June 27, 2007 EUROPEAN JOURNAL OF MEDICAL RESEARCH 81 D.6 (Vortrag) Recovery <strong>of</strong> CD4+ T-cells after switch to a nucleoside free regimen in patients with poor immunologic response despite complete HIV-RNA suppression Lehmann C. 1 , H<strong>of</strong>mann A. 1 , Cornely O. 1 , Jung N. 1 , Hartmann P. 1 , Norbert S. 1 , Wyen C. 1 , Fätkenheuer G. 1 1 Medizinische Klinik I, Klinische Infektiologie, Universität zu Köln, Köln, Germany Background: Antiretroviral Therapy (ART) usually leads to suppression <strong>of</strong> HIV load and rapid rise <strong>of</strong> CD4+ T- cell count. However, in some patients poor recovery <strong>of</strong> CD4+ T- cell despite optimal viral suppression on ART is observed. As some combinations <strong>of</strong> nucleoside analogues (NA) have been associated with paradoxical depletion <strong>of</strong> CD4+ T- cells, we postulated that the change from a NA containing to a NA free regimen could improve quantitative immunological parameters. Methods: 15 HIV-1 infected patients on NA containing ART with undetectable HIV load and CD4+ T-cells < 250/L for at least 6 months were included in this study after informed consent. Treatment was switched to Atazanavir (ATV) (300mg qd), Saquinavir (SQV, 1000mg bid) and Ritonavir (RTV, 100mg qd) Results: Median [IQR], age [yrs.]: 46 [38-62]; gender: male: n=11, CDC stage C3: n= 9, CD4+ T-cells/L at baseline: 197 [130-220], 10% [7-17]; months on ART: 20, [6-114]. The regimen was well tolerated. 1 patient discontinued because <strong>of</strong> incompliance. HIV RNA remained below 50 copies in 14 patients and CD4+ T-cell count improved significantly, (week 24: 230L (14%), [170-290, 10-17%], week 48: 260/l, 17% [195-415, 13.5-18.5%] p< 0.05) Conclusions: This clinical pilot study shows that the boosted double PI combination <strong>of</strong> ATV/SQV without the addition <strong>of</strong> NA may be an effective and generally well-tolerated NAsparing treatment strategy for patients with poor immunologic response despite undetectable viraemia. D.7 (Vortrag) Long-term response on CD4 T-cell count recovery in HIV-infected patients receiving highly active antiretroviral therapy (HAART) Kramer K. 1 , Vogel M. 1 , Voigt E. 1 , Wasmuth J. 1 , Schwarze-Zander C. 1 , Rockstroh J. 1 1 Department <strong>of</strong> Medicine I, University <strong>of</strong> Bonn, Bonn, Germany Objective: Several valid options for HAART initiation exist for the treatment naïve, HIV-infected individual. Currently however, there is an ongoing controversy over the potency <strong>of</strong> NNRTI vs. PI based regimens on immune reconstitution. We examined the potential superiority <strong>of</strong> one <strong>of</strong> these therapy arms. Methods: Single cohort study. Retrospective chart review. CD4 T-cell count was analyzed every 3 months in participants who had been HAART-naïve at the time point <strong>of</strong> HAART initiation and had a plasma HIV RNA load
82 EUROPEAN JOURNAL OF MEDICAL RESEARCH June 27, 2007 (p
- Page 1 and 2:
European Journal of Medical Researc
- Page 3 and 4:
Instructions to Authors 1. The Euro
- Page 6 and 7:
June 27, 2007 EUROPEAN JOURNAL OF M
- Page 8 and 9:
June 27, 2007 EUROPEAN JOURNAL OF M
- Page 10 and 11:
June 27, 2007 EUROPEAN JOURNAL OF M
- Page 12 and 13:
June 27, 2007 EUROPEAN JOURNAL OF M
- Page 14 and 15:
June 27, 2007 EUROPEAN JOURNAL OF M
- Page 16 and 17:
June 27, 2007 EUROPEAN JOURNAL OF M
- Page 18 and 19:
June 27, 2007 EUROPEAN JOURNAL OF M
- Page 20 and 21:
June 27, 2007 EUROPEAN JOURNAL OF M
- Page 22 and 23:
June 27, 2007 EUROPEAN JOURNAL OF M
- Page 24 and 25:
June 27, 2007 EUROPEAN JOURNAL OF M
- Page 26 and 27:
June 27, 2007 EUROPEAN JOURNAL OF M
- Page 28 and 29:
June 27, 2007 EUROPEAN JOURNAL OF M
- Page 30 and 31:
June 27, 2007 EUROPEAN JOURNAL OF M
- Page 32 and 33:
June 27, 2007 EUROPEAN JOURNAL OF M
- Page 34 and 35:
June 27, 2007 EUROPEAN JOURNAL OF M
- Page 36 and 37:
June 27, 2007 EUROPEAN JOURNAL OF M
- Page 38 and 39: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 40 and 41: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 42 and 43: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 44 and 45: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 46 and 47: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 48 and 49: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 50 and 51: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 52 and 53: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 54 and 55: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 56 and 57: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 58 and 59: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 60 and 61: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 62 and 63: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 64 and 65: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 66 and 67: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 68 and 69: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 70 and 71: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 72 and 73: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 74 and 75: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 76 and 77: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 78 and 79: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 80 and 81: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 82 and 83: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 84 and 85: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 86 and 87: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 90 and 91: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 92 and 93: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 94 and 95: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 96 and 97: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 98 and 99: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 100 and 101: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 102 and 103: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 104 and 105: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 106 and 107: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 108 and 109: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 110 and 111: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 112 and 113: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 114 and 115: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 116 and 117: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 118 and 119: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 120 and 121: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 122 and 123: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 124 and 125: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 126 and 127: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 128 and 129: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 130 and 131: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 132 and 133: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 134 and 135: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 136 and 137: June 27, 2007 EUROPEAN JOURNAL OF M
- Page 138 and 139:
June 27, 2007 EUROPEAN JOURNAL OF M
- Page 140 and 141:
June 27, 2007 EUROPEAN JOURNAL OF M
- Page 142 and 143:
June 27, 2007 EUROPEAN JOURNAL OF M