More documents

Recommendations

Info

74 117 S 100 Thoma Evans Danio rerio PICA S Brant Weinstein National Institutes of Health, NICHD The cranial vasculature is essential for the survival and development of the central nervous system, and is important in brain pathologies. Cranial vessels form in a reproducible and evolutionarily conserved manner, but the formation process remains unclear. We are using zebrafish to better understand the mechanisms underlying hindbrain vascular development by (i) carrying out a precise anatomical description of the formation process, (ii) investigating the molecular mechanisms guiding vascular patterning in the brain, and (iii) using genetic screens to identify new genes important for brain vessel formation. We found that the basilar artery is formed by a novel process of medial sprouting and migration of endothelial cells from a bilateral pair of veins, the primordial hindbrain channels. Subsequent second wave of dorsal sprouting from the primordial hindbrain channels give rise to angiogenic central arteries that penetrate into the hindbrain. We have also discovered that chemokine signaling is required to direct basilar artery assembly. I will report on these and other novel molecular processes involved in the assembly of hindbrain vascular networks. S Coordinated branching morphogenesis of coronary vessels and peripheral sympathetic nerves in the developing heart Yosuke Mukoyama 1,2 1 National Institutes of Health, 2 National Heart, Lung, and Blood Institute Anatomical proximity and close patterning of peripheral nerves and blood vessels suggest that there is interdependence between the two networks. The first such indication of this interplay is the responsiveness of vascular development to signals secreted by peripheral sensory nerves in the developing skin. Interestingly, we discovered a reciprocal guidance event in the patterning of peripheral sympathetic nerves in the developing heart. Our whole-mount imaging approaches revealed that sympathetic axons branch alongside large-diameter coronary veins in the surface layer of the dorsal ventricular wall prior to innervating final targets such as coronary arteries and cardiomyocytes in the deeper myocardial layer. Further genetic studies and in vitro organ culture experiments demonstrated that coronary veins serve as an intermediate template that guides distal sympathetic axon projection via local secretion of NGF by coronary vascular smooth muscle cells. Our results suggest that target organs possess unique and stereotypical patterns of innervation, mediated by tissue sub-structures, such as coronary veins in the heart, which adapt to complex organ structure and physiology. S CT CT 23 4 AI CT CT CT 3 CT
117 75 S 1 2 1 1 1 2 2 1 2 22 7 11 16 multidetector CT DSA PACS 1 5 5 8 12 4 FA2 1 2 FA CT FA 1 2 FA FA CT CT CT S CT 1,2 1 2 CTComputed Tomography CT CT CT CT CT CT CT S 2022 AIES LAN CTMRI AIES CTMRI CT OsiriX 3 CTMRI WordPowerpoint <strong>PDF</strong> PC iPad S CT 1 1 1 2 2,5 3 4 1 1 2 3 4 5 A CT 21 23 CT CT CT 21 2223 OsiriX iPod touch 23 iPad
Page 5 and 6:
2 4 5 6 8 9 10 12 12 13 1
Page 7 and 8:
117 3 1 1 1980 4 2002 200
Page 9 and 10:
117 5 100 http://yamanashiko
Page 11 and 12:
117 7
Page 13 and 14:
117 9 1117TEL: 0552541000 URL:
Page 15 and 16:
117 11 Y 1 Y12 3 26 8001930
Page 17 and 18:
117 13 8 4 PC PC PC
Page 19 and 20:
117 15 24 3 28 9151530 3 28
Page 21 and 22:
117 17
Page 23 and 24:
117 19 2 1P0
Page 25 and 26:
117 21 4008510 4437FAX 055
Page 27 and 28:
117 23 TEL0196515110 5880FAX01990
Page 29:
117
Page 32 and 33: 26 117 ::B M 15 30
Page 34 and 35: 28 S S S S 117 ex vivo
Page 36 and 37: 30 S 117 Coordinated branching mo
Page 38 and 39: 32 117 ::A M M S. 2
Page 40 and 41: 34 117 ::A M M S. S
Page 42 and 43: 36 117 S kisspeptin S
