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Official Journal of the American College of Sports Medicine models to estimate internal knee loads during running, and have shown that increasing step rate (i.e. shortening step length) can reduce patellofemoral (PF) loading. However, many clinics do not have sophisticated modeling technology available, and would benefit from a simpler way to assess PF loads. PurPOsE: To determine what kinematic and kinetic variables predict PF loads when running. METhOds: 30 healthy runners (35±15 yrs, 69.6±10.8 kg, 1.76±0.10 m) had whole body kinematics and ground reaction forces measured while running on an instrumented treadmill. Each ran at his/her preferred speed (2.79±0.48 m/s) at three step rates: 90, 100, and 110% of preferred. Running mechanics were analyzed using a musculoskeletal model that included a 1-degree of freedom PF joint. Inverse kinematics and dynamics were used to compute joint angles and moments. Numerical optimization was then used to estimate muscle, patellar tendon and joint reaction forces. Peak PF force was calculated over five strides from each condition. A forward step-wise fitted repeated measures-ANOVA model was created with PF force per unit body weight as the response variable. rEsuLTs: PF force was significantly increased (+15%) at the 90% step rate, and decreased (-14%) at the 110% condition (p
<strong>Thursday</strong>, May 30, 2013 S336 Vol. 45 No. 5 Supplement compared to 85% VO2max (2.54 ± 0.73 vs. 2.01 ± 0.45 ml min-1 mmHg-1, resp). CVC increased (p 0.05) for both conditions. The amount of RMF was related (r=0.61; p 0.05) between the ΔFEV1% pre-post exercise and %EFL at VO2max. However, in children MEDICINE & SCIENCE IN SPORTS & EXERCISE ® that demonstrated clinically relevant EIB (i.e.,>10% decrease in FEV1; n=22), there was a significant relationship (r = 0.66, p < 0.05) between EIB and EFL. In study two (n=16), with training, children improved pre-post exercise ΔFEV1% (pre:-7.60 ± 2.10%, post:-1.10 ± 1.80%, p < 0.05). There was an association between ΔFEV1% and Δ%EFL from pre- to post-training (r = 0.77, p < 0.05) in the TRG only. CONCLusION: These data suggest that pre-adolescent children who exhibit clinically relevant EIB also demonstrate the most severe expiratory flow limitation during exercise. With exercise training, reductions in EIB are associated with reduced EFL. These findings may be important in prevention and treatment of exercise intolerance in pre-adolescent children. 1746 Board #4 May 30, 3:15 PM - 5:15 PM Peak Oxygen uptake differs Between Obese Women With Vs. Without dyspnea On Exertion J. Todd Bassett, Vipa Bernhardt, Santiago Lorenzo, Raksa B. Moran, Sarah F. Haller, Jessica M. Pineda, Tony G. Babb, FACSM. Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas and University of Texas Southwestern Medical Center, Dallas, TX. (No relationships reported) PurPOsE: During constant load exercise, some otherwise healthy obese women experience dyspnea on exertion (+DOE), while others do not (-DOE). In previous studies, we observed exercise capacity to be similar in -DOE and +DOE. We questioned whether this would remain true if we sampled a larger number of obese women. METhOds: To investigate, we recruited 80 otherwise healthy obese women who were divided into groups based on their Ratings of Perceived Breathlessness (RPB, Borg 0-10 scale) at the end of 6 minutes of constant load cycling (60W), as in prior studies. 24 women were designated as -DOE (RPB≤2, 32±8 yr, 37±4 BMI, mean±SD) and 34 women were classified as +DOE (RPB≥4, 34±7 yr, 36±5 BMI). 22 women with RPB=3 were excluded to better delineate the groups. Peak oxygen uptake was determined during maximal incremental cycle ergometry. Data were analyzed between groups by independent t-test. The relationship between variables was determined by linear regression analysis. rEsuLTs: While peak oxygen uptake was within normal limits in both groups, exercise capacity (as % of predicted) was greater (p
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