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114 117 ODPMII OEPMVI 1,2 1,2 1,2 1,2 1,2 1 2 IdaEto et al., Neurosci. Lett., in press 9 Wistar 15 2 OEPMVI Developmental Origins of Health and Disease DOHaD Randeep Rakwal DOHaDDevelopmental Origins of Health and Disease ADHD 50% 1018 17 18 mRNA DyeSwap DNA 250 1300 140 GABA A neuromedin BStat1 T OEPMVI 1 - 1 1 1,2 1 1 2 PTSD maternal separation: MS cFos MS 2 3 / MS repeated MS: RMS 2 MS single MS:SMS cFos RMS SMS cFos RMS SMS MS MS OEPMVI q E/I 1,2 1,4 1 1 1 3 3 5 1,2,6 1 2 3 4 Heidelberg University, Germany 5 6 JST,CREST 15q11q13 20 / Excitation/Inhibition, E/I E/I E/I VGLUT1 Vesicular glutamate transporter 1 VGAT Vesicular GABA Transporter VGAT VGLUT1 E/I OEPMVII DNA BromodeoxyuridineBrdU 2 BrdU 2 1 2 Notch1 Notch1 Notch1
117 115 OEPMVII 1 1 2 2 1 1 2 experimental autoimmune encephalomyelitis: EAE EAE C57BL/6 Myelin oligodendrocyte glycoprotein 3555 MOG3555 EAE EAE EAE OEPMVII RAGE Receptor for advanced glycation end productsRAGE RAGE RAGE BCCAORAGE RAGE esRAGERAGE 3 BCCAO BCCAO 12 3-7 RAGE RAGE esRAGE 24 7 12 RAGE OEPMVIII Fasting and highfat diet alter histone deacetylase expression in the medial hypothalamus Increasing attention is now being given to the epigenetic regulation of animal and human behaviors including the stress response and drug addiction. Histone deacetylases HDACs are involved in the epigenetic control of gene expression and alter behavior in response to a variety of environmental factors. In response to fasting and highfat diets, the expression of both orexigenic and anorexigenic neuropeptides change in the medial hypothalamus, a crucial region for feeding behavior and body weight homeostasis. However, the mechanism by which gene expression is modulated in the medial hypothalamus remains to be clarified. Here, we examined the expression of HDAC family members in the medial hypothalamus of mice in response to either fasting or a highfat diet. In response to fasting, HDAC3 and 4 expression levels increased while HDAC10 and 11 levels decreased. Four weeks on a highfat diet resulted in the increased expression of HDAC5 and 8. Therefore, HDACs may be implicated in altered gene expression profiles in the medial hypothalamus under different metabolic states. OEPMVIII 1 2 3 1 1 2 3 1 2 3 1 2 PGP9.5 CGRP 1/3 Aδ C 1/21/3 CGRP C OEPMVIII PAM 1,2 1 1 1 2 PAMPressure Application Measurement Randall Selitto PAM 5 6 NSAIDs 10 1 2 3 NSAIDs PAM cFos OFPMVI 1 Watson Eileen 2 1 1 2 Dept. Oral Health Sciences, University of Washington Proteaseactivated receptor PAR G 7 PAR PAR PAR RTPCR PAR2 PAR2 SLIGRLNH 2 [Ca 2+ ] i Ca 2+ [Ca 2+ ] i Ca 2+ noncapacitative calcium entry NCCE Ca 2+ NOS LNAME ADP calmodulin kinase II CAMK II calmodulin [Ca 2+ ] i PAR2 [Ca 2+ ] i NOS Calmodulin CAMK II
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117 5 100 http://yamanashiko
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117 9 1117TEL: 0552541000 URL:
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26 117 ::B M 15 30
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28 S S S S 117 ex vivo
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30 S 117 Coordinated branching mo
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32 117 ::A M M S. 2
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34 117 ::A M M S. S
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36 117 S kisspeptin S
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38 117 S S ::B M M S.
