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Protocol for the Derivation of Environmental and Human ... - CCME

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Bioaccumulation: The process by which chemical compounds are<br />

taken up by terrestrial <strong>and</strong> aquatic organisms directly from <strong>the</strong><br />

medium <strong>and</strong> through consuming contaminated food.<br />

Bioassay: A controlled, experimental study in which organisms<br />

(typically rodents) are exposed to several different<br />

doses/concentrations <strong>of</strong> a chemical over a predetermined time<br />

(see long- <strong>and</strong> short-term exposure), <strong>and</strong> <strong>the</strong> resulting effects<br />

are identified <strong>and</strong> measured.<br />

Bioavailability: The amount <strong>of</strong> chemical available to <strong>the</strong> target tissues<br />

following exposure.<br />

Bioconcentration: The process by which contaminants are directly<br />

taken up by terrestrial <strong>and</strong> aquatic organisms from <strong>the</strong> medium.<br />

Biomagnification: The process <strong>of</strong> bioaccumulation by which tissue<br />

concentrations <strong>of</strong> accumulated chemical compounds are passed<br />

up through two or more trophic levels so that tissue residue<br />

concentrations increase systematically as trophic level increases.<br />

Biota: Biological organisms (including plants, microbes, invertebrates,<br />

<strong>and</strong> animals).<br />

CCC<br />

Carcinogen: A substance or agent that causes <strong>the</strong> development or<br />

increases <strong>the</strong> incidence <strong>of</strong> cancer. A carcinogen can also act<br />

upon a population to change its total frequency <strong>of</strong> cancer in<br />

terms <strong>of</strong> numbers <strong>of</strong> tumours or distribution by site <strong>and</strong> age.<br />

Carcinogenic: Of or pertaining to <strong>the</strong> ability to cause <strong>the</strong> development<br />

<strong>of</strong> cancer.<br />

Carcinogenic potency: Expressed as a concentration or dose that<br />

induces a 5% increase in <strong>the</strong> incidence <strong>of</strong>, or death due to<br />

tumours or heritable mutations associated with exposure.<br />

Cation exchange capacity: The total amount <strong>of</strong> exchangeable cations<br />

that a soil can absorb.<br />

Cation exchange: The interchange between a cation in solution <strong>and</strong><br />

ano<strong>the</strong>r cation on <strong>the</strong> surface <strong>of</strong> any surface-active material<br />

(e.g., clay or colloidal organic matter).<br />

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