Official Journal of the American College of Sports Medicine CONCLusION: Caffeine enhanced triathlon performance, but the effect was not as pronounced as seen in previous laboratory trials. Caffeine supplementation taken 45-60 minutes before an Olympic-distance triathlon exerted the greatest effect on performance in the swimming section of the triathlon, as well as on the overall time to complete the triathlon, in the whole subject group. 1110 Board #55 May 30, 8:00 AM - 9:30 AM high but not Low Caffeine Ingestion augments Fluid and Electrolyte Excretion at rest Stavros A. Kavouras, FACSM1 , Costas N. Bardis2 , Petros Grigorakis2 , Georgia Georgiou2 , Anna Gavrieli2 , Mary Yannakoulia2 . 1University of Arkansas, Human Performance Lab, Fayetteville, AR. 2Harokopio University, Athens, Greece. Supported by s.a. Kavouras: Consulting Fee; Gatorade Sports Science Insitute. It is documented that at rest, large doses of caffeine have diuretic effect and in turn may lead to hypohydration. However, the acute effect of smaller caffeine doses on urine excretion is less clear. PurPOsE: The aim of the present investigation was to examine the acute effect of coffee with low (3 mg/kg; L-CAF) or high (6 mg/kg ; H-CAF) caffeine content on fluid and electrolyte urinary excretion in habitual coffee drinkers at rest. METhOds: Twenty-five healthy adult males (age: 28±5 y, body mass index: 28±5, mass: 84.6±7.7 kg, height: 1.79±0.01 m) consumed 200 ml of water (W) or coffee with 3 mg/kg caffeine (L-CAF) on two separate occasions. Nine of the 25 subjects participated in a third trial when consumed coffee high in caffeine (H-CAF). Subjects remained in the laboratory while urine samples were collected every 60 min for three hours. Mean caffeine consumption for L-CAF and H-CAF trials was 254 mg and 552 mg, respectively. The subjects were habitual coffee drinkers (2-3 cups per day) who abstained from foods and drinks containing caffeine or other methylxanthines 24 h before each study. All sessions were performed at 0900 in a counterbalance, crossover manner, at least 5 days apart. rEsuLTs: Cumulative urine volume during the 3h period was significantly elevated only in the higher caffeine trial (W: 292±165 ml, L-CAF: 316±194 ml, and H-CAF: 630±391 ml; P
<strong>Thursday</strong>, May 30, 2013 S206 Vol. 45 No. 5 Supplement methods reached significant levels. 4 correlation tests reached level at 0.01 (M-mode Teichholz and 3D-STE (r=.754, p=0.000), M-mode Teichholz and 3D-AT (r=.-834, p=0.000), 2D Simpson and 3D-STE (r=.610, p=0.007), 3D-STE and 3D-AT (r=.-893, p=0.000). 2 other correlation tests reached level at 0.05 (M-mode Teichholz and 2D Simpson (r=.555, p=0.017), 2D Simpson and 3D-AT (r= -.473, p=0.480). CONCLusION: The differences of correlation levels might be due to several reasons such as dimensional differences, regional vs. global evaluation, resolution quality of images and individual differences of cardiac conditions. 3D Wall Motion Area Tracking can be an alternative for the evaluation of LV-EF. However, further studies with comparison to MRI are needed to evaluate a superiority over one- and twodimensional parameters. 1114 Board #59 May 30, 8:00 AM - 9:30 AM Is The Vasis Classification suitable For Bradycardic Endurance athletes? Frédéric Schnell 1 , David Matelot 1 , Nima Endjah 2 , Gaelle Kervio 3 , Nathalie Thillaye du Boullay 3 , François Carré 1 . 1 LTSI INSERM U1099, Rennes, France. 2 University Hospital of Rennes - Hospital Pontchaillou, Rennes, France. 3 CIC-IT INSERM U804, Rennes, France. (No relationships reported) Currently, VASIS II (cardioinhibitory) syncope during tilt test is objectivated by a Heart Rate (HR)10 sec. However, such classification may be unadapted to bradycardic athletes. Indeed, HR during tilt test can differ a lot between subjects, depending on their resting HR and their individual HR responses to the test. Moreover, tilt test is usually stopped when subjects experience syncope, or intolerable presyncope associated with significant arterial hypotension. In this latter case, HR does not reach its lower value when the test is stopped. PurPOsE. The aim of this study was to assess if the VASIS classification is adapted for bradycardic endurance athletes. METhOd. 39 healthy endurance trained non-smoker men (18-35 years old), with various resting HR, experienced an 80° tilt test for 45 min, without provocative drugs, and with beat-to-beat hemodynamic parameters recording (Task Force Monitor). Tilt test results were blindly and independently classified by 3 investigators used to this test, according to the current VASIS classification, and were then discussed. rEsuLTs. Mean resting HR was 58.4±9.5 bpm, ranging from 40.3 to 76.8. Mean HR in the first 5 min of the tilt test was 75.3±12.1 bpm, ranging from 54.5 to 103.4. Few results raise some questions, as illustrated by the 2 following cases. A bradycardic athlete exhibited a drop of 0.5 bpm/sec (from 64 to 39 bpm in 50 sec), leading to a VASIS II classification. Inversely, a non bradycardic athlete exhibited a drop of 6.6 bpm/sec (from 88 to 55 bpm in 5 sec). However, HR remained >40 bpm as the test was early stopped to avoid complications, so this case was classified VASIS I. CONCLusION. Current criteria proposed to differenciate VASIS I from VASIS II could lead to VASIS II false positive diagnostic in bradycardic athletes, and VASIS II false negative diagnostic in subjects with a high HR during the tilt test. Regarding our results, the question of a new criteria based on the severity and the velocity of the HR drop, and not only on the 40 bpm absolute value may be suggested. This criteria seems particularly relevant for endurance athletes who are both bradycardic and prone to syncope. 