Protocol for the Derivation of Environmental and Human ... - CCME
Protocol for the Derivation of Environmental and Human ... - CCME
Protocol for the Derivation of Environmental and Human ... - CCME
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
Appendix B<br />
carcinogenic, <strong>the</strong>n <strong>the</strong> total exposure should not exceed <strong>the</strong> risk specific dose <strong>for</strong> a cancer risk <strong>of</strong> 10 -6 .<br />
The equations <strong>for</strong> this estimation are given in <strong>the</strong> following Section 4.1.<br />
4.1 Non-carcinogens<br />
Agricultural Site<br />
For an agricultural site, <strong>the</strong> Subcommittee proposed that 100% <strong>of</strong> <strong>the</strong> milk, <strong>and</strong> 50% <strong>of</strong> garden produce<br />
<strong>and</strong> meat are produced or grown on site. The total intake <strong>of</strong> contaminant is calculated based on <strong>the</strong>se<br />
assumptions. These estimates provide <strong>the</strong> total (background <strong>and</strong> on-site) exposure from those food<br />
sources. Generic guidelines <strong>for</strong> an agricultural setting are assumed to protect against exposure from local<br />
garden produce, <strong>and</strong> meat <strong>and</strong> milk.<br />
I p = intake <strong>of</strong> contaminant from produce grown on-site + intake <strong>of</strong> contaminant from produce<br />
grown <strong>of</strong>f-site<br />
I b = intake <strong>of</strong> contaminant from meat produced on-site + intake <strong>of</strong> contaminant from meat<br />
produced <strong>of</strong>f-site<br />
I m = intake <strong>of</strong> contaminant from milk produced on-site + intake <strong>of</strong> contaminant from milk<br />
produced <strong>of</strong>f site<br />
In estimating <strong>the</strong> total intake <strong>of</strong> a contaminant from all food sources at an agricultural site, <strong>the</strong><br />
background intake <strong>of</strong> produce, meat, <strong>and</strong> milk must be removed because <strong>the</strong> above equations include<br />
on-site <strong>and</strong> <strong>of</strong>f-site exposure.<br />
Where:<br />
T R = T F - (I BP + I BB + I BM ) [12]<br />
T R = Total estimated intake <strong>of</strong> contaminant from food o<strong>the</strong>r than produce, meat, <strong>and</strong><br />
milk<br />
T F = Total estimated intake <strong>of</strong> contaminant from food (from multi-media exposure<br />
assessment)<br />
I BP = Background intake <strong>of</strong> contaminant in produce (from multi-media exposure<br />
assessment)<br />
I BB = Background intake <strong>of</strong> contaminant in meat (from multi-media exposure<br />
assessment)<br />
I BM = Background intake <strong>of</strong> contaminant in milk (from multi-media exposure<br />
assessment)<br />
135