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40 117 E L C LC ::OEPM I
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42 117 E L C LC ::OEAM III
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44 117 2OHAMIII2 2OHAMIII3 1
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46 117 F L C LC ::OFPM VI 3
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48 117 :: I 1P001 S100A
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50 117 1P073 Makoto Naganuma Acti
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52 117 2P018 Conserved properti
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54 117 2P090 2P091 2P092
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56 117 3P027 3P028 ABC 3P0
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58 117 :: 3P102 3P103
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117 59 100 μm 20 nm 1 μ
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117 61 12 345
Page 71 and 72: 117 63 SM G
Page 73 and 74: 117 65 S Physiological roles of ce
Page 75 and 76: 117 67 S 1,2 1 1 2 JST S
Page 77 and 78: 117 69 S The role of autophagyrela
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Page 81 and 82: 117 73 S 3D 2 3D 3
Page 83 and 84: 117 75 S 1 2 1 1 1
Page 85 and 86: 117 77 S GSK3β gl
Page 87 and 88: 117 79 S niche DNA endos
Page 89 and 90: 117 81 S GABA GABA Cl KCC2C
Page 91 and 92: 117 83 S By means of retrograd
Page 93 and 94: 117 85 S S
Page 95 and 96: 117 87 S 1,2,3 1 2 CREST, JS
Page 97 and 98: 117 89 S C 1 1 2 1 2 1
Page 99 and 100: 117 91 S Focused Ion BeamScanning
Page 101 and 102: 117 93 S 2
Page 103 and 104: 117 95 S S
Page 105 and 106: 117 97 W WG 1,2 1 2 WG
Page 107 and 108: 117 99 OEPMI Singleneuron tracing
Page 109 and 110: 117 101 OFPMII 1 2 3 2
Page 111 and 112: 117 103 OHPM Two immunogenic passe
Page 113 and 114: 117 105 OEAMIII PHAL
Page 115 and 116: 117 107 OFAMIV 1 1 1 2
Page 117 and 118: 117 109 OGAMII BrdU Labelr
Page 119 and 120: 117 111 OHAMIII 1 2 2 2
Page 121: 117 113 ODPMI Large Maf Large
Page 125 and 126: 117 117 OFPMVIII α
Page 127 and 128: 117 119 OHPMIV 1
Page 129 and 130: 117 121 OIPMIV 1 2 1 1
Page 131 and 132: 117 123 P SA 1 2 1 2 Glial
Page 133 and 134: 117 125 P γ 4,52 P
Page 135 and 136: 117 127 P cFos 1 2 1 1
Page 137 and 138: 117 129 P Identification of CSPG c
Page 139 and 140: 117 131 P NOS 1 2 4 4
Page 141 and 142: 117 133 P DPEP 1 2 2 1
Page 143 and 144: 117 135 P Activities of human uppe
Page 145 and 146: 117 137 P 2010 77 2
Page 147 and 148: 117 139 P Nacholapithecus kerioi
Page 149 and 150: 117 141 P kirrel 1 1 1
Page 151 and 152: 117 143 P prechordal chond
Page 153 and 154: 117 145 P FIB/SEM 1,3 1 2
Page 155 and 156: 117 147 P VIP 12 VIP
Page 157 and 158: 117 149 P Motor protein KIFA is es
Page 159 and 160: 117 151 P parvic
Page 161 and 162: 117 153 P SEM 75 mM KC
Page 163 and 164: 117 155 P mAtgAAcGFP mDFCPmCherry
Page 165 and 166: 117 157 P αMangostin 1 2
Page 167 and 168: 117 159 P 1 1 1 1 2 1
Page 169 and 170: 117 161 P planar cell polarity
Page 171 and 172: 117 163 P The metabolism of choles
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117 165 P 1 1 2 2 1 1
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117 167 P 1 2 1 3 1 1
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117 169 P Agerelated changes in es
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117 171 P PACAP 1,2 1,3 Ran
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117 173 P Vc Vc M
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117 175 P C β ISL1 NKX2.2
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117 177 P 1 2 3 4,5 4
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117 179 P TIRF ECM ECM 1
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117 181 P 1 1 1 1 1
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117 183 P 1 2 1 1 1 1
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117 185 P NMJ NMJ d
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117 187 P 2023 66 R
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117 189 P 1 1 1 1 1
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192 117 Marson, Lesley Masahiro,
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194 117 1OFPMI2 1OFPM
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196 117 3P042 2OFAMV2 3OEPM
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198 117 1P015 2P020
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200 117 2OHAMI1 2OHAMIII3 1P0
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202 117 S36 1P097 S95 S52
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204 117 3OEPMVII
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206 117 1P022 2P130
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117 209 117 2012 2 22
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