Protocol for the Derivation of Environmental and Human ... - CCME

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Part C, Section 2 Section 2 Investigation of Contaminant Toxicology Health Canada has determined the reference dose {Tolerable Daily Intake (TDI) for threshold substances and Risk Specific Doses (RSD) associated with risks of 10 -4 , 10 -5 , 10 -6 and 10 -7 for nonthreshold substances} for all contaminants being addressed by the NCSRP. Some important aspects of developing TDI and RSDs are described in Section 2. Hazard assessment determines the health effect potentially attributable to a contaminant (e.g., carcinogenic, hepatotoxic, teratogenic) and estimates the reference dose believed to be associated with a defined level of incidence of that effect in the population. For a threshold substance, exposure less than the reference dose should pose a zero probability of incidence of an adverse effect in the population. For a non-threshold substance (i.e., a carcinogen or a germ cell mutagen), the critical risk specific dose may define a risk level of 1 in 1 million. Methods of chemical evaluation employed by the Environmental Health Directorate of Health Canada, are described in Richardson and Myers (1993), Armstrong and Newhook (1992), Meek (1989), Environmental Health Directorate (1989, 1990, 1991) and Health Canada (1994). The toxicological evaluation and exposure assessment can typically fit within a generalized framework for human health risk assessment (see Figure 16). Toxic effects from exposure to environmental contaminants may be classified in the following broad categories: • organ-specific, • neurological/behaviourial, • reproductive/developmental, • immunological, carcinogenic, and mutagenic. These effects can be manifested at the biochemical, cellular, histopathological, and morphological levels. Effects vary, depending upon the dosage, route of exposure (e.g., ingestion, inhalation, or dermal contact), frequency and/or duration of exposure, species (and strain in the case of some animals), physiological state, sex, and age of the exposed population. Toxicological effects from exposure to chemical substances may be brief or prolonged, reversible or irreversible, immediate or delayed. The nature, number, severity, incidence and/or prevalence of specific toxicological effects in populations (of either humans or animal species) exposed to various chemicals generally increase with increasing dose or level of exposure; this is commonly referred to as the exposure- or dose-response relationship. For most environmental contaminants, data on the toxicological effects resulting from exposure are restricted to information obtained from studies involving experimental animals. Occasionally, information derived from studies of human populations (principally epidemiological investigations) forms an integral part of the database upon which the assessment is based. Clearly, data on direct effects in humans are 70
preferred for the assessment, but since data are limited or inadequate, extrapolation across species remains the rule. 71
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A Protocol for the Derivation of En
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Readers' Comments The Canadian Coun
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Overview In response to growing pub
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mechanisms for migration of soil co
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procédures d'élaboration des reco
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• être absorbés par les plantes
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PART B Section 1 Derivation of Envi
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Section 2 Investigation of Contamin
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PART D Section 1 Derivation of the
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List of Figures 1 National Framewor
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Acknowledgements The CCME Subcommit
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Document Organization This document
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Bioaccumulation: The process by whi
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Denitrification: The gaseous loss o
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GGG Guidelines: Generic numerical l
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Mutagenicity: The ability of a chem
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xxxiv human exposure. Risk estimati
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Soil: Normally defined as the uncon
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VVV Volatilization: The chemical pr
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Section 1 The National Contaminated
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Part A, Section 1 6
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Part A, Section 1 1.2.2.2 Remediati
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Part A, Section 1 of, and establish
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Part A, Section 2 Section 2 Nationa
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Part A, Section 2 2.2 Limitations o
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Part A, Section 2 17
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Part A, Section 2 Industrial: where
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• the sensitivity of the test con
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Part A, Section 3 23
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Section 2 Level of Ecological Prote
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Part B, Section 2 2.3 Endpoint Defi
