Dubai Final-v20.indd - World Allergy Organization

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uptake, dominated the disease with medium-severe course. Conclusion: Epidemiological studies can provide reliable information
on the prevalence, structure and severity of AD. monitoring of the true prevalence of AD shows hypodiagnostics of all forms of AD in
the Cis-C, related to the underestimation of mild forms of the disease. Accounting for the structure and expression of sensitization
to allergens, taking into account climate and geographic features, allows to plan the work of allergic services and to organize
preventive and curative interventions.
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gUiDElinES aPPliCaTion For aSTHma anD rHiniTiS managEmEnT: arga (rESPiraTorY allErgiC DiSEaSES:
moniToring STUDY oF gina anD aria gUiDElinES) ProJECT
Baldacci, s. 1 , maio, s. 1 , Cerrai, s. 1 , sarno, g. 1 , Borbotti, m. 1 , Angino, A. 1 , martini, F. 1 , Carrozzi, l. 1 , Di Pede, F. 1 and Viegi, g. 2
1 2 institute of Clinical Physiology, national research Council, Pisa, italy. Cnr institute of Biomedicine and molecular immunology,
Palermo, italy.
Background: in italy, a big effort has been made to disseminate ginA and AriA guidelines (gl) for asthma and rhinitis management
within the setting of specialist and general practice. Despite a general good knowledge of gl, their implementation within the
clinical practice seems still poor.
Objective: to assess the level of application of gl for asthma and rhinitis management within general practitioners (gP).
methods: cross-sectional italian survey (2007-10); 107 gP (89% of the expected sample) enrolled patients with asthma/rhinitis
diagnosis and pharmacologic treatment and/or rhinitis/asthma symptoms in the last 12 months.
For each patient (n=1820), a questionnaire was filled in by gPs on: diagnosis of allergopathies, asthma and rhinitis severity
according to gl, instrumental tests used for diagnosis/monitoring, educational activity, drug prescriptions for asthma/rhinitis.
results: patients are: 47% rhinitic (7% moderate-severe persistent), 25% asthmatics (2% severe persistent) 28% with both asthma
and rhinitis (Ar) (8% with moderate-severe persistent rhinitis, 6% with severe persistent asthma).
the prevalence of prescribed instrumental tests for rhinitis diagnosis/monitoring ranges between 32% (objective nasal test) and
62% (prick test) while for asthma is between 6% (exhaled nitric oxide) and 87% (spirometry). Ar increases the prevalence of
prescribed instrumental tests for rhinitis and decreases that for asthma instrumental investigations.
58% of rhinitic patients, 68% of asthmatics and 68% of Ar subjects receive a specific education (regular controls, written
therapeutic plans, auto-monitoring education, support groups). 35% of rhinitic, 29% of asthmatics and 26% of Ar patients receive
general information. 6% of rhinitic, 3% of asthmatics and 5% of Ar patients do not receive any educational intervention.
Considering the prescribed pharmaco-therapeutic categories, 43% of rhinitic, 77% of asthmatic and 54% of Ar subjects do not
receive an appropriate treatment in relation to the severity level.
Conclusions: contrary to gl recommendations, use of instrumental tests for asthma and rhinitis diagnosis/monitoring appears still
incomplete as well as use of specific educational support for the patients. Anyway, it is the pharmacologic treatment for rhinitis and
even more for asthma that presents the lower level of implementation within the general practice.
Work supported by the italian medicines Agency (AiFA), contract no. FArm5JYs5A.
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inHalED SoDiUm CromoglYCaTE rEDUCES THE EXPrESSion oF aSTHma-rElEVanT CYToKinES BY PEriPHEral BlooD T
CEll in CHilD aSTHma. THiS SUPPorTS iTS PoSSiBlE USE aS PrEVEnTaTiVE THEraPY in CHilD aSTHma
gemou-Engesaeth, V. 1 , Hamid, Q. 2 , roedland, E. A. 3 , Heier, H. E. 4 , gaarder, P. i. 4 , grogaard, J. B. 1 , Halvorsen, s. 1 and Corrigan, C. J. 5
11Dept. of Pediatrics, Oslo Univers. Hospital5King’s College london school of medicine and 6Athens University, A Pediatric Clinic,
Oslo, norway. 2mcgill University, meakins-Christie laboratories, montreal, QC, Canada. 33institute of medical microbiology,
rikshospitalet, molecular Biology, Oslo, norway. 4Dept. of immunology and transfussion medicine, Oslo University Hospital, Oslo,
norway. 5Centre for Allergic mechanisms of Asthma, King’s College london school of medicine and mrC and Asthma, Centre for
Allergic mechanisms of Asthma, london, United Kingdom.
We addressed the in vivo anti-inflammatory effects of inhaled sodium cromoglycate (sCg) in childhood asthma. Ethical approval
was granted by the regional ethics committee. All patients and their parents received written information concerning the purpose of
the study, and parents provided written consent.
seven asthmatic children aged 7-13 years needing regular preventative therapy for the first time for asthma control were followed
for 4-6 (mean 4.8) months after commencing sCg at a dosage of 10 mg 4 times daily by metered-dose inhaler. Just prior to
commencing therapy and at the end of follow-up, CD4 and CD8 t cells were isolated from peripheral blood samples and the
percentages of these cells expressing mrnA encoding interleukin-4 (il-4) and il-5 determined using in situ hybridisation with
specific, anti-sense riboprobes. Clinical improvement was accompanied by significant reductions in the percentages of peripheral
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