Thursday-Abstracts
Thursday-Abstracts
Thursday-Abstracts
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Official Journal of the American College of Sports Medicine<br />
1350 Board #7 May 30, 1:00 PM - 3:00 PM<br />
aMPK Play a role In The substrate Energy selection<br />
during Post Exercise recovery<br />
Andreas Mæchel Fritzen, 1987, Mette Landau Brabæk<br />
Christiansen, Jacob Jeppesen, Bente Kiens. Copenhagen<br />
University, Copenhagen, Denmark.<br />
(No relationships reported)<br />
Several studies have shown a substantial fractional fatty acid (FA) oxidation during<br />
the post exercise period. It appears that after exercise muscle glycogen resynthesis has<br />
such a high metabolic priority that a higher utilization of lipids to cover the energy<br />
expenditure in the muscle cell is observed. Interestingly, the mechanisms responsible<br />
for the selection of energy substrate in muscle post-exercise are virtually unknown,<br />
and the mechanism(s) regulating post exercise increased FA oxidation has not been<br />
fully explained. AMP-activated kinase (AMPK) has been found to be involved in FA<br />
oxidation at rest and could potentially play a role in fuel selection post exercise.<br />
PurPOsE: To investigate the possible role of AMPK for the energy substrate<br />
selection in post exercise recovery.<br />
METhOds: Homozygote AMPKα2 knock-out (KO) and wildtype (WT) littermates<br />
were allocated into 3 groups: a resting control group, an exercise group and a postexercise<br />
group. Treadmill exercise was performed for 2 hours at 50% of maximal<br />
running capacity for each group. Post-exercise recovery group was studied 6 hours post<br />
exercise. Oxygen uptake and respiratory exchange ratio were measured in metabolic<br />
chambers during both resting, exercise and in post-exercise recovery conditions.<br />
rEsuLTs: In both genotypes RER was lower (p
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