第117å›žæ—¥æœ¬è§£å‰–å­¦ä¼šç·ä¼šãƒ»å ¨å›½å­¦è¡“é›†ä¼š 講演プログラム・抄録集 PDF ...

84
117
S
BFI FIB/SEM
1 2 2 1
1 1 1
1
2
/
iPS
Muse PDGFRα
SEM BFI
FIB/SEM
BFI
SEM
FIB/SEM SEM
FIB BFI
3
S
1 2 1 2 1
1
2 2 1
Mesenchymal stem cell, MSC
MSC DSS
MSC
MSC
MSC
conditioned medium, MSCCM
DSS
IEC6
MALDITOFMS MSCCM
MSCCM DSS
IEC6 PI3KAkt
T MSCCM
VEGF, IL13, TIMP
MSC gut trophic factor
S
Motile and immune functions of intestinal
subepithelial myofibroblasts
Islam Md Shafiqul, Hiroshi Ozaki
Department of Veterinary Pharmacology, Graduate School of
Agriculture and Life Sciences, The university of Tokyo
Intestinal subepithelial myofibroblasts (ISMF) are a syncytium of
α-SMA-positive, mesenchymal cells, which reside subjacent to the
basement membrane of the small and large intestines. ISMFs are
considered to mediate the movement of intestinal villi, regulation of
epithelial cell proliferation and differentiation, and mucosal protection
under physiological condition. ISMFs secrete many proinflammatory
cytokines, growth factors, chemokines and other inflammatory
mediators, as well as extracellular matrix proteins. This allows ISMF
cells to act in a paracrine and autocrine fashion to mediate immune
functions under pathological conditions. Extracellular matrices, such
as collagen, fibronectins and tenascin C (TnC), secreted by ISMFs
are important in tissue remodeling and tissue repair. Our laboratory
findings have been demonstrated that TnC and α-SMA densely
expressed in DSS-induced colitis model mice particularly at the sites
of inflammation, as well as in SAMP1/Yit spontaneous ileitis model
mice. We have also identified ISMF as one of the TnC producing
cells in the intestine. In this symposium, I shall describe the recent
development of ISMF research, especially focusing TnC.
S
fibroblastlike
cells PDGF α SK3
CD34 1
ATP NO
PDGF
α CD34 PDGF α
NG2
ATP P