Page 44 and 45: 38 117 S S ::B M M S.
Page 46 and 47: 40 117 E L C LC ::OEPM I
Page 48 and 49: 42 117 E L C LC ::OEAM III
Page 50 and 51: 44 117 2OHAMIII2 2OHAMIII3 1
Page 52 and 53: 46 117 F L C LC ::OFPM VI 3
Page 54 and 55: 48 117 :: I 1P001 S100A
Page 56 and 57: 50 117 1P073 Makoto Naganuma Acti
Page 58 and 59: 52 117 2P018 Conserved properti
Page 60 and 61: 54 117 2P090 2P091 2P092
Page 62 and 63: 56 117 3P027 3P028 ABC 3P0
Page 64 and 65: 58 117 :: 3P102 3P103
Page 67 and 68: 117 59 100 μm 20 nm 1 μ
Page 69 and 70: 117 61 12 345
Page 71 and 72: 117 63 SM G
Page 73 and 74: 117 65 S Physiological roles of ce
Page 75 and 76: 117 67 S 1,2 1 1 2 JST S
Page 77 and 78: 117 69 S The role of autophagyrela
Page 79 and 80: 117 71 S - ATP ionom
Page 81: 117 73 S 3D 2 3D 3
Page 85 and 86: 117 77 S GSK3β gl
Page 87 and 88: 117 79 S niche DNA endos
Page 89 and 90: 117 81 S GABA GABA Cl KCC2C
Page 91 and 92: 117 83 S By means of retrograd
Page 93 and 94: 117 85 S S
Page 95 and 96: 117 87 S 1,2,3 1 2 CREST, JS
Page 97 and 98: 117 89 S C 1 1 2 1 2 1
Page 99 and 100: 117 91 S Focused Ion BeamScanning
Page 101 and 102: 117 93 S 2
Page 103 and 104: 117 95 S S
Page 105 and 106: 117 97 W WG 1,2 1 2 WG
Page 107 and 108: 117 99 OEPMI Singleneuron tracing
Page 109 and 110: 117 101 OFPMII 1 2 3 2
Page 111 and 112: 117 103 OHPM Two immunogenic passe
Page 113 and 114: 117 105 OEAMIII PHAL
Page 115 and 116: 117 107 OFAMIV 1 1 1 2
Page 117 and 118: 117 109 OGAMII BrdU Labelr
Page 119 and 120: 117 111 OHAMIII 1 2 2 2
Page 121 and 122: 117 113 ODPMI Large Maf Large
Page 123 and 124: 117 115 OEPMVII 1 1 2 2
Page 125 and 126: 117 117 OFPMVIII α
Page 127 and 128: 117 119 OHPMIV 1
Page 129 and 130: 117 121 OIPMIV 1 2 1 1
Page 131 and 132: 117 123 P SA 1 2 1 2 Glial
Page 133 and 134:
117 125 P γ 4,52 P
Page 135 and 136:
117 127 P cFos 1 2 1 1
Page 137 and 138:
117 129 P Identification of CSPG c
Page 139 and 140:
117 131 P NOS 1 2 4 4
Page 141 and 142:
117 133 P DPEP 1 2 2 1
Page 143 and 144:
117 135 P Activities of human uppe
Page 145 and 146:
117 137 P 2010 77 2
Page 147 and 148:
117 139 P Nacholapithecus kerioi
Page 149 and 150:
117 141 P kirrel 1 1 1
Page 151 and 152:
117 143 P prechordal chond
Page 153 and 154:
117 145 P FIB/SEM 1,3 1 2
Page 155 and 156:
117 147 P VIP 12 VIP
Page 157 and 158:
117 149 P Motor protein KIFA is es
Page 159 and 160:
117 151 P parvic
Page 161 and 162:
117 153 P SEM 75 mM KC
Page 163 and 164:
117 155 P mAtgAAcGFP mDFCPmCherry
Page 165 and 166:
117 157 P αMangostin 1 2
Page 167 and 168:
117 159 P 1 1 1 1 2 1
Page 169 and 170:
117 161 P planar cell polarity
Page 171 and 172:
117 163 P The metabolism of choles
Page 173 and 174:
117 165 P 1 1 2 2 1 1
Page 175 and 176:
117 167 P 1 2 1 3 1 1
Page 177 and 178:
117 169 P Agerelated changes in es
Page 179 and 180:
117 171 P PACAP 1,2 1,3 Ran
Page 181 and 182:
117 173 P Vc Vc M
Page 183 and 184:
117 175 P C β ISL1 NKX2.2
Page 185 and 186:
117 177 P 1 2 3 4,5 4
Page 187 and 188:
117 179 P TIRF ECM ECM 1
Page 189 and 190:
117 181 P 1 1 1 1 1
Page 191 and 192:
117 183 P 1 2 1 1 1 1
Page 193 and 194:
117 185 P NMJ NMJ d
Page 195 and 196:
117 187 P 2023 66 R
Page 197 and 198:
117 189 P 1 1 1 1 1
Page 199:
117
Page 202 and 203:
192 117 Marson, Lesley Masahiro,
Page 204 and 205:
194 117 1OFPMI2 1OFPM
Page 206 and 207:
196 117 3P042 2OFAMV2 3OEPM
Page 208 and 209:
198 117 1P015 2P020
Page 210 and 211:
200 117 2OHAMI1 2OHAMIII3 1P0
Page 212 and 213:
202 117 S36 1P097 S95 S52
Page 214 and 215:
204 117 3OEPMVII
Page 216 and 217:
206 117 1P022 2P130
Page 219:
117 209 117 2012 2 22
Page 227 and 228:
3D Helios NanoLab TM •3D •
show all

ç¬¬117åæ¥æ¬è§£åå­¦ä¼ç·ä¼ã»å ¨å½å­¦è¡éä¼ è¬æ¼ãã­ã°ã©ã ã»æé²é PDF ...

Create successful ePaper yourself

Delete template?

Save as template?

ç¬¬117åæ¥æ¬è§£åå¦ä¼ç·ä¼ã»å¨å½å¦è¡éä¼ è¬æ¼ããã°ã©ã ã»æé²é PDF ...