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Official Journal of the American College of Sports Medicine P for trend = 0.671 for type 2 diabetes, 0.96 (0.75-1.24), 0.87 (0.67-1.13), and 1.07 (0.80-1.43), P for trend = 0.874 for hypertension, and 1.16 (0.92-1.46), 1.35 (1.06- 1.72), and 1.25 (0.96-1.64), P for trend = 0.045 for dyslipidemia, respectively. CONCLusIONs: These results suggest that hand-grip strength is associated with the prevalence of dyslipidemia among Japanese males, although its relation was attenuated after adjusting for body mass index. 1157 Board #102 May 30, 8:00 AM - 9:30 AM dyspnea and all-cause Mortality: 28 year Follow-up study among Twins Katja Waller1 , Jaakko Kaprio2 , Urho M. Kujala1 . 1University of Jyväskylä, Jyväskylä, Finland. 2University of Helsinki, Helsinki, Finland. (No relationships reported) Dyspnea is defined as a respiratory discomfort and breathlessness during exercise and daily activities. In research, dyspnea is often used as pulmonary symptom among medically ill. However, among healthy people, the use of dyspnea during specified activities as a measurement of fitness has not been widely used even though it correlates well with fitness measurements. PurPOsE: The aim is to look how baseline dyspnea, assessed at baseline of a longitudinal study, and changes in it, predicts all-cause mortality during 28 year follow-up. METhOds: The study is based on a prospective Finnish Twin Cohort, which includes all same-sex twin pairs born before 1958. The number of twin pairs with both members alive was 12 069 at the beginning of the follow-up in 1975. These twins answered questionnaires in 1975 and 1981, including questions on physical activity, dyspnea, alcohol use, smoking, and physician diagnosed diseases. Dyspnea is measured by using a five item modified MRC scale. The change in dyspnea between 1975 and 1981 is used as the baseline predictor for mortality. Cox proportional hazard model was used for mortality analysis, and it was started from 1.1.1982 and continued until 31.12.2010. rEsuLTs: Tendency for higher hazard ratios (HR) for mortality was observed among participants who had experienced dyspnea at both (persistent dyspnea) or either of the baseline years. Age, sex and physical activity adjusted analysis showed that participants with persistent dyspnea had higher risk for mortality (HR 1.71, 95 % CI 1.57 - 1.85) compared to participants with no dyspnea. Also, participants with change in dyspnea status showed increased risk, as HR for dyspnea increasers was 1.34 (1.21 - 1.48) and decreasers was 1.23 (1.11 - 1.36) compared to totally symptom free participants. Similar results are shown for a subgroup of healthy subjects as HR with same adjustments was 1.60 (1.40 - 1.83), 1.39 (1.18 - 1.64) and 1.22 (1.05 - 1.41) respectively. dIsCussION: Results show that persistent dyspnea or dyspnea even at one baseline point predicts increased mortality during 28 year follow-up also among healthy subjects. This indicates that easily measured dyspnea score, which correlate well with fitness outcomes, could have a potential as a screening tool for finding people with low levels of fitness and increased mortality risk. 1158 Board #103 May 30, 8:00 AM - 9:30 AM relationship of Contraceptive use, Estrogen replacement Therapy and age on Blood Lipid Profiles in Women Kenneth R. Ecker, FACSM. University of Wisconsin, River Falls, WI. (No relationships reported) PurPOsE: The purpose of this investigation was to assess the relationship of aging, contraceptive use and estrogen replacement therapy on blood lipid profiles in women. METhOds: Six-hundred and thirty-three females ranging in age from 21 to 69 yearsof-age were obtained from a hospital wellness center database. All of the subjects had signed medical release and informed consent prior to when the tests were conducted. The females were comprised of five age groups of ten year increments. A one-way ANOVA was used to analyze the data (p < 0.05), in addition to employing post-hoc comparisons of the least significant difference (p
