Thursday-Abstracts
Thursday-Abstracts
Thursday-Abstracts
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Official Journal of the American College of Sports Medicine<br />
can reduce bronchoconstriction and airway inflammation on their own. The variable<br />
responses obtained in this study suggest that for subjects not reaping the full benefits<br />
from either supplement alone, a combination of fish oil and vitamin C may be more<br />
effective.<br />
1267 Board #213 May 30, 8:00 AM - 9:30 AM<br />
decrements In Pulmonary diffusing Capacity With duration<br />
Of disease In Type-1 diabetes<br />
Michelle J. Lee1 , J Christopher Baldi, FACSM2 , J Richard,<br />
Coast, FACSM1 . 1Northern Arizona University, Flagstaff, AZ.<br />
2University of Otago, Dunedin, New Zealand.<br />
(No relationships reported)<br />
Diabetes is known to affect peripheral tissues by damaging capillaries and basement<br />
membranes, however, its effects on the lung are less known. Lung diffusing capacity<br />
(DLCO) is influenced by alveolar-capillary membrane conductance (DM) and<br />
pulmonary capillary blood volume (VC), both of which have shown impairments in<br />
adults with type-1 diabetes (T1D).<br />
PurPOsE: We sought to determine the effect of T1D, age, and diabetes duration on<br />
DLCO, DM, VC, and cardiac output (Q).<br />
METhOd: We recruited 48 subjects, 24 people with T1D (ages 10.7 – 52.8 years old)<br />
and 24 non-diabetic controls matched for age, gender, and fitness level and measured<br />
DLCO, DM, VC, and Q at rest and three exercise workloads (40% VO2max, 70%<br />
VO2max, and 90% VO2max).<br />
rEsuLTs: When stratified into two groups based on age (young < 20.6 years old),<br />
there were no significant differences in DLCO, DM, VC, or Q (all of which were<br />
normalized to body surface area [BSA]) in the young group, or in the old group. When<br />
stratified into two groups based on diabetes duration (short duration range 0.33 – 8.9<br />
years, long duration range 9.6 – 28 years), the T1D in the long duration group had<br />
significantly lower DLCO/BSA and DM/BSA compared to the matched controls (16.5<br />
± 0.6 and 19.0 ± 0.6 mL/min/mmHg/BSA, p= 0.014 and 22.5 ± 0.9 and 25.6 ± 0.9 mL/<br />
min/mmHg/BSA, p= 0.033, respectively) with no differences in VC/BSA and Q/BSA.<br />
There were no differences in any of the variables in the short duration group.<br />
CONCLusION: While we initially hypothesized that age would be a factor in the<br />
decrements in lung function, this study has shown that independent of age, duration<br />
of diabetes is a factor more associated with decrements in diffusing capacity and its<br />
components. Supported by NIH Grant R15 HL097335-01A1.<br />
1268 Board #214 May 30, 8:00 AM - 9:30 AM<br />
Carbon Monoxide reduces O 2 Extraction but not Peripheral<br />
Tissue diffusing Capacity at VO 2 max<br />
George H. Crocker, James H. Jones. University of California,<br />
Davis, CA.<br />
(No relationships reported)<br />
PurPOsE: We hypothesized that breathing hypoxic gas and/or carbon monoxide<br />
(CO) would similarly affect peripheral tissue (skeletal muscle) O2 extraction (EO2,<br />
fraction of O2 delivered that is consumed) and diffusing capacity for O2 (DTO2),<br />
despite altering aerobic capacity by different mechanisms – decreased blood O2<br />
saturation (hypoxia) vs. decreased circulatory capacitance (CO).<br />
METhOds: We ran six goats on a treadmill at speeds eliciting maximal aerobic<br />
capacity while breathing inspired O2 fraction (FIO2) of 0.21 or 0.12 and maintaining<br />
carboxyhemoglobin fraction (FHbCO) of 0.02 or 0.30. We measured O2 consumption<br />
(VO2) and sampled arterial and mixed-venous blood to calculate cardiac output (Q) via<br />
Fick Principle and total cardiopulmonary O2 delivery (TO2, product of Q and arterial<br />
[O2]). We calculated for each gas EO2 as VO2/TO2 and DTO2 as VO2/mixed-venous<br />
O2 tension (PvO2).<br />
rEsuLTs: Compared to room air (EO2 0.90 ± 0.03), EO2 decreased with FHbCO<br />
0.30 when breathing either FIO2 0.21 or 0.12 (EO2 0.79 ± 0.04 and 0.81 ± 0.03) and<br />
increased with hypoxia alone (EO2 0.92 ± 0.02). The VO2 and PvO2 were highly<br />
correlated and the slopes of the regressions were significant for five of six goats<br />
(0.951 < R2 < 0.994, P < 0.001 for each). The DTO2 did not differ between the four<br />
FIO2/FHbCO combinations (P = 0.867). We analyzed data from previous studies that<br />
calculated DTO2 as the slope of VO2 vs. PvO2 for various inspired gases. Compared<br />
to the means of individual points, DTO2 estimates based on slope are biased high when<br />
the VO2 vs. PvO2 intercept is negative and low when the VO2 vs. PvO2 intercept is<br />
positive.<br />
CONCLusIONs: The EO2 differed for hypoxia and elevated FHbCO, indicating<br />
goats had to deliver more O2 with elevated FHbCO than with hypoxia to reach<br />
similar VO2, suggesting CO impairs (and hypoxia improves) the ability to extract<br />
and consume O2 compared to normoxia. However, DTO2 was unchanged by FIO2<br />
or FHbCO. Oxyhemoglobin affinity effects on diffusion pressure head explain the<br />