1115 Board #60 May 30, 8:00 AM - 9:30 AM Borderline Long QT and QT Interval Prolonging Medications in adolescent athletes Christopher Hoyte 1 , Elizabeth Terhune 2 , Anthony McCanta 2 , Rachel A. Coel 2 . 1 University of Colorado School of Medicine, Aurora, CO. 2 Children’s Hospital Colorado, Aurora, CO. (Sponsor: John Hill, DO, FACSM) (No relationships reported) PurPOsE: To determine whether adolescent athletes taking QT prolonging medications are more likely to display a borderline long or long QT interval. METhOds: Preparticipation exams consisting of physical exam, 12 Lead ECG, and health history including current prescription and over-the-counter medications were performed on 484 adolescents. ECGs with heart rate < 60 or > 100 were interpreted by a pediatric cardiologist using Bazett’s correction formula. Borderline long QT was defined as QTc of 450-500 ms in males and 460-500 ms in females. Long QT was defined as QTc > 500 ms. QT prolonging medications were identified from the Arizona Center for Education and Research on Therapeutics list. Males and females were analyzed separately using Fisher’s exact tests and multiple linear regression analysis. rEsuLTs: Zero athletes exhibited a QTc > 500 ms. Borderline long QT was seen in 2.99% [95% CI: 0.98-6.85%] of females and 8.60% [95% CI: 5.74-12.26%] of males. Median QTc length was 425 ms [range: 373-478] for females and 421msec [range: 358-487] for males. In both the female and male cohorts, there was no difference [p>0.999] in the proportion of subjects with borderline long QTc among subjects taking the QT prolonging medications compared to those subjects not taking the medications (Table 1). After controlling for gender, age and their interaction, there was no difference in QTc interval among subjects taking the medications compared to MEDICINE & SCIENCE IN SPORTS & EXERCISE ® those not taking the medications [mean difference -0.72 ms, 95% CI: -5.92 to 4.35 ms, p=0.8318]. CONCLusION: QT prolonging medications were not significantly associated with the presence of borderline/long QT interval. Further research is needed to evaluate the effects and risks of these drugs during exercise. 1116 Board #61 May 30, 8:00 AM - 9:30 AM Echocardiographic Characteristics of Freshmen NCaa division I Football athletes Dustin P. Joubert 1 , Steven E. Martin 1 , Thomas H. Meade 2 , Freddy Cruz 2 , John P. Erwin 3 , Stephanie White 3 , David Weir 1 , JP Bramhall 1 , Kory Gill 4 , Karl Kapchinski 1 , Stephen F. Crouse, FACSM 1 . 1 Texas A&M University, College Station, TX. 2 Scott & White Clinic, College Station, TX. 3 Scott & White Clinic, Temple, TX. 4 Texas A&M Health Science Center, College Station, TX. (No relationships reported) In the general population, increased left ventricular mass and left atrial size are cardiovascular risk factors. Some data exist describing abnormal cardiac structure in professional American football players after retirement. Less is known about earlier in their careers. PurPOsE: To determine echocardiographic characteristics of freshmen collegiate football athletes relative to reference standards. METhOds: Prior to their competitive season, standard echocardiogram procedures were performed on freshmen, Division I collegiate football athletes (n = 35, age = 18 ± 1 yr, height = 185.9 ± 7.0 cm, weight = 100.0 ± 20.4 kg, body composition = 15.1 ± 8.9 % fat, VO2max = 49.7 ± 7.1 ml·kg-1·min-1). The following cardiac measures were compared to reference ranges for both absolute values and relative to body surface area (BSA, m2) to determine the percentage of athletes exceeding normal: Left ventricle (LV) internal diameter diastolic (LVIDd), left atrial diameter (LAD), LV end diastolic volume (LVEDV), LV end systolic volume (LVESV), interventricular septum (IVS) thickness, LV posterior wall (LVPW) thickness, LV mass (LVM), and ejection fraction (EF). rEsuLTs: Variable Athlete (n = 35) Reference Range % Above Range LVIDd cm 5.4 ± 0.4 4.2-5.9 8.6 cm·m-2 2.4 ± 0.2 2.2-3.1 0 LAD cm 4.2 ± 0.4 3-4 70.6 cm·m-2 1.9 ± 0.2 1.5-2.3 0 LVEDV ml 144.6 ± 25.8 67-155 34.3 ml·m-2 64.3 ± 10.0 35-75 8.6 LVESV ml 56.7 ± 13.1 22-58 48.6 ml·m-2 25.3 ± 5.6 12-30 20.0 IVS cm 1.0 ± 0.1 0.6-1.0 37.1 cm·m-2 0.4 ± 0.1 LVPW cm 1.0 ± 0.1 0.6-1.0 37.1 cm·m-2 0.5 ± 0 LVM g 213.8 ± 42.4 88-224 40.0 g·m-2 96.6 ± 20.2 49-115 11.4 EF % 60.8 ± 5.9 >55 11.4* Values represent mean ± SD. * represents % below reference range CONCLusION: Greater than 30% of the athletes exceeded reference ranges for LAD, LVEDV, LVESV, IVS, LVPW, and LVM. However when expressed relative to BSA, only LVM and LVESV were over range in more than 10% of the athletes. These observations are similar to those found previously in collegiate football players entering the NFL. It appears that cardiac structure in collegiate football athletes is not abnormal when indexed by body size. Supported in part by Huffines Institute of Sports Medicine and Human Performance ACSM May 28 - June 1, 2013 Indianapolis, Indiana
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