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Physical fitness training for stroke patients (Review) - Update Software

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data were, however, confounded by additional <strong>training</strong> time. After<br />

removal of these data from the analysis no significant <strong>training</strong><br />

effect was evident (MD -1.13 seconds, 95% CI -2.91 to 0.65)<br />

(Analysis 5.27). Follow-up data from the two unconfounded trials<br />

(Mead 2007; Richards 2004) did not show a significant retention<br />

of mixed <strong>training</strong> benefits (Analysis 6.15).<br />

One trial assessed upper extremity functional per<strong>for</strong>mance using<br />

the nine hole peg test (<strong>for</strong> fine motor coordination) and the Action<br />

Research Arm test (Donaldson 2009). No significant <strong>training</strong><br />

effects were observed in either test at the end of intervention<br />

(Analysis 5.24; Analysis 5.25).<br />

Health status and quality of life<br />

Cardiorespiratory <strong>training</strong> (Comparisons 1 and 2)<br />

Only one trial assessed the effects of cardiorespiratory <strong>training</strong><br />

on measures of quality of life, in 28 participants (Aidar 2007).<br />

Both the SF-36 physical component score and the SF-36 emotion<br />

score were significantly better at the end of the <strong>training</strong> period in<br />

participants who underwent cardiorespiratory <strong>training</strong> (Analysis<br />

1.22; Analysis 1.23).<br />

Resistance <strong>training</strong> (Comparisons 3 and 4)<br />

One small trial of 20 participants (Kim 2001) did not show any<br />

significant differences between the resistance <strong>training</strong> group and<br />

the control group in either the physical health or mental health<br />

component of the SF-36 at the end of intervention (Analysis 3.10;<br />

Analysis 3.11).<br />

Mixed <strong>training</strong> (Comparisons 5 and 6)<br />

One trial (Cooke 2010) measured the effects of mixed <strong>training</strong><br />

on quality of life in 50 participants using two components of the<br />

EuroQuol scale. Scores were not significantly different between<br />

intervention groups at the end of the <strong>training</strong> phase (Analysis 5.28;<br />

Analysis 5.29) or at follow-up (Analysis 6.16; Analysis 6.17).<br />

A few trials assessed the effects of mixed <strong>training</strong> on quality of<br />

life using different components of the SF-36 survey questionnaire.<br />

In two trials with a total of 112 participants (Duncan 2003;<br />

James 2002) significantly better scores were obtained in the SF-36<br />

physical functioning component in the mixed <strong>training</strong> group at the<br />

end of intervention (SMD 0.48, 95% CI 0.10 to 0.85) (Analysis<br />

5.30) but not in the social role functioning component (Analysis<br />

5.31). Three trials with a total of 178 participants (Duncan 2003;<br />

James 2002; Mead 2007) showed significantly better scores in the<br />

SF-36 physical role functioning <strong>for</strong> the mixed <strong>training</strong> group at the<br />

end of intervention (SMD 0.56, 95% CI 0.26 to 0.86) (Analysis<br />

5.32). This effect was retained at follow-up (Analysis 6.19).<br />

One trial (Duncan 2003) showed that participants receiving mixed<br />

<strong>training</strong> had significantly better results in the emotional role functioning<br />

component of the SF-36 compared with controls at the<br />

end of the <strong>training</strong> period (Analysis 5.33) but not at follow-up<br />

(Analysis 6.20).<br />

It is worth noting that in the Duncan 2003 and James 2002 trials<br />

the intervention group was potentially confounded by additional<br />

<strong>training</strong> time.<br />

Mood<br />

<strong>Physical</strong> <strong>fitness</strong> <strong>training</strong> <strong>for</strong> <strong>stroke</strong> <strong>patients</strong> (<strong>Review</strong>)<br />

Copyright © 2011 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.<br />

Cardiorespiratory <strong>training</strong> (Comparisons 1 and 2)<br />

One trial (Smith 2008) assessed the potential benefits of cardiorespiratory<br />

<strong>training</strong> on depression symptoms using the Beck Depression<br />

Index. No significant differences were found between intervention<br />

groups at the end of intervention (Analysis 1.24) and at<br />

follow-up (Analysis 2.16).<br />

One trial (Bateman 2001) assessed participants using the anxiety<br />

and depression components of the Hospital Anxiety and Depression<br />

Scale (HADS). The anxiety score decreased immediately after<br />

cardiorespiratory <strong>training</strong> (MD -1.94, 95% CI -3.80 to 0.08)<br />

(Analysis 1.25) but this small benefit was not retained at the followup<br />

assessment (Analysis 2.17). In contrast, the depression score<br />

was not significantly different between groups at the end of the<br />

<strong>training</strong> phase (Analysis 1.26) but decreased significantly in the<br />

cardiorespiratory group at the end of the follow-up period (MD -<br />

2.70, 95% CI -4.40 to -1.00) (Analysis 2.18). This trial had, however,<br />

substantial missing values at the end of intervention (29%)<br />

and end of follow up (37%) and there<strong>for</strong>e these findings should<br />

be interpreted with caution. Another trial (Lennon 2008), which<br />

measured participants’ mood using the HADS, reported that the<br />

depression score improved in the intervention group but not in<br />

the control group. We were, however, unable to include these trial<br />

data in out analyses as they were presented in a <strong>for</strong>mat not suitable<br />

<strong>for</strong> RevMan.<br />

Resistance <strong>training</strong> (Comparisons 3 and 4)<br />

One trial (Sims 2009) assessed 88 participants using the Centre <strong>for</strong><br />

Epidemiological Studies <strong>for</strong> Depression scale (CES-D). The mood<br />

in the resistance <strong>training</strong> group was significantly better at the end<br />

of intervention (MD -5.49, 95% CI -9.78 to -1.20) (Analysis 3.12)<br />

and at follow-up (MD -8.92, 95% CI -13.03 to -4.81) (Analysis<br />

4.6).<br />

Mixed <strong>training</strong> (Comparisons 5 and 6)<br />

One trial (Duncan 2003) assessed participants’ mood using both<br />

the emotion domain of the Stroke Impact Scale (SIS) and the<br />

Geriatric Depression Scale. SIS emotion scores were slightly significantly<br />

different between intervention groups at the end of the<br />

18

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