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Acknowledgement<br />

First of all, I would like to express my appreciations and gratitude to my supervisor<br />

Professor Ahmed Al-Jumaily, for his ongoing guidance and patience. I would also like<br />

to express my appreciations and gratitude to Dr. Roy Nates for so much valuable helps<br />

and so much time in checking and correcting this thesis to details.<br />

I would also like to thank my industrial supervisors at Fisher & Paykel Healthcare, Mr.<br />

Doug Makinson and Dr. Andrew Somervell. Their helps and suggestions too, have been<br />

very valuable. So much thanks also to Mr. Ian Sun for tolerating me and helping me in<br />

my quest.<br />

Thanks to Alex Du, Gijs Ijpma, Hai Lan, Ashis Mookerjee, Max Ramos and Prasika<br />

Reddy at The Institute of Biomedical Technologies for their ideas and helps. Thanks to<br />

Joe El-Aklouk for various helps and later Tim Fulcher. Thanks also to my classmates<br />

Linda Liu and Danyi Liu, we encouraged each other during the course of the thesis.<br />

Sincere thanks to all the people who sincerely helped me in this thesis.<br />

My deepest thanks to my wife Shujie Wang and my daughter Minrong Li. I could not<br />

have completed the thesis without their understanding and support. I owe them so many<br />

evenings and weekends I should accompany them. Deepest thanks also to my father<br />

Defang Li, mother Jinyu Liu.<br />

iii

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