most studied parasite in clinical
practice, parasitizing marine mammals in its adult form, and in different larval stages affects fish and cephalopods. the humans,
being an accidental host, it is acquired through the consumption of raw or undercooked fish. Anisakiosis could be a public health
problem, especially in areas where the economy and feeding depend on fishing, causing health problems for the whole community.
objectives: analyze the seroprevalence of anisakiasis in residents from “Aldea de Pescadores” town, sector i, Puerto la Cruz,
Anzoátegui state. materials and methods: it was conducted an exploratory, field, prospective, cross-sectional research. there
were taken samples of 93 local people from “Aldea de Pescadores” which were tested by Prick test and specific igE determination
in order to detect positive Anisakiosis cases, to carried out a hypothesis test, analyzed by sPss 17.0. results: there was a (8.6%)
of positive prick test to Anisakis simplex; 6.5% for the specific igE determination to the same parasite. However, verified the null
hypothesis there were no differences in the prevalence of gastrointestinal, dermatological and/or breathing symptoms in those with
skin and serological positive tests for Anisakis simplex. Conclusions: the results indicate that the Anisakis simplex infection is not
a public health problem in “Aldea de Pescadores” town. nevertheless, there are a positive percentage of Anisakiasis cases in this
town. For this reason, it is necessary the spread of information, and the application of prophylactic measures to avoid the increasing
number of people affected by this disease.
Keywords: Anisakiasis, Prick test, igE, Anisakis simplex.
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EFFECTS oF VarioUS rESPiraTorY VirUSES on DEr F-SEnSiTiZED moUSE moDEl oF aSTHma
Kim, H. H. , Chun, Y. H. , Yoon, J. , Kim, J. t. and lee, J. s.
Pediatrics, the Catholic University of Korea, Pucheon-si, south Korea.
Purpose: respiratory viral infection is the main cause of acute asthma exacerbation in children and can be a confirmed viral
infection in 85% of children who visit a hospital because of asthma exacerbation. Viruses related to acute asthma exacerbation are
rhinovirus (rV), respiratory syncytial virus (rsV), parainfluenza virus (PiV), human metapneumovirus (hmPV) and influenza virus.
Among the viruses, rV is the most well-known frequent cause virus of acute asthma exacerbation for children 2 years or more.
some in vitro studies showed the immunologic responses after rV infection were different from other respiratory viruses. this
may refer that the response to rV infection can be different to other respiratory viruses in patients with asthma. in this experiment,
we determined cell counts and the level of cytokines in bronchoalveolar lavage fluid (BAlF) of asthma mouse model after being
infected by rV, rsV, or influenza virus in order to evaluate that there are differences in the kind of virus.
methods: Asthma mouse model is made by sensitizing BAlB/c mouse to house dust allergen Der f. the asthma mouse model is
confirmed by measuring the airway resistance caused by methacholin inhalation, the eosinophil counts, interleukin (il)-4, il-5 and
il-13 in BAlF, and by observing peribronchial eosinophilic inflammation of lung tissue through a microscope. After the prepared
asthma mouse model is infected by rV, rsV, and the influenza virus respectively, the rt-PCr is used to confirm the existence of
virus genes in lung tissue. We determined the number of eosinophils, neutrophils, lymphocytes and macrophages in BAlF and
measured rAntEs and inF-γ in BAlF of the mice infected by the viruses.
results in the case of the Der f-sensitized mouse model with rV infection, the airway resistance and eosinophil counts in BAlF
increased, and inF-γ level did not increase by the virus. these findings were different from in the case of rsV or influenza virus
infection.
Conclusion: in the case of infecting a respiratory virus to the developed asthma mouse model with the sensitized house dust mite
allergen, increased airway resistance and eosinophilic inflammation with no increase in th1 response were shown only with rV.
these findings can be related to the phenomenon that rV is most frequently found to be the cause of acute asthma exacerbation.
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