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162 117 P IVCT FS IgA Ig -193 IVCT 2% PFA FS 2%PFA 2%PFA - - PFDH - HE IgA IgG1 Ig κ Lκ IgM IVCT HE IgA IgLκ IgG1 IgM IgG1 PFDH IgA IVCTFS P M Epidermal type FABP EFABP/FABP 1 2 1 1 2 Fatty acid binding protein FABP Epidermal type FABP EFABP/FABP5 M Histochem Cell Biol. vol.1326, 2009 M 17 18 116 M 16, 17, 18, 19 IgA IgA EFABP M EFABP EFABP galectin4 M EFABP galectin4 P A 1 2 1 1 1 1 2 1 1 2 Lampreys are ancestral representatives of vertebrates known as jawless fish. The Japanese lamprey, Lethenteron japonicum, is a parasitic member of the lampreys known to store large amounts of vitamin A within its body. How this storage is achieved, however, is wholly unknown. Within the body, the absorption, transfer and metabolism of vitamin A are regulated by a family of proteins called retinoid binding proteins. Here we have cloned a cDNA for cellular retinolbinding protein CRBP from the Japanese lamprey, and phylogenetic analysis suggests that lamprey CRBP is an ancestor of both CRBP I and II. The lamprey CRBP protein was expressed in bacteria and purified. Binding of the lamprey CRBP to retinol Kd of 13.2 nM was identified by fluorimetric titration. However, results obtained with the protein fluorescence quenching technique indicated that lamprey CRBP does not bind to retinal. Northern blot analysis showed that lamprey CRBP mRNA was ubiquitously expressed, although expression was most abundant in the intestine. Together, these results suggest that lamprey CRBP has an important role in absorbing vitamin A from the blood of host animals. P cKIT ICC ICC cKIT ICC αSMA cKIT αSMA E11.5 12 cKIT E11.5 E12.5 cKIT αSMA E13.5 cKIT αSMA E15.5 αSMA cKIT αSMA E18.5 E14.5 E16.5 αSMA cKIT αSMAcKIT P ICCSP Interstitial cells of Cajal: ICC Subserosa: SS ICC ICCSS Submucosal Plexus: SP ICC ICCSP ICCSP ICC ICCSP P CCK CCK CCK1 CCK1 CCK1 in situ hybridization CCK1 CCK G CCK1 CCK
117 163 P The metabolism of cholesterol after bile duct degeneration in lamprey Mayako Morii 1 , Yoshihiro Mezaki 2 , Noriko Yamaguchi 2 , Kiwamu Yoshikawa 2 , Mitsutaka Miura 2 , Katsuyuki Imai 2 , Taku Hebiguchi 1 , Ryo Watanabe 1 , Hiroaki Yoshino 1 , Haruki Senoo 2 1 Department of Pediatric Surgery, Akita University Graduate School of Medicine, 2 Department of Cell Biology and Morphology, Akita University Graduate School of Medicine Lampreys are unique vertebrates in that they lose biliary trees entirely during the metamorphosis. Despite the biliary atresia, lampreys do not develop neither biliary cirrhosis nor liver dysfunction. In other vertebrates, obstruction of bile ducts results in fatality because of the cytotoxicity of bile salts. It means that lampreys have evolved to use another metabolic pathway of bile juice in order to evade the cholestasis. However, molecular mechanism of this pathway is still unknown. The aim of this study is to investigate the way how the lamprey avoid the pathological consequence of cholestasis. We have cloned the cDNA sequences of two kinds of P450, which show high degree of homology with mammalian CYP7A1 and CYP27A1, respectively. We are now evaluating the expression levels of the mRNA for these genes in liver, gonad, gill, heart and intestine along with the temporal expression profiles from larva to adult. The present study suggests how and where bile acids are detoxified in adult lampreys. Understanding how lampreys avoid cholestasis could be valuable for progress in the treatment of human obstructive cholangiopathy. P NAFLD 1 1 1 2 1 1 2 NAFLD NAFLD NASH NAFLD NASH 9 C57BL/6 MCD 30 M R MCD 8 16 30 2 AST, ALT M 2 AST, ALT NAFLD 10 M 16 CD68 CD68 R 3 R 16 MCD 16 CD68 30 CD68 P Deltalike Deltalike3 DLL3 DLL3 Huh2 DLL3 AnexinV TUNEL singlestrand DNA DLL3 Huh2 DLL3 binding assay DLL3 Small G Cdc42 CRIB DLL3 HuH2 Cdc42 PAK1 MAP kinase DLL3 DLL3 Cdc42 PAK1 MAP kinase P 1 2 2 2 1 1 2 CLD ICR 85O 2 RA21Air 14 RA 7 RA14 Air14d 14 O 2 14dRA 21 Air21dO 2 Air21d 4%PFA O 2 14d O 2 Air21d CLD P CEACAM 1 Nabil Eid 1 2 1 1 1 2 prox1 Carcinoembryonic cell adhesion molecule1 CEACAM1 CEACAM1 VEGFC BJMC338 VEGFC BJMC3879 2 CEACAM1, VEGFR3VEGFR3 phosphotyrosine VEGFA BJMC3879 CEACAM1 BJMC3879 CEACAM1 BJMC338 BJMC3879 BJMC3879 VEGFR3 BJMC3879 CEACAM1 VEGFC P The role of peritoneal lymphatic system on the human peritoneal dissemination Masahiro Miura 1 , Yutaka Yonemura 2 , Yoshio Endou 3 1 Department of Human Anatomy, Faculty of Medicine, Oita University, 2 NPO organization to support peritoneal dissemination treatment, 3 Department of Molecular Targeting Therapy, Kanazawa University The role of lymphatic microenvironment on cancer metastasis was studied. VEGFCgene transfectants of the gastric cancer cell lines were inoculated into the peritoneal cavity of nude mice. The tissue samples from human disseminated peritoneum were stained with 5,NaseALPase double staining and aniti VEGFR3 immunostaining. Mouse VEGFR3 gene expression was induced after inoculation. In the early peritoneal dissemination PD stage, newly lymphatic networks LN were detected in the periphery of the primary tumor. The main source of lymphatic dissemination may originate from the peritumoral LN. In the PD, three patterns of tumor lymphangiogenesis, namely centrifugal, centripetaland combination growth patterns were found. Free cancer cells invaded the numerous blind endings that came from extended subperitoneal LN. In the late PD stage, the number of LN decreased due to the destruction of cancer cells. In SEM observation, Macula cribriformis were seen in the diaphragmatic subperitoneal tissue layer and Morrison pouch. Lymphangioginesis including newly formed LN, induced by VEGFC is closely associated in formation of PD and lymph node metastasis mainly via the prelymphatic channels.
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