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Official Journal of the American College of Sports Medicine 1094 Board #39 May 30, 9:00 AM - 10:30 AM hyaline Cartilage regeneration in Focal Cartilage defect is stimulated by an Innovative acellular Bi-Phasic scaffold Elizaveta Kon 1 , Ken Zaslav 2 , Andrew S. Levy 3 , Jonathan Shani 4 , Vincenzo Condello 5 , Dror Robinson 6 , Nir Altschuler 6 . 1 Rizzoli Orthopaedic Institute, Bologna, Italy. 2 Advanced Orthopedic Centers, Richmond, VA. 3 The Center for Advanced Sports Medicine, Millburn, NJ. 4 Chavat Daat Veterinary Center, Kfar Saba, Israel. 5 Sacre Cuore Don Calabria Hospital, Verona, Italy. 6 Cartiheal Ltd., Kfar Saba, Israel. Supported by E. Kon: Consulting Fee; CartiHeal. PurPOsE: The current study was designed to assess the ability in a caprine model of a bi-phasic cell-free scaffold to support regeneration of bone and cartilage. Results of twelve month pre-clinical study are presented as well as anecdotal results of human implantations. METhOds: The study was conducted on twenty-four Saanen goats. A critical sized focal cartilage defect measuring 6mm diameter by 10mm depth was created in the medial femoral condyle. In sixteen of the goats a bi-phasic implant was inserted into the defect the reset served as empty defect control. The goats were followed for periods of six and twelve months. In vivo the goats were assessed by ultrasonography to evaluate the quality of repair tissue using a categorical score. Following sacrifice, macroscopic evaluation by independent blinded experts (according to Fortier and ICRS), radiographs, micro CT, MRI and blinded histology evaluation (by BioMatech NAMSA) of the condyle were performed. Samples of blood, synovial tissue and synovial fluid were analyzed. rEsuLTs: In the Agili-C (CartiHeal (2009) Ltd.) implanted goats, but not in controls there was evidence of both cartilage and bone regeneration. ICRS macroscopic evaluation at six months after implantation of an Agili-C implant (n=9) were 9.57 ±1.4 vs. 6.33±4.5 in the control group (n=5, and at twelve months after implantation of an Agili-C implant (n=7) 11.29±0.9 vs. 7.33±0.5 in the control group (n=3, p
<strong>Thursday</strong>, May 30, 2013 S202 Vol. 45 No. 5 Supplement possible attenuating effect of non weight-bearing activity on bone strength parameters between genders. 1098 Board #43 May 30, 9:00 AM - 10:30 AM disc degeneration and Limbus Vertebra in Japanese Collegiate Gymnasts Koji Koyama1 , Koichi Nakazato2 , Seok Ki Min2 , Koji Gushiken2 , Yoshiaki Hatakeda2 , Kyoko Seo2 , Kenji Hiranuma2 . 1Tokyo Ariake University of Medical and Health Sciences, Tokyo, Japan. 2Nippon Sport Science University, Tokyo, Japan. (No relationships reported) Magnetic resonance imaging (MRI) studies have shown a higher frequency of radiological abnormalities such as disc degeneration (DD), and limbus vertebra (LV) among gymnasts. These 2 abnormalities seem to coexist at the same spinal level. However, their relationship remains unclear. PurPOsE: To investigate the association between DD and adjacent LV in Japanese collegiate gymnasts. METhOds: The subjects were 104 Japanese collegiate gymnasts (70 men and 33 women aged 19.7 ± 1.0 years, with 11.8 ± 3.6 years of sporting experience), and included Olympic and World Championship medalists. DD and LV were evaluated using T1- and T2-weighted MRI. DD was defined as reduced signal intensity of the intervertebral discs from L1/L2 to L5/S1. The grading system for the assessment of DD was based on the Pfirrmann classification, with grades 3, 4, and 5 indicating degeneration. LV was defined as separate, sclerotic, triangular ossicles adjacent to, but separate from the vertebral endplate. MRI was performed on all the gymnasts, and the images were evaluated by 2 experienced orthopedic surgeons, blinded to the clinical status of the gymnasts. rEsuLTs: The prevalence of DD and LV in the gymnasts was 40.4% (42/104) and 20.2% (21/104), respectively. The incidence of DD was significantly higher in gymnasts with LV than in those without LV, as determined by the chi-square test. By using logistic regression analysis, a significant association of DD with LV (adjusted odds ratio (OR) = 8.54; 95% confidence interval (CI), 2.64-27.57) and with sporting experience (adjusted OR = 0.86; 95% CI, 0.76-0.99) was observed. In addition, we grouped DDs into those occurring in the upper (L1/2, L2/3, and L3/4 discs) and lower (L4/5 and L5/S1 discs) lumbar regions. The presence of upper DD was associated with adjacent LV (adjusted OR = 56.81; 95% CI, 8.87-363.68), and sporting experience (adjusted OR = 0.87; 95% CI, 0.70-1.07). Similarly, the presence of lower DD was associated with adjacent LV(adjusted OR = 8.45; 95% CI, 1.88-38.05), but not sporting experience. CONCLusIONs: Adjacent LV is associated with both, upper and lower DD, and may be an etiological factor for DD in Japanese collegiate gymnasts. 1099 Board #44 May 30, 9:00 AM - 10:30 AM Whole-Body Vibration attenuates Bone resorption Marker responses to acute resistance Exercise in young Men Pragya Sharma-Ghimire, Zhaojing Chen, Xin Ye, Tory Keeter, Kaelin Young, Eonho Kim, Christopher Poole, Daeyeol Kim, Michael Bemben, FACSM, Debra Bemben, FACSM. University of Oklahoma, Norman, OK. (No relationships reported) Bone turnover marker (BTM) responses to acute exercise is an area of growing interest, however, few studies have examined BTM responses to combined resistance exercise and whole-body vibration (WBV). PurPOsE: To investigate acute BTM responses to high-intensity resistance exercise with and without whole-body vibration in young men. METhOds: 10 men (23.1± 1.9 years) participated in this randomized crossover study. 1-RM testing was performed for 4 lower body and 2 upper body isotonic resistance exercises. Subjects performed 2 protocols in random order separated by 2-week wash out periods: 1) resistance exercise only (RE) and 2) WBV + RE. For WBV + RE, subjects stood barefoot with knees slightly flexed on the vibration platform for 5, 1-minute bouts at 20 Hz and 1.25 mm (amplitude) separated by 1-minute rest intervals, followed by resistance exercise. For RE, subjects completed 3 sets of 10 reps at 80% 1-RM. Fasting morning blood draws were taken before (Pre), immediately post (IP) exercise, and 30 minutes (30P) after exercise. WBV + RE also included a blood draw between the WBV exposure and resistance exercise (VibP). Blood samples were analyzed for hematocrit, bone-specific alkaline phosphatase (Bone ALP, U/L) and tartrate-resistant acid phosphatase 5b (TRAP5b, U/L). rEsuLTs: There was a significant time effect for Bone ALP (p
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