TiHo Bibliothek elib - Tierärztliche Hochschule Hannover

Untersuchung des Chemokins MIP-3 β/CCL19
Abbreviations: IE = idiopathic epilepsy; CSF = cerebrospinal fluid; MIP3β =
macrophage inflammatory protein-3β; pg = picogram; ml = milliliter
MIP-3β/ CCL19 CSF concentration in inflammatory diseases
Highly elevated CCL19 concentrations were observed in CSF samples of untreated
SRMA and MUO patients compared to the control group (IE/ healthy)
(p < 0.001; median SRMA: 1690 pg/ml; MUO: 373.5 pg/ml) as shown in figure 2,
figure 3 and table 1. Dogs under therapy had significantly lower CCL19 values
compared to the patients without therapy (p < 0.001). Treated SRMA dogs (p =
0.026) differ significantly from the controls while treated MUO patients did not differ
significantly (p = 0.059). Patients which received one injection with glucocorticosteroids
before initial examination had significantly less CCL19 levels (p =
0.0259) compared to entirely untreated animals. The subgroup of patients having a
relapse did not differ statistically (p = 0.4864) from untreated patients (fig. 2 and fig.
3).
Fig. 2 MIP3β/ CCL19 CSF concentrations of patients with SRMA compared to the
control group.
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