Thursday-Abstracts

Official Journal of the American College of Sports Medicine
exercise training at 60 minutes a day; 3 days per week. The intervention consisted of
progressive cardiovascular and whole-body strength training. Participants were then
reassessed following the intervention.
rEsuLTs: There were significant increases in pre to post VO2peak[[Unsupported
Character - Codename ­]] (19.1 to 23.4 mL·kg-1·min-1; p=.006), chest press (50.3
to 62.0 lbs.; p=.016), and leg press (143.2 to 190.8 lbs.; p=.000). CRF significantly
decreased (4.37 to 2.97; p=.006) from pre to post exercise. A negative correlation was
observed between CRF and leg press (p= .07, r= -.430) and VO2peak (p = .36, r=
-.23), however, a positive correlation was seen with chest press (p=.55, r= .15). This
suggests that lower body exercises may have a greater effect on the reduction of CRF
than cardiovascular fitness.
CONCLusIONs: Cancer treatment-related side-effects lengthen the recovery process
post treatment for cancer survivors. The results of this study demonstrate that exercise
interventions increase strength and cardiovascular fitness while decreasing CRF.
Cardiovascular fitness and lower body strength correlate with a reduction in CRF.
Lower body strength was shown to have a higher correlation with decreased CRF than
upper body strength or cardiovascular fitness. Therefore, rehabilitation programs for
cancer survivors with a goal of reducing CRF should incorporate lower body strength
training.
997 Board #7 May 30, 8:00 AM - 10:00 AM
Moderate Intensity acute aerobic Exercise Effect on Natural
Killer Cell Counts in Breast Cancer survivors
Claudio Battaglini, Elizabeth Evans, Robert McMurray, FACSM,
Scott Randell, Hyman Muss, A.C. Hackney, FACSM. University
of North Carolina at Chapel Hill, Chapel Hill, NC.
(No relationships reported)
Current research examining the effect of acute aerobic exercise on immune responses
in cancer survivors is limited.
PurPOsE: To examine the effect of one acute bout of aerobic exercise on natural
killer (NK) cell counts in breast cancer survivors (BCS) and healthy controls (C).
METhOds: Participants included 9 women who had completed major treatments
for Stage I-III invasive breast cancer within 3-6 months of enrollment and 9 sedentary
women without a history of cancer. Subjects completed a 30-minute bout of exercise
on the cycle ergometer at 60% of VO2peak. Blood samples were taken pre-exercise,
immediately post-exercise, 2 hours post-exercise, and 24 hours post-exercise.
Complete blood counts were obtained at each time point. Proportions of lymphocytes
that carry the NK cell phenotype (CD3-CD16+CD56+) were obtained via flow
cytometric analysis. NK cell counts were compared between groups across time points
using a 2x4 mixed model ANOVA.
rEsuLTs: NK cell counts rose significantly from pre-exercise to immediately postexercise
in both the BCS and C groups (70.3 ± 37.9 cells/μL to 214.3 ± 132.0 cells/
μL, p = 0.003 and 108.9 ± 51.7 cells/μL to 357.5 ± 171.1 cells/μL, p = 0.001). At 2
hours post-exercise, NK cell counts tended to remain elevated in the BCS group (92.1
± 62.4 cells/μL) relative to pre-exercise (p = 0.096). At 24 hours post-exercise, NK cell
counts also tended to be elevated in the BCS group (106.3 ± 66.8 cells/μL, p = 0.052)
and in the C group (142.3 ± 74.6, p = 0.097) relative to pre-exercise. When comparing
between groups, NK cell counts were somewhat lower in the BCS group compared to
the C group pre-exercise (p = 0.09) and immediately post-exercise (p = 0.064).
CONCLusIONs: Although some lower in NK cell counts, recent BCS seem to
exhibit a normal NK cell response to acute moderate intensity aerobic exercise as
compared with similar women without a history of cancer.
Supported by UNC Lineberger Comprehensive Cancer Center and Petro Kulynych
Foundation
998 Board #8 May 30, 8:00 AM - 10:00 AM
The utility of Exercise or Pharmacological stress in
Identifying Cardiac damage in Breast Cancer survivors
Amy A. Kirkham, Kristin L. Campbell. University of British
Columbia, Vancouver, BC, Canada.
