Dubai Final-v20.indd - World Allergy Organization

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therapy. However, patient defaulted followed up on and off after that. Eight years later during followed up at the paediateric clinic,
a doctor noted that the patient not only having learning difficulty but also recurrent chest infection for the past 2 years. there was
also presence of unsteady gait, telangiectasia at the conjunctivae, nystagmus, multiple healed infected skin lesion, generalized
crepitations in both lungs and positive cerebellar sign. serum iggAm was 8.8/5.63/2.09 g/l. Based on the patient complaint and
physical findings, the final the diagnosis of ataxia telangiectasia was made.
2101
CHroniC EoSinoPHiliC PnEUmonia in PaTiEnT WiTH DiFFiCUlT-To-TrEaT aSTHma
Pauk, n.
3rd Faculty of Charles University, Dept of Pneumology, Faculty Hospital na Bulovce, Prague, Czech republic.
introduction
idiopathic chronic eosinophilic pneumonia (iCEP) is a rare disorder of unknown cause characterised by subacute or chronic
respiratory and general symptoms, alveolar and /or blood eosinophilia, and peripheral pulmonary infiltrates on chest imaging .
interestingly, some but not all patients diagnosed with iCEP have a history of asthma, whilst others may develop asthma after a
dignosis of iCEP has been made.
Case presentation
An 66-year-old woman with a history of asthma and chronic rhinitis with polyps , nonsmoker, history of allergies negative, formerly
farming work..
she received antiasthmatic treatment with salmeterol/fluticasone propionate (50/500) bid since 2005, no other drugs. she suffered
from frequent exacerbations of asthma .On 1st .of september 2006 she had sudden fever, weight loss, malaise and impaired
dyspnea with productive cough, mild chest pain on sternum and respiratory failure. A chest radiograph demonstrated bibasilar
infiltrates.
Peripheral blood smear showed a newly developed, marked eosinophilia (20%), and a chest X-rays and HrCt scan revealed a
diffuse patchy nodular infiltrate in all lung fields.
Discussion
We present this case, because iCEP is a rare complication of asthma, although it is seldom mentioned in reviews ant textbooks on
asthma. Asthma in patients with iCEP is relatively severe and get worse after diagnosis of iCEP .
the presence of asthma at the time of diagnosis of iCEP, is associated with less relapses of iCEP, possibly because of a higher
frequency of long-term inhaled corticosteroids use in asthmatics .
in our case no clinical relevant relaps of iCEP has occurred during 4-year follow-up.
Conclusion
Clinicians should consider pulmonary eosinophilia in the differential diagnosis of patients treated for asthma who develop
pulmonary infiltrates with dyspnea.
2102
CliniCal CHaraCTEriSTiCS oF EoSinoPHiliC organ inVolVEmEnT DiSTingUiSHing From mETaSTaSiS in CanCEr
PaTiEnTS WiTH EoSinoPHilia
Kim, t. , lee, t. , lee, Y. s. , Bae, Y. , Cho, Y. s. and moon, H.
Department of Allergy and Clinical immunology, Asan medical Center, University of Ulsan College of medicine, seoul, south Korea.
Background: Eosinophilic organ involvement should be differentiated from metastasis of primary cancer, when space occupying
lesions were newly developed together with peripheral blood eosinophilia in a patient who has been diagnosed with cancer,
because further chemotherapy may be needed.
objective: to investigate clinical characteristics of eosinophilic organ involvement compared with distant metastasis in patients
with primary cancer.
methods: We retrospectively reviewed medical records of thirty cancer patients who newly developed hepatic or pulmonary
nodules with peripheral blood eosinophilia from January, 2005 to February, 2010 in Asan medical Center in seoul. Eosinophilic
infiltration or distant metastasis was defined by pathologic findings and radiologic features. mann-Whitney U test or Kruskal-Wallis
test were used for statistical analysis.
results: twenty patients (66%) were diagnosed with eosinophilic infiltration, 5 (17%) with cancer metastasis, and 5 (17%)
with undetermined. History of raw food diet, high serum levels of total igE, normal liver function test, fewer and smaller nodules
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