<strong>Thursday</strong>, May 30, 2013 S218 Vol. 45 No. 5 Supplement 1161 Board #106 May 30, 8:00 AM - 9:30 AM Physical activity and Benign Prostatic hyperplasia / Lower urinary Tract symptoms Kathleen Y. Wolin, FACSM1 , Robert Grubb, III1 , Ratna Pakpahan1 , Lawrence Ragard2 , Jerome Mabie3 , Gerald Andriole1 , Siobhan Sutcliffe1 . 1Washington University School of Medicine St Louis, St Louis, MO. 2Westat, Rockville, MD. 3IMS, Inc, Calverton, MD. (No relationships reported) Benign prostatic hyperplasia (BPH) and its associated lower urinary tract symptoms (LUTS) are extremely common among middle- and older-aged American men. Few studies have investigated physical activity (PA) in relation to BPH/LUTS, with inconclusive results in cross-sectional studies suggesting a protective association. However, as this association may potentially reflect the influence of BPH/LUTS on PA rather than PA on BPH/LUTS, prospective investigations are necessary. PurPOsE: To examine the association of physical activity with incident BPH/LUTS. METhOds: Using observational data from the PLCO, a large well-characterized clinical trial sample, we examined the association of self-reported vigorous PA (current and at age 40) with incident BPH/LUTS. BPH/LUTS was measured at baseline (1993-2001) and follow-up (2006-8) using self-report of physician diagnosis, BPH surgery, finasteride use, nocturia, prostate-specific antigen (PSA) elevation, and large prostate volume. We included 4,771 men in the incident analysis. Poisson regression with robust variance estimation was used to calculate multivariable relative risks (RR) adjusted for age, follow-up time, and number of PSA tests and digital rectal examinations, as appropriate. rEsuLTs: As hypothesized, associations for incident BPH/LUTS differed from previous cross-sectional findings for prevalent BPH/LUTS. PA was not associated with elevated PSA, greater prostate volume, physician diagnosis of BPH, or finasteride use, although it was still inversely associated with nocturia. Men engaging in PA 4+ h/wk were 14% (RR=0.86, 95% CI: 0.76-0.99) less likely to report nocturia ≥2 times/wk and 32% (RR=0.68, 95%CI: 0.51-0.92) less likely to report nocturia ≥3 times/wk than men who were not active. PA at age 40 was not associated with incident BPH. CONCLusIONs: The association of PA with incident BPH/LUTS differs from previous findings for prevalent BPH/LUTS. PA was not associated with incident BPH/ LUTS except when defined as nocturia. Previous studies have suggested that PA may increase sleep quality, which may explain why PA was only associated with nocturia and not other dimensions of BPH/LUTS. 1162 Board #107 May 30, 8:00 AM - 9:30 AM Moderate-to-vigorous Physical activity Thresholds associated with Metabolic syndrome risk Factors Tiago V. Barreira, John M. Schuna, Catrine Tudor-Locke, FACSM, Peter T. Katzmarzyk, FACSM. Pennington Biomedical Research Center, Baton Rouge, LA. (No relationships reported) Current physical activity (PA) guidelines were primarily developed from epidemiological evidence linking self-reported PA levels with chronic disease outcomes. Recently, accelerometer PA data from the National Health and Nutrition Examination Survey (NHANES) has been used to estimate the proportion of US adults meeting PA guidelines. However, PA information collected via self-report and from accelerometers may not be equivalent. PurPOsE: To determine if levels of objectively monitored moderate-to-vigorous PA (MVPA) can adequately discriminate between adults with and without metabolic syndrome (MetS) risk factors. METhOds: 2103 fasted, non-pregnant participants ≥ 20 years of age who had ≥ 4 days of valid accelerometer data (≥ 10 h/dy) and non-missing data for the harmonized MetS risk factors (blood pressure [BP], triglycerides [TG], fasting blood glucose [GLU], high-density lipoprotein [HDL-C], waist circumference [WC]) were included in this analysis of the 03-06 NHANES. MVPA was defined using a threshold of 2020 counts/min. Participants were classified as healthy or unhealthy using the harmonized MetS risk cut-points for each risk factor. MetS was defined as the presence of ≥ 3 risk factors. Receiver operating characteristic curve analysis was used to identify optimal MVPA thresholds to discriminate between healthy and unhealthy adults. rEsuLTs: Discriminatory MVPA thresholds for all MetS risk factors in men were identified with area under the curve (AUC) values ranging from 0.55-0.65 (all p < 0.01). MVPA thresholds were 14-16 min/day for BP, TG, and GLU, 24 min/day for WC, 25 min/day for HDL-C, and 14 min/day for MetS (sensitivity 51%, specificity 72%, AUC 0.63). The optimal MVPA threshold for HDL-C in women was 16 min/day however the AUC (0.55) was non-significant (p = 0.09). MVPA thresholds for all other MetS risk factors were identified, with AUC values ranging from 0.65-0.72 (all p < 0.01). Optimal MVPA thresholds were 10-11 min/day for BP, TG, GLU, and WC. For MetS the MVPA threshold was 10 min/day (sensitivity 71%, specificity 61%, AUC 0.70). CONCLusIONs: Although discriminatory thresholds of MVPA in relation to MetS risk factors were identified, all AUC, sensitivity, and specificity values were fairly low. Daily MVPA thresholds were lower than the current guidelines and different between men and women. MEDICINE & SCIENCE IN SPORTS & EXERCISE ® 1163 Board #108 May 30, 8:00 AM - 9:30 AM Vitality age: Calibration Of a Modifiable risk-related age algorithm, Part of an Incentivised Wellness Program Estelle V. Lambert1 , Kolbe-Alexander Tracy1 , Maroba Josiase2 , Mweete Naglazi1 , Deepak Patel2 , Lori Serradas3 , Rhonda Roscoe3 , Jonathon Dugas3 , Adam Noach2 . 