(No relationships reported)
The addition of myocardial stress to cardiac imaging techniques may increase
sensitivity in identifying breast cancer treatment (BCT) related cardiac damage.
PurPOsE: To systematically review whether cardiac imaging with exercise or
pharmacologic stress (SI) can better identify cardiac damage in breast cancer survivors
(BCS) than imaging at rest (RI).
METhOds: Medline, Embase and CINAHL were searched using (breast cancer)
AND (keywords related to cardiac imaging) AND (keywords related to cardiotoxic
BCT or related cardiac issues). All experimental or observational studies including ≥2
cardiac imaging techniques/parameters and BCS only, were searched to identify studies
that used both SI and RI. Studies were also excluded if they did not report the SI data
for ≥10 BCS or included cancer treatments no longer used for BCS. Ten studies were
included in the review and relevant data extracted. The results of SI were compared to
those of RI, and each study was labeled as “no benefit,” “some benefit,” or “benefit,”
based on whether the SI identified cardiac damage that was not detected by the RI.
rEsuLTs: Overall, 3 studies showed “no benefit”, 2 showed “some benefit” and
5 showed a “benefit” of SI over RI. The use of exercise or pharmacologicals to
Vol. 45 No. 5 Supplement S179
induce myocardial stress was evenly split amongst the studies showing “benefit”
or “some benefit” (1 study used both). Six of the 7 studies showing at least some
benefit were long-term follow-up (LTFU) studies of 34 months to 18 years posttreatment
(chemotherapy and/or radiation), and the other followed patients through
chemotherapy up to 18 months later. All of the studies with LTFU of radiation
treatment (n=5) (some included chemotherapy as well), showed at least some benefit of
SI over RI, with the exception of one study reporting no damage with SI or RI. These
studies all used myocardial perfusion imaging (MPI) techniques. Other techniques
showing the benefit of SI were echocardiography (n=2, 1 during and 1 LTFU to
chemotherapy) and ECG (n=2, both LTFU to radiation and/or chemotherapy).
CONCLusIONs: MPI with exercise or pharmacological stress appears to be
beneficial for detection of cardiac damage in LTFU to radiation treatment for breast
cancer. Both ECG and echocardiography with stress merit further research to
determine their utility in identifying BCT-induced cardiac damage.
C-17 Thematic Poster - Perceptual and Cognitive
Response to Heat Exposure
May 30, 2013, 8:00 AM - 10:00 AM
Room: 207
999 Chair: Alan Utter, FACSM. Appalachian State University,
Boone, NC.
(No relationships reported)
1000 Board #1 May 30, 8:00 AM - 10:00 AM
skin Temperature and heart rate Estimate Physiological
strain during Exercise In The heat
John Cuddy1 , Mark Buller2 , Walter Hailes1 , Brent Ruby,
FACSM1 . 1The University of Montana, Missoula, MT. 2US Army
Research Institute of Environmental Medicine, Natick, MA.
(No relationships reported)
Skin temperature and heart rate have previously been used to predict physiological
strain during exercise in the heat.
PurPOsE: To evaluate the previously developed physiological strain index model
using heart rate and skin temperature to provide further insight into the detection and
estimation of thermal and physiological heat strain indices. A secondary aim was to
characterize individuals who excel in their performance in the heat compared to those
who perform poorly.
METhOds: 56 male participants (22 ± 3 yrs, 181 ± 9 cm, 81 ± 12 kg, 4.2 ± 0.6
L•min-1) completed the study. Participants completed 2 trials using a randomized,
counterbalanced cross-over design in a temperature and humidity controlled
environmental chamber in ambient conditions of 43.3°C and 40% relative humidity,
and 15.5°C and 40% humidity. Core and skin temperature, along with heart rate and
physiological strain index, were continually monitored during exercise. Additionally,
participants completed a United States Marine Corps (USMC) physical fitness test.
rEsuLTs: Based on the highest PSI achieved during the 90 minute walk, 23
participants were classified in the “At Risk” group while 33 participants were classified
in the “Not at Risk” group. The logistic regression model exhibited 4 false positives and
1 false negative at the 40% decision boundary. The “Not at Risk” group had higher body
weight (84 ± 13 vs. 77 ± 10 kg, respectively) and fat free mass (71 ± 9 vs. 64 ± 8 kg,
respectively) compared to the “At Risk” group, p