Thursday-Abstracts

Thursday, May 30, 2013
S218 Vol. 45 No. 5 Supplement
1161 Board #106 May 30, 8:00 AM - 9:30 AM
Physical activity and Benign Prostatic hyperplasia / Lower
urinary Tract symptoms
Kathleen Y. Wolin, FACSM1 , Robert Grubb, III1 , Ratna
Pakpahan1 , Lawrence Ragard2 , Jerome Mabie3 , Gerald Andriole1 ,
Siobhan Sutcliffe1 . 1Washington University School of Medicine
St Louis, St Louis, MO. 2Westat, Rockville, MD. 3IMS, Inc,
Calverton, MD.
(No relationships reported)
Benign prostatic hyperplasia (BPH) and its associated lower urinary tract symptoms
(LUTS) are extremely common among middle- and older-aged American men. Few
studies have investigated physical activity (PA) in relation to BPH/LUTS, with
inconclusive results in cross-sectional studies suggesting a protective association.
However, as this association may potentially reflect the influence of BPH/LUTS on PA
rather than PA on BPH/LUTS, prospective investigations are necessary.
PurPOsE: To examine the association of physical activity with incident BPH/LUTS.
METhOds: Using observational data from the PLCO, a large well-characterized
clinical trial sample, we examined the association of self-reported vigorous PA (current
and at age 40) with incident BPH/LUTS. BPH/LUTS was measured at baseline
(1993-2001) and follow-up (2006-8) using self-report of physician diagnosis, BPH
surgery, finasteride use, nocturia, prostate-specific antigen (PSA) elevation, and large
prostate volume. We included 4,771 men in the incident analysis. Poisson regression
with robust variance estimation was used to calculate multivariable relative risks
(RR) adjusted for age, follow-up time, and number of PSA tests and digital rectal
examinations, as appropriate.
rEsuLTs: As hypothesized, associations for incident BPH/LUTS differed from
previous cross-sectional findings for prevalent BPH/LUTS. PA was not associated with
elevated PSA, greater prostate volume, physician diagnosis of BPH, or finasteride use,
although it was still inversely associated with nocturia. Men engaging in PA 4+ h/wk
were 14% (RR=0.86, 95% CI: 0.76-0.99) less likely to report nocturia ≥2 times/wk and
32% (RR=0.68, 95%CI: 0.51-0.92) less likely to report nocturia ≥3 times/wk than men
who were not active. PA at age 40 was not associated with incident BPH.
CONCLusIONs: The association of PA with incident BPH/LUTS differs from
previous findings for prevalent BPH/LUTS. PA was not associated with incident BPH/
LUTS except when defined as nocturia. Previous studies have suggested that PA may
increase sleep quality, which may explain why PA was only associated with nocturia
and not other dimensions of BPH/LUTS.
1162 Board #107 May 30, 8:00 AM - 9:30 AM
Moderate-to-vigorous Physical activity Thresholds
associated with Metabolic syndrome risk Factors
Tiago V. Barreira, John M. Schuna, Catrine Tudor-Locke,
FACSM, Peter T. Katzmarzyk, FACSM. Pennington Biomedical
Research Center, Baton Rouge, LA.
(No relationships reported)
Current physical activity (PA) guidelines were primarily developed from
epidemiological evidence linking self-reported PA levels with chronic disease
outcomes. Recently, accelerometer PA data from the National Health and Nutrition
Examination Survey (NHANES) has been used to estimate the proportion of US adults
meeting PA guidelines. However, PA information collected via self-report and from
accelerometers may not be equivalent.
PurPOsE: To determine if levels of objectively monitored moderate-to-vigorous
PA (MVPA) can adequately discriminate between adults with and without metabolic
syndrome (MetS) risk factors.
METhOds: 2103 fasted, non-pregnant participants ≥ 20 years of age who had ≥ 4
days of valid accelerometer data (≥ 10 h/dy) and non-missing data for the harmonized
MetS risk factors (blood pressure [BP], triglycerides [TG], fasting blood glucose
[GLU], high-density lipoprotein [HDL-C], waist circumference [WC]) were included
in this analysis of the 03-06 NHANES. MVPA was defined using a threshold of 2020
counts/min. Participants were classified as healthy or unhealthy using the harmonized
MetS risk cut-points for each risk factor. MetS was defined as the presence of ≥ 3 risk
factors. Receiver operating characteristic curve analysis was used to identify optimal
MVPA thresholds to discriminate between healthy and unhealthy adults.
rEsuLTs: Discriminatory MVPA thresholds for all MetS risk factors in men were
identified with area under the curve (AUC) values ranging from 0.55-0.65 (all p < 0.01).
MVPA thresholds were 14-16 min/day for BP, TG, and GLU, 24 min/day for WC, 25
min/day for HDL-C, and 14 min/day for MetS (sensitivity 51%, specificity 72%, AUC
0.63). The optimal MVPA threshold for HDL-C in women was 16 min/day however the
AUC (0.55) was non-significant (p = 0.09). MVPA thresholds for all other MetS risk
factors were identified, with AUC values ranging from 0.65-0.72 (all p < 0.01). Optimal
MVPA thresholds were 10-11 min/day for BP, TG, GLU, and WC. For MetS the MVPA
threshold was 10 min/day (sensitivity 71%, specificity 61%, AUC 0.70).
