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117 161<br />
P<br />
planar cell polarity <br />
<br />
1 2<br />
1<br />
2 RI <br />
<br />
2 <br />
<br />
<br />
planar cell polarity <br />
4-5 Wistar <br />
EDTA <br />
frizzled3 Vangl2 Alexa488 Alexa555 <br />
<br />
<br />
β N <br />
Vangl2 <br />
<br />
frizzled3 <br />
<br />
planar cell polarity <br />
<br />
P<br />
<br />
Miyuki Yamamoto, Shoichi Iseki<br />
<br />
<br />
<br />
SD GCT <br />
GCT SD ID <br />
stem or progenitor cell <br />
5 K5 <br />
progenitor cell basal<br />
epithelial cell K5 <br />
K5 <br />
progenitor cell <br />
C57BL/6 K5 <br />
stem cell <br />
<br />
<br />
ID ID <br />
lumen <br />
progenitor cell<br />
<br />
P<br />
Studies on the submandibular gland of androgen receptordeficient mice<br />
Kannika Adthapanyawanich, Hiroki Nakata, Tomohiko Wakayama,<br />
Shoichi Iseki<br />
Department of Histology and Embryology, Graduate School of Medical Science,<br />
Kanazawa University<br />
In the submandibular gland SG of mice, the duct portion called granular<br />
convoluted tubule GCT is developed preferentially in the male. To clarify if<br />
the androgendependent differentiation of GCT cells is mediated by the classical<br />
androgen receptor AR, we examined SG in the C57BL/6 strain mouse deficient<br />
for AR ARKO. The ARKO mouse was generated by the Cre/loxP recombination<br />
system using the floxedAR mouse provided by Dr. Shigeaki Kato. In male ARKO,<br />
GCT was not formed in the duct system during the postnatal development,<br />
resulting in the femaletype SG at adult age 8W. No abnormality was recognized<br />
in development of the acinar system. The levels of the expression of NGF and<br />
EGF, markers of GCT cells, in SG of ARKO male were even lower than those<br />
of wildtype female. When testosterone was administered to ARKO male and<br />
wildtype female, the duct system of wildtype female was converted to the male<br />
type both morphologically and in the levels of marker gene expression, whereas<br />
that of ARKO male remained in the female type. These results confirmed that<br />
the androgendependent cell differentiation in the duct system of mouse SG is<br />
mediated by the classical AR.<br />
P<br />
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1 2 3<br />
1<br />
2 NPO <br />
3 <br />
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<br />
Neovison vison <br />
<br />
<br />
HE 3.5NHCl <br />
S800 <br />
45 V <br />
<br />
1 <br />
<br />
<br />
<br />
1 <br />
1 <br />
<br />
<br />
<br />
<br />
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P<br />
<br />
<br />
<br />
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7 <br />
<br />
7 1 <br />
deoxycholate <br />
<br />
<br />
<br />
<br />
deoxycholate <br />
<br />
STIM stromal interaction molecule<br />
SOCEstoreoperated calcium entry<br />
SOCE <br />
<br />
P<br />
A AB <br />
<br />
<br />
<br />
3 <br />
<br />
3A <br />
3AB <br />
3A 3AB <br />
SN38 <br />
<br />
3A 3AB
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