Dubai Final-v20.indd - World Allergy Organization

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that when Ds within the scope of 0.2–0.5 and the M w in the range of 40–50 kDa, slBP exhibited significantly strong inhibition of
HiV activity, and it was confirmed by real-time biomolecular interaction analysis (BiAcore). the optimum sulfation conditions were
reaction temperature of 45°C, the molar ratio of Py-sO 3 to lBP of 2:1 and the reaction time of 6 min at the microwave power of
45W in DmF.
2106
THE lEVEl oF THE TUmor nECroSiS FaCTor in PaTiEnTS WiTH FEmoral nECK FraCTUrES
Popova, O. 1 , nurpeisov , t. 2 and Batpenov , n. 3
1 2 laboratory, research institute of traumatology and orthopedy, Astana, Kazakhstan. research institute of Cardiology, Almaty,
Kazakhstan. 3research institute of traumotology and orthopedy, Astana, Kazakhstan.
Methods: We have investigated the dynamics of the tnF level in patients with femoral neck osteoporotic fractures. the main group
of 132 patients aged 60–75 with fractures of the proximal section of the neck of femur and the controlling group of 78 patients of
the same age without the fracture were the object of our investigation.
Results: in assessing the tnF-a serum level in patients with femoral neck osteoporotic fractures we revealed its trustworthy
growth. in the group of patients with femoral neck osteoporotic fractures we observed a sharp increase of tnF-a concentration
(93,8 ± 5,9 pg/ml) which exceeded the indices of the controlling group of patients by 3,4 times (r < 0,5). the investigation of the
tnF-a serum level before the operation in patients with femoral neck osteoporotic fractures according to the type of the fracture in
comparison with the controlling group made it possible to state that the content of this cytokine in all the patients was heightened.
the highest indices were recorded in patients with subcapital femoral neck fractures.
Conclusions: We have revealed high rates of tnF-a in patients with femoral neck osteoporotic fractures which exceeded the
indices of the controlling group of patients by 3,4 times (r < 0,5). moreover, during the first 24 hours after the operation a higher
level was found in the group of patients with subcapital and pertrochanteric femoral neck fractures. later, on the 14-th day after the
operation, we observed the tendency to reduction of the tnF-a rate by 1,4 and 2,1 times, accordingly. On the contrary, in patients
with spit and transcervical fractures the tnF-a level reduced during the first 24 hours, but there was a tendency to augmentation
on the 14-th day by 0,8 and 0,7 times, accordingly. the obtained data can serve as a prognostic criterion of the emergence of
postoperative complications and the course of treatment.
2107
STUDY oF il-8 inDiCES in ElDErlY PEoPlE WiTH FEmoral nECK FraCTUrES
Popova, O. 1 and nurpeisov , t. 2
1 2 laboratory, research institute of traumatology and Orthopedy, Astana, Kazakhstan, Astana, Kazakhstan. research institute of
Cardiology, Almary, Kazakhstan.
this study the dynamics of il-8 rate in patients with osteoporotic femoral neck fractures (a group of patients with subcapital and
pertrochanteric fractures).
the level of il-8 has been studied in 112 patients with osteoporotic fractures of proximal one-third of femoral neck. in the group
with subcapital fractures we have revealed a high concentration of il- 8, which exceeded the controlling group indices by 1.2 times.
il-8 indices in the group of patients with pertrochanteric fractures have not reached statistically significant distinctions.
During the first 24 post-operation hours we have observed in the group of patients with subcapital fractures a growth of il- 8 rate
by 1,2 times (p > 0,05) in comparison with that before the operation. no significant difference with its content was revealed in
patients with pertrochateric fractures as compared with the controlling group.
By the 14th day there was registered a tendency to the further growth of il–8 indices up to 4,2 pg / ml, which was by 1,8 times
higher than the level before the operation (p > 0,05). On the contrary, there was an il-8 decline to the lower level registered in the
group with pertrochanteric fractures as compared to the controlling group indices (1,7 pg / ml).
According to our research, patients with subcapital fractures of the neck of the femur proved to be the most vulnerable elderly
patients. We have also registered the highest percentage of post-operation complications and a more lingering rehabilitation period
in this group of patients. it should be noted that women showed higher il-8 indices (2,15 pg/ml), which were by 1,1 times higher
than those of the controlling group.
it has been determined that during the first post-operation day the il-8 level exceeded the indices of the controlling group by 1,6
times and on the 14-th day the elevation was by 2,2 times higher, which amounted 2,93pg/ml and 4,2pg/ml accordingly. the fact
in question may serve as a diagnostic criterion for the development, diagnosing and treatment of osteoporotic fractures in older and
senile patients.
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