EO2 differences observed. Because non-zero intercepts of VO2 vs. PvO2 bias DTO2<br />
estimates, future studies should calculate DTO2 both as the average of individual gas<br />
mixtures as well as the slope of VO2 vs. PvO2 for all gases. Supported by the U.S.<br />
Army Medical Research and Materiel Command (Contract No. W81XWH-11-D-0011)<br />
through L-3/Jaycor.<br />
Vol. 45 No. 5 Supplement S245<br />
1269 Board #215 May 30, 8:00 AM - 9:30 AM<br />
Breathing Pattern and strategy during Exercise In young<br />
swimmers and Non-swim Trained Children<br />
Joel M. Stager, FACSM, Kosuke Kojima, Masataka Ishimatsu,<br />
Daniel P. Wilhite, Brian V. Wright. Indiana University,<br />
Bloomington, IN.<br />
(No relationships reported)<br />
Swim training has been suggested to promote proportionate lung growth though the<br />
training effects on pulmonary function remain controversial (Courteix et al., 1997;<br />
Silvestri et al., 2012). Specifically, breathing patterns and strategies during incremental<br />
exercise in young swimmers as compared with non-swim trained children have not<br />
been documented.<br />
PurPOsE: To characterize the breathing patterns and strategies of young swimmers<br />
during incremental exercise to volitional exhaustion and compare those measures to<br />
age- and size-matched non-swim trained children.<br />
METhOds: Twenty four healthy non-asthmatic, young, competitive swimmers (12<br />
girls and 12 boys; 10.5 yrs, 144.5 cm, 38.0 kg) and 11 non-swim trained children (4<br />
girls and 7 boys; 10.2 yrs, 141.1 cm, 33.3 kg) performed resting pulmonary function<br />
and incremental exercise tests to volitional exhaustion (VO 2peak ) on a cycle ergometer.<br />
Pulmonary function was collected during a set of maximal inspiratory and expiratory<br />
maneuvers for the determination of the maximal flow-volume loop. Metabolic<br />
and ventilatory data were recorded at each minute during the VO 2peak test. Exercise<br />
inspiratory and expiratory tidal volume (V Tinsp and V Texp ) and peak flow (PF Tinsp and<br />
PF Texp ) were measured during the last 30 sec of each minute, and inspiratory and<br />
expiratory reserve volumes (IRV and ERV) were determined using inspiratory capacity<br />
maneuvers.<br />
rEsuLTs: At rest, swimmers showed significantly greater forced vital capacity (2.37<br />
± 0.40 vs. 1.84 ± 0.56 L) and maximal mid expiratory flow (2.90 ± 0.71 vs. 2.34 ± 0.65<br />
Lsec-1). The groups were similar in relative VO2 (47.3 ± 7.95 vs. 43.7 ± 9.09 mlmin-<br />
1kg-1 at peak), breathing frequency, and IRV at 60, 70, 80, 90 and 100% of VO2peak.<br />
Greater minute ventilation (70.6 ± 19.3 vs. 53.6 ± 11.2 L at VO2peak), tidal volume<br />
(1.29 ± 0.32 vs. 0.99 ± 0.19 L at VO2peak), ERV, VTinsp, VTexp, PFTinsp, and<br />
PFTexp were observed in swimmers throughout the exercise bout (p < 0.05).<br />
CONCLusION: With no difference in breathing frequency, the higher tidal flow in<br />
young swimmers permitted a higher tidal volume, thus allowing for greater minute<br />
ventilation during incremental exercise. Young swimmers seem to exploit a higher<br />
available expiratory airflow by breathing at higher lung volumes possibly as a means<br />
of avoiding mechanical constraints to ventilation.<br />
1270 Board #216 May 30, 8:00 AM - 9:30 AM<br />
Effects Of heliox On respiratory Mechanics and Cycling<br />
Performance In Endurance-trained Men and Women<br />
Sabrina S. Wilkie, Paolo B. Dominelli, Benjamin C. Sporer,<br />
Michael S. Koehle, A. William Sheel. University of British<br />
Columbia, Vancouver, BC, Canada.<br />
(No relationships reported)<br />
Mechanical ventilatory constraints develop in some endurance-trained (ET) men<br />
during strenuous exercise. Both ET and untrained women have been shown to develop<br />
expiratory flow limitation (EFL) during maximal and sub-maximal exercise. Women’s<br />
increased susceptibility to EFL can be attributed to structural and functional sex-based<br />
differences with respect to the pulmonary system. Consequently women’s endurance<br />
performance may be limited to a larger extent than men’s through increases in the work<br />
of breathing (WOB) and higher sensations of leg and breathing discomfort.<br />
PurPOsE: To determine the effects of partially unloading the respiratory system<br />
using a heliox (He-O2; 79% He, 21% O2) inspirate on EFL, the WOB, operational<br />
lung volumes, sensory responses (leg and breathing discomfort) and cycling<br />
performance between men and women.<br />
METhOds: Competitive cyclists (n = 11 men; n = 11 women) completed two 5-km<br />
time trials (TT), breathing either room air (RA) or He-O2. The maximum expiratory<br />
flow-volume (MEFV) curve method was used to determine EFL. The WOB was<br />
measured with an esophageal balloon catheter.<br />
rEsuLTs: During both the RA and He-O2 TTs EFL developed in men (RA: n =<br />
36%; He-O2: n = 45%) and women (RA: n = 60%; He-O2: n = 40%). The magnitude<br />
of EFL was variable throughout both TTs for all subjects due to alterations in endexpired<br />
lung volume and expiratory flow rates. At 5-km women’s minute ventilation<br />
was significantly lower than men’s (RA-women: 94.417.8; men: 134.412.7; p