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108<br />
117 <br />
OGAMI<br />
<br />
<br />
1,2 1 Takako Kondo 2 Eri Hashino 2<br />
1<br />
2 Dept. OtolaryngologyHNS, Indiana<br />
Univ. Sch. Med.<br />
95<br />
<br />
<br />
Wnt <br />
<br />
<br />
in vivo Tlx3<br />
<br />
<br />
Tlx3 <br />
<br />
Tlx3 <br />
Tlx3 Wnt <br />
<br />
<br />
Tlx3 <br />
Tlx3 <br />
<br />
OGAMI<br />
<br />
1 1 1 2 1 2 <br />
1 1 2 1<br />
1<br />
2 <br />
<br />
ES iPS <br />
<br />
<br />
<br />
<br />
<br />
Multilineage differentiating stress enduring Muse cell<br />
<br />
Muse ES <br />
Cluster Cluster <br />
3 <br />
<br />
3 <br />
<br />
SSEA3<br />
<br />
Muse <br />
<br />
<br />
OGAMI<br />
<br />
1 2 1 1 3 1<br />
1<br />
2 3 <br />
<br />
ES inner cell mass<br />
<br />
<br />
<br />
<br />
<br />
<br />
3 <br />
<br />
<br />
Oct3/4, OctA, Klf4, Nanog, cMyc, BCRP,<br />
Sox2, CK5, vimentin <br />
vimentin <br />
<br />
vimentin Oct3/4 <br />
23 ALP <br />
<br />
<br />
<br />
OGAMI<br />
<br />
1 2 1<br />
1<br />
2 <br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
<br />
6 <br />
9 <br />
10 μl <br />
<br />
10 <br />
<br />
<br />
2 mm <br />
5 mm <br />
2010 mm <br />
<br />
OGAMII<br />
The application of antimicrobials or glycogen accelerates the pulpal<br />
regeneration of replanted molars in mice<br />
Angela QuispeSalcedo, Hiroko IdaYonemochi, Hayato Ohshima<br />
Div. of Anatomy and Cell Biology of the Hard Tissue, Dept. of Tissue<br />
Regeneration and Reconstruction, Niigata Univ. Grad. Sch. of Med. and Dent. Sci.<br />
The intentionally prolonged time for the completion of tooth replantation<br />
induces bone formation, expanded inflammatory reaction, or fibrous tissue<br />
formation in pulp tissue. This study aims to clarify the effect of a combination<br />
of metronidazole, ciprofloxacine, and minocycline 3Mix or enzymatically<br />
synthesized glycogen ESG solution on the pulpal healing of replanted teeth.<br />
After extraction of the upper first molars of mice, the teeth were immersed in<br />
3Mix solution at four different concentrations standard, 50%, 75%, and 90%<br />
during 5 to 60 minutes with or without the use of a transfer solution PBS; and for<br />
60 min in ESG solution in addition to PBS alone control. Immunohistochemistry<br />
for nestin verified tertiary dentin formation 1 week after operation in the 3Mix<br />
groups and at 2 weeks in the ESG group. In contrast, no tertiary dentin formation<br />
was observed at 2 weeks in the control. Standard concentration of 3Mix induced<br />
severe ankylosis of the replanted tooth, in spite of the accelerated dentinogenesis.<br />
In conclusion, the application of 3Mix or ESG promotes the pulpal regeneration of<br />
replanted teeth, although the 3Mix may induce severe damage to the periodontal<br />
tissue.<br />
OGAMII<br />
<br />
1 2 1<br />
1<br />
<br />
2<br />
<br />
<br />
<br />
ESG <br />
ESG <br />
ESG <br />
<br />
<br />
ICR ESG 2 mg/mLESG<br />
3 <br />
3714 <br />
<br />
ESG <br />
<br />
ESG <br />
14 ESG 3 <br />
<br />
ESG DSPP <br />
ESG
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