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Part B, Section 2 There is consiste
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Part B, Section 4 Section 4 Potenti
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Part B, Section 4 Figure 4 Simplifi
Page 75 and 76: Figure 5 Key Receptors and Exposure
Page 77 and 78: Part B, Section 5 grazing herbivore
Page 80 and 81: Part B, Section 5 5.2.2 Maintenance
Page 82 and 83: Part B, Section 5 5.4 Industrial La
Page 84 and 85: Section 6 Uncertainty in Guidelines
Page 86 and 87: Section 7 Guidelines Derivation Pro
Page 88 and 89: Part B, Section 7 (SQG SG = soil qu
Page 90 and 91: Part B, Section 7 a soil quality gu
Page 92 and 93: Where: NPER = no to Potential Effec
Page 94 and 95: Part B, Section 7 7.5.2.1 Using Mic
Page 96 and 97: Part B, Section 7 data, the Median
Page 98 and 99: Part B, Section 7 EC 50 LC 50 UF =
Page 100 and 101: Where: ERL = Effects Range Low, ECL
Page 102: Part B, Section 7 Where: EC 50 = Me
Page 105 and 106: Part B, Section 7 Where the ECL lie
Page 107 and 108: Part B, Section 7 4. Fewer than thr
Page 110 and 111: Part B, Section 7 An uncertainty fa
Page 112 and 113: Part B, Section 7 Therefore, BCF =
Page 114 and 115: Part B, Section 7 ingestion (SQG I
Page 117 and 118: Section 8 Derivation of the Final E
Page 119 and 120: Part C, Section 1 65
Page 121 and 122: Part C, Section 1 various sites acr
Page 123: Part C, Section 1 Geographical unce
Page 129 and 130: Part C, Section 2 Environmental con
Page 131 and 132: Part C, Section 2 extent, the steep
Page 133 and 134: Section 3 Exposure to Contaminants
Page 137 and 138: Part C, Section 4 Section 4 Exposur
Page 139 and 140: Part C, Section 4 within limits, th
Page 141 and 142: Part C, Section 4 Figure 19 Concept
Page 143 and 144: Part C, Section 4 4.2 Absorption of
Page 145 and 146: Part C, Section 4 In the case of no
Page 148 and 149: Residential/Parkland Land Use Sensi
Page 150 and 151: Part C, Section 4 Commercial Land U
Page 152: Part C, Section 4 Industrial Land U
Page 155 and 156: Part C, Section 5 these data are av
Page 157 and 158: Part C, Section 5 GEOCHEM (Mattigod
Page 159 and 160: Part C, Section 5 • K oc (sorptio
Page 161 and 162: Part C, Section 5 5.3.3 Evaluation
Page 163 and 164: Part C, Section 5 parameters, and s
Page 165 and 166: Section 6 Derivation of the Final H
Page 167 and 168: Part D, Section 1 101
Page 169 and 170: does not apply to the commercial or
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References Aldenberg, T., and W. Sl
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References -dwelling Organisms", Ab
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References 112
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References Hill, E.F., and D.J. Hof
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References Paustenbach, D.J., (1989
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References Summers, J.K., H.T. Wils
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Appendix A Appendix A Nutrient and
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Appendix A Figure A.1 Simplified Te
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Appendix A 4.1 Agricultural and Res
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Appendix A References Bååth, E.,
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The Subcommittee considers that exp
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Appendix B P l P r BW = percent pro
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Appendix B Substituting equation 5
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Appendix B Where no MRL exists, the
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Appendix B Then, the remainder (T R
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Appendix B For carcinogens, total i
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Appendix C Rearranging [2] and subs
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Appendix C References Chiou, C.T.,
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Appendix D uncontaminated organic m
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Appendix D R = recharge, m/yr A = a
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Appendix D 2.3.3 Hydraulic Gradient
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Appendix D 2.3.5 Site Length The le
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Appendix D Table D.2 Lower Quantile
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Figure D.2 Conceptual Model of Dilu
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Appendix D Figure D.3 Recharge Esti
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Appendix D 159
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Smith, A.E., P.B. Ryan, and J.S. Ev
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Appendix E C K L V is the climate f
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Appendix E contaminant concentratio
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Appendix F Appendix F Multi-media E
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Appendix F example, fish BCFs are t
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Appendix G 2.2 Contaminant Vapour T
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Appendix G Table G.1 Equations Used
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Appendix G at the outset that, rath
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Appendix G 4.4 Application of the R
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Average outdoor summer temperature
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Appendix G References Alberta Envir
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