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Official Journal of the American College of Sports Medicine 1469 Board #61 May 30, 3:30 PM - 5:00 PM Paleolithic diet and Exercise suppress hunger during Inter- Meal Interval By different Mechanisms Po-Ju Lin, Katarina Borer. University of Michigan, Ann Arbor, MI. (No relationships reported) Both exercise and higher fat and protein diet have been shown to reduce hunger ratings compared to high carbohydrate diet or sedentary condition. To find out whether this effect has a common mechanism, we examined how Paleolithic (P) versus Western diet (W), and exercise (X) versus sedentary (S) condition affected hunger ratings. Gastric inhibitory polypeptide (GIP) secretion and acetaminophen (APAP) absorption as a marker of gastric emptying (GE) served as a measure of gastrointestinal food transit (GFT). Although GIP has not been implicated in the control of hunger, GIP could affect hunger ratings indirectly by changing GE. PurPOsE: Examine the effect of P and W meal on hunger ratings and plasma GIP and APAP concentrations during X or S condition. METhOds: Twenty-four healthy postmenopausal women participated in 1 of 4 conditions: S or 2 h of X (14 to 16 h) with P or W meal (PS, PX, WS, WX; n=8 each). The P meal contained 30% carbohydrate (CHO), 25% protein (PRO), and 45% FAT while W meal contained 60% CHO, 15% PRO, and 25% FAT. The meal was provided at 10 h. Participants were provided 20ml of liquid acetaminophen (160mg/5ml), 30 minutes after the start of the meal. Plasma GIP and APAP concentrations were measured, and hunger ratings assessed with a visual analog scale, at hourly intervals during 3 h after the start of exercise. Changes in hunger ratings, GIP and APAP concentrations were analyzed with repeated measures mixed model ANOVA. rEsuLTs: Hunger ratings were overall significantly higher after W than after P meal (F=10.3, p
<strong>Thursday</strong>, May 30, 2013 S284 Vol. 45 No. 5 Supplement Moreover, it affects the synthesis of inflammatory proteins, promoting a picture of lowintensity inflammation. Despite this evidence, little attention is given for investigation of strategies that may attenuate this situation. Therefore, the aim of this study was to analyze the effect of caloric restriction on the fat depots and inflammatory proteins in detrained rats. METhOds: Twelve (12) male adult Sprague-Dawley rats were divided into 3 groups (n = 4) after 8 weeks of training on a treadmill. One group (TRAIN) consisted of animals that continued training for 6 more weeks with access to food ad libitum. The other two groups discontinued training and had either access to food ad libitum (DT) or 30% caloric restriction (DTRC) for the next 6 weeks. The animals were euthanized and blood was collected for adipocytokine measurements (leptin, adiponectin, PAI-1 and MCP-1). Retroperitoneal (RET), epididymal (EPI) and subcutaneous (SUB) fat pads were excised and weighed on an analytical scale. Adipocytokines were measured using Lincoplex 200. For statistical analysis, one-way ANOVA was used followed by Scheffe post-hoc test, considering P
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