1University of Cape Town, Newlands, South Africa. 2Discovery Health, Johannesburg, South Africa. 3The Vitality Group, Chicago, IL. (No relationships reported) PurPOsE: The primary aim of this study was to compare the Vitality Risk Age (VA), based entirely on modifiable risk factors for cardio-metabolic disease (CMD), against the Framingham Heart Score (FHS) in a cross-sectional sample of persons registered for an employee-sponsored, Vitality wellness program. METhOds: The VA algorithm is comprised of modifiable risk factors including: BMI, smoking, physical activity, alcohol, blood pressure, fasting glucose, cholesterol, depression/anxiety and dietary behavior scores. A combined relative risk was calculated (CRR), to adjust actual age to risk age, based on standardized life expectancy (VA diff %). The sample included de-identified data from all members who completed the health risk assessment (HRA) from Jan-Sept 2011 (Total N=41067, of whom, 4049 reported cardio-metabolic disease, CMD). We calculated the odds ratios for CMD, for each risk factor that contributed to the algorithm, adjusting for gender, and generated receiver operator characteristic curves (ROC) for risk scores predicting CMD, separately for men and women. rEsuLTs: The VA difference for the entire sample was 3.8+4.6 yrs (9% older by risk). The VA diff (yrs and %) were significantly correlated to the FHS scores (r=0.50,r=0.49, respectively, P<0.001). Persons meeting physical activity (PA) guidelines had significantly lower odds ratios for CMD (OR=0.65, 95%CI: 0.60-0.70, P < 0.001). For every 1mmHg increase in systolic blood pressure, there was an 2% increase in the odds of CMD, and for each kg/m2 BMI and cm change in waist circumference, there was a 10% and 4% increase in the odds of CMD, respectively. The c-statistic for the ROC curves for CRR were 0.60 and 0.71, , compared to 0.49 and 0.68 for the FHS, for men and women, respectively. The odds of CMD increased by 1% for each 1% diff in VA diff (%), (P < 0.001). CONCLusIONs: Risk algorithms based on modifiable behaviors, such as physical activity, compare favorably to established risk scores for predicting CMD and provide useful tools to convey behavior change recommendations. 1164 Board #109 May 30, 8:00 AM - 9:30 AM differential sex Effects on Lean Body Mass in response to Concurrent high Intensity Exercise Training Joshua A. Cotter 1 , Tomasz Owerkowicz 2 , Alvin M. Yu 1 , Marinelle L. Camilon 1 , Theresa Hoang 1 , Per A. Tesch 3 , Vincent J. Caiozzo, FACSM 1 , Gregory R. Adams, FACSM 1 . 1 University of California, Irvine, CA. 2 California State University, San Bernardino, CA. 3 Karolinska Institute, Stockholm, Sweden. (Sponsor: Vincent J. Caiozzo, FACSM) (No relationships reported) General health, sporting requirements, and environments, e.g. space flight, that warrant the need for cardiovascular and musculoskeletal maintenance often incorporate both aerobic (AE) and resistance exercise (RE) training. Concurrent training has shown potential interference effects and therefore it is important to examine whether there are sex differences on lean body mass (LBM) responses to concurrent high intensity training. PurPOsE: To determine if concurrent training utilizing high-intensity interval rowing and maximal concentric/eccentric exercise on the Multi-Mode Exercise Device (M-MED), a gravity-independent flywheel exercise device, will exhibit similar changes in LBM regardless of sex. METhOds: Twelve healthy, sedentary males (n=6 , 23.0 ±4.6 yrs, 69.0 ±6.1 kg) and females (n=6, 23.8 ±2.4 yrs, 68.8 ±15.5 kg) completed 5 weeks of concurrent exercise training on the M-MED with alternating days of AE and RE training sessions. AE consisted of high-intensity interval rowing alternating 4 minutes of high intensity (HR at ≥90% VO2max) and 4 minutes of low intensity (HR at 50% VO2max) exercise. RE included maximal intensity horizontal squats, hamstring curls, and heel raises. LBM was assessed using dual energy X-ray absorptiometry (DXA) and whole muscle cross sectional area (CSA) by magnetic resonance imaging (MRI). Training and gender comparisons were made using a two-way ANOVA with repeated measures. rEsuLTs: LBM (3.3%, p
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