CONCLusIONs: Although discriminatory thresholds of MVPA in relation to MetS
risk factors were identified, all AUC, sensitivity, and specificity values were fairly low.
Daily MVPA thresholds were lower than the current guidelines and different between
men and women.
MEDICINE & SCIENCE IN SPORTS & EXERCISE ®
1163 Board #108 May 30, 8:00 AM - 9:30 AM
Vitality age: Calibration Of a Modifiable risk-related age
algorithm, Part of an Incentivised Wellness Program
Estelle V. Lambert1 , Kolbe-Alexander Tracy1 , Maroba Josiase2 ,
Mweete Naglazi1 , Deepak Patel2 , Lori Serradas3 , Rhonda
Roscoe3 , Jonathon Dugas3 , Adam Noach2 . 1University of
Cape Town, Newlands, South Africa. 2Discovery Health,
Johannesburg, South Africa. 3The Vitality Group, Chicago, IL.
(No relationships reported)
PurPOsE: The primary aim of this study was to compare the Vitality Risk Age (VA),
based entirely on modifiable risk factors for cardio-metabolic disease (CMD), against
the Framingham Heart Score (FHS) in a cross-sectional sample of persons registered
for an employee-sponsored, Vitality wellness program.
METhOds: The VA algorithm is comprised of modifiable risk factors including:
BMI, smoking, physical activity, alcohol, blood pressure, fasting glucose, cholesterol,
depression/anxiety and dietary behavior scores. A combined relative risk was
calculated (CRR), to adjust actual age to risk age, based on standardized life
expectancy (VA diff %). The sample included de-identified data from all members who
completed the health risk assessment (HRA) from Jan-Sept 2011 (Total N=41067, of
whom, 4049 reported cardio-metabolic disease, CMD). We calculated the odds ratios
for CMD, for each risk factor that contributed to the algorithm, adjusting for gender,
and generated receiver operator characteristic curves (ROC) for risk scores predicting
CMD, separately for men and women.
rEsuLTs: The VA difference for the entire sample was 3.8+4.6 yrs (9% older
by risk). The VA diff (yrs and %) were significantly correlated to the FHS scores
(r=0.50,r=0.49, respectively, P&lt;0.001). Persons meeting physical activity (PA)
guidelines had significantly lower odds ratios for CMD (OR=0.65, 95%CI: 0.60-0.70,
P &lt; 0.001). For every 1mmHg increase in systolic blood pressure, there was an
2% increase in the odds of CMD, and for each kg/m2 BMI and cm change in waist
circumference, there was a 10% and 4% increase in the odds of CMD, respectively.
The c-statistic for the ROC curves for CRR were 0.60 and 0.71, , compared to 0.49 and
0.68 for the FHS, for men and women, respectively. The odds of CMD increased by
1% for each 1% diff in VA diff (%), (P &lt; 0.001).
CONCLusIONs: Risk algorithms based on modifiable behaviors, such as physical
activity, compare favorably to established risk scores for predicting CMD and provide
useful tools to convey behavior change recommendations.
1164 Board #109 May 30, 8:00 AM - 9:30 AM
differential sex Effects on Lean Body Mass in response to
Concurrent high Intensity Exercise Training
Joshua A. Cotter 1 , Tomasz Owerkowicz 2 , Alvin M. Yu 1 ,
Marinelle L. Camilon 1 , Theresa Hoang 1 , Per A. Tesch 3 , Vincent
J. Caiozzo, FACSM 1 , Gregory R. Adams, FACSM 1 . 1 University
of California, Irvine, CA. 2 California State University, San
Bernardino, CA. 3 Karolinska Institute, Stockholm, Sweden.
(Sponsor: Vincent J. Caiozzo, FACSM)
(No relationships reported)
General health, sporting requirements, and environments, e.g. space flight, that warrant
the need for cardiovascular and musculoskeletal maintenance often incorporate both
aerobic (AE) and resistance exercise (RE) training. Concurrent training has shown
potential interference effects and therefore it is important to examine whether there
are sex differences on lean body mass (LBM) responses to concurrent high intensity
training.
PurPOsE: To determine if concurrent training utilizing high-intensity interval
rowing and maximal concentric/eccentric exercise on the Multi-Mode Exercise
Device (M-MED), a gravity-independent flywheel exercise device, will exhibit similar
changes in LBM regardless of sex.
METhOds: Twelve healthy, sedentary males (n=6 , 23.0 ±4.6 yrs, 69.0 ±6.1 kg) and
females (n=6, 23.8 ±2.4 yrs, 68.8 ±15.5 kg) completed 5 weeks of concurrent exercise
training on the M-MED with alternating days of AE and RE training sessions. AE
consisted of high-intensity interval rowing alternating 4 minutes of high intensity (HR
at ≥90% VO2max) and 4 minutes of low intensity (HR at 50% VO2max) exercise. RE
included maximal intensity horizontal squats, hamstring curls, and heel raises. LBM
was assessed using dual energy X-ray absorptiometry (DXA) and whole muscle cross
sectional area (CSA) by magnetic resonance imaging (MRI). Training and gender
comparisons were made using a two-way ANOVA with repeated measures.
rEsuLTs: LBM (3.3%, p