Dubai Final-v20.indd - World Allergy Organization

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1404
EFFiCaCY oF FEXoFEnaDinE in DiFFErEnT DoSagES For TrEaTmnET oF SEaSonal allErgiC rHiniTiS
Eatemadi, A.
immunology & infectious disease, Ahvaz univrsity of medical siences, Ahvaz, iran.
Background: the aim of this study was to determine the efficacy of fexofenadine in different dosages for treatment of seasonal
allergic rhinitis ( sAr).method: A placebo-controlled, double blind study was conducted in 114 patients with diagnosis of sAr.
they were randomly assigned to received either 60 mg, 120 mg , 180 mg once daily fexofenadine or placebo for one month.
Patients were evaluated by using total symptom score ( tss ) and total nasal score ( tns ) during and at the end of treatment.
results: Fexofenadine 120-180 mg was significantly more effective than placebo for improvement of sAr signs and symptoms.
no statistically significant difference was seen between two dosages ( 120 mg vs. 180 mg ). Conclusion: Once dail 120 mg
fexofenadine is an effective and safe treatment for seasonal allergic rhinitis.
1405
THE moDiFiED SnoT-20 QUESTionnairE: rEPEaTaBiliTY anD aPPliCaBiliTY To rHiniTiS
sami, A. s.
Ent, royal national throat, nose and Ear Hospital, london, United Kingdom.
Background
rhinitis is a clinically prevalent disease, symptomatically characterised by nasal itch, sneezing and difficulty breathing through the
nose. Patients with rhinitis often suffer from associated symptoms related to posterior nasal, sinus and ear disease. Other effects on
the psychological well being are also accountable to rhinitis.
A number of these features are encompassed in disease specific quality of life (Qol) questionnaires. However, the modified snOt-
20 (msnOt-20) questionnaire aims to correspond to the requirements for a complete and comprehensive assessment of rhinitis
and its impact. it uses a six-point scale to identify clinical severity (0=no problem, 5=very severe problem). method
the msnOt-20 questionnaire was evaluated in a pilot study of disease and non-disease and then used to assess the prevalence of
rhinitis and associated features in a community based survey. Following a successful pilot project, 2000 postal questionnaires were
sent to randomly selected adults from the electoral register in Farnborough. Differences in housing, social class and environment
were balanced with repeat questionnaires sent for non-respondents. results
in the pilot study, there were significant differences (p < 0.001) in symptom reporting between rhinitics and non-rhinitics, with
92.67% of the healthy controls responding on all 20 questions either 0=no problem (85.67%) or 1=very mild problems (7%) in
comparison to 42.07 % in the rhinitis group (28.7 % of responses no problem, 13 % very mild problems). A score of 0 or 1 was thus
taken as normal and 2-5 taken as abnormal.
in the community survey in Farnborough, 68% of 1580 evaluable respondents (79.8 % response rate) had a total snOt-20 score of
0-20 (max 100) with 32% scoring 21 + (max 88). there were significant correlations between the rhinitis domain and the 4 other
domains (paranasal [sinus and ear], sleep, social and emotional). the repeatability of these responses was evaluated in a follow-up
evaluation in a subpopulation. Conclusion
msnOt-20 questionnaire is a disease-related Qol rhinitis questionnaire, which is valid for the evaluation of rhinitis and the impact
of disease on quality of life. it identified a high prevalence of nasal and paranasal problems within the community with significant
co-morbidity caused by rhinitis.
1406
a CommUniTY BaSED SUrVEY on THE PrEValEnCE oF rHiniTiS
sami, A. s.
Ent, royal national throat, nose and Ear Hospital, london, United Kingdom.
Background
rhinitis is an increasingly common condition although there is limited information as to its true prevalence within the community.
this study aimed to obtain a current prevalence of rhinitis within the community and to explore its impact on social and emotional
functioning. A survey of 2000 adults in the Farnborough area was devised and carried out using the modified snOt-20 (msnOt-20)
questionnaire for this study.
method
A postal survey of rhinitis was conducted in the Farnborough area with 2000 msnOt-20 questionnaires being sent to randomly
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