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Official Journal of the American College of Sports Medicine ANOVA, controlling for age, weight, calcium and compliance. rEsuLTs: Six young adults (4F, 2M, age 23 ± 2.4 years) volunteered to participate. All bone, muscle and fat parameters improved over the training period, except tibial density at the 4% site, with greater improvements in the barefoot limb; however, no effect reached statistical significance. A 4.5% increase in lower extremity lean mass (p=0.01) and 10.1% decrease in fat mass (p=0.002) was observed in the barefoot limb only. CONCLusIONs: Power was low in this pilot trial, thus positive footwear-specific skeletal responses to the osteogenic training program did not reach statistical significance. By contrast, greater increases in lean mass and decreases in fat mass were detected in the lower extremity wearing the barefoot shoe during training. The novel within-subject design was an effective control of individual variation with no adverse effects. 1069 Board #14 May 30, 9:00 AM - 10:30 AM Estrogen receptor-alpha Genotype affects Exercise-related Bone density In Japanese young Women Hiroyo Kondo 1 , Hidemi Fujino 2 , Shinichiro Murakami 3 , Naoto Fujita 2 , Fumiko Nagatomo 4 , Akihiko Ishihara 4 . 1 Nagoya Women’s University, Nagoya, Aichi, Japan. 2 Kobe University, Kobe, Japan. 3 Himeji Dokkyo University, Himeji, Japan. 4 Kyoto University, Kyoto, Japan. (No relationships reported) Osteoporosis is a systemic skeletal disease characterized by low density and fragile in bone. Estrogen is essential for mechanotransduction, and estrogen receptor alpfa (ER1) is one of genetic candidates for a prime regulator of bone metabolism. PurPOsE: The purpose of this study was to assess the interactive effects of habitual exercise, calcium intake and ER1 gene polymorphisms on bone density in young women. METhOds: 160 Japanese healthy young women (20-23 years old) were recruited in this study. Habitual exercise and nutrient intake were assessed using a questionnaire. Bone mass was measured by quantitative ultrasound measurement. The polymorphisms of ER1 at intron I (rs2234693 and rs9340799) was genotyped using the TaqMan probe-based SNP method. rEsuLTs: The subjects with habitual exercise and high milk intake were significantly higher bone density than those with non-habitual exercise and low milk intake. The subjects with ER1 genotype CC of rs2234693 had lower bone density than those with ER1 genotype TT in non-habitual exercise group. Interestingly, the subjects with ER1 allele C, or both CT and AG of rs9340799 in the habitual exercise group had significantly higher bone density than those in the non-habitual exercise group although the subjects without ER1 allele C or both CT and AG were no significant bone density between the habitual exercise group and the non-habitual exercise group. CONCLusIONs: These results suggest that habitual exercise is more important for bone mass metabolism in young women carrying C allele and/or AG genotype in ER1 polymorphisms. Supported by Grants-in-Aid for Science Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology. 1070 Board #15 May 30, 9:00 AM - 10:30 AM relationship Between The sarcopenic Index, Body Composition and Muscular strength in Breast Cancer survivors Takudzwa A. Madzima1 , Emily Simonavice2 , Pei-Yang Liu3 , Jasminka Z Ilich1 , Jeong-Su Kim1 , Michael J. Ormsbee1 , Carla M. Prado1 , Lynn B. Panton, FACSM1 . 1Florida State University, Tallahassee, FL. 2Georgia College & State University, Milledgeville, GA. 3The University of Akron, Akron, OH. (No relationships reported) Breast cancer survivors (BCS) encounter side effects from cancer treatments that negatively affect body composition, particularly muscle loss which may lead to sarcopenia. Additionally, this may result in osteosarcopenia, the concurrent loss of bone and muscle mass. Appendicular skeletal muscle adjusted by squared height (ASM index; kg/m2) has been used to define sarcopenia. PurPOsE: To evaluate the relationships between the ASM index, strength, and total and regional bone mineral density (BMD) in BCS. METhOds: Forty-four (60±9 yrs) BCS participated. Body composition and BMD of the total body, lumbar spine (L1-L4), hip (femur), radius, ulna and total forearm were measured by DXA. Upper and lower body strength was measured via one-repetition maximum (1RM) on chest press and leg extension machines. Handgrip (HG) strength was assessed using a HG dynamometer. The BCS were separated into two groups comprised of those that fell above (>) and below ( 6.39 Vol. 45 No. 5 Supplement S195 kg/m2 (total body: >1.182±0.135 g/cm²; : 0.518±0.059 g/cm²; : 0.474±0.064 g/cm²; : 0.499±0.059 g/cm²;
<strong>Thursday</strong>, May 30, 2013 S196 Vol. 45 No. 5 Supplement 1073 Board #18 May 30, 9:00 AM - 10:30 AM Excess Body Fat has Negative Impacts on hip strength in Competitive athletes with Menstrual dysfunction Sheng-An Lo 1 , Kuei-Hui Chan 2 , Yi-Ting Lin 3 , Chien-Wen Ho 3 . 1 Graduate Institute of Coaching Science, Taoyuan, Taiwan. 2 Graduate Institute of Coaching Science, Taoyaun, Taiwan. 3 Laboratory of exercise Biochemistry, Taipei, Taiwan. (No relationships reported) Hip strength (HS) analysis is measures of proximal femur strength in axial compression or bending. Fat mass (FM) and lean body mass (LBM) are positively related to bone mass in young athletes with eumenorrhea. However, the relation in ones with menstrual dysfunction is less known. PurPOsE: To determine effects of body composition (BC) on bone health in athletes with menstrual dysfunction. METhOds: Thirty-one athletes with MD (20.1±1.9 yrs) were selected by a questionnaire from 134 collegiate female athletes. They did not take any menstrual regulators during the past a year. Blood samples were collected during day-3 to day-5 of menses to assess sex hormones of luteinizing hormone, follicle-stimulating hormone, and estradiol. BC and bone mineral density (BMD) of hip, femoral neck, and Ward’s triangle were assessed by dual-energy X-ray absorptiometry. BC variables included LBM, FM in whole body (FMWB), wasit (FMW), and hip (FMh) and body fat percentage in the same parts (BF%WB, BF%w, and BF%h). HS variables of crosssectional area (CSA), cross-sectional moment of inertia (CSMI), hip axis length, and femur strength index (FSI) were assessed by the HS analysis program. All subjects were divided into normal (Nor) and high body fat (H) groups by BF% ≤25%. Pearson’s correlations and independent t-tests were used to analyze all continuous variables. rEsuLTs: Between the Nor and the H groups, there were significant differences in BMI, BF%WB, BF%W, BF%h, and FMWB (12.5±1.7 vs. 20.1±5.8 kg, p
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