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154 117 P 1 2 1 2 P - • • EGFR EGF EGFR EGFR EGFR - - AP1 GGA EGFR AP1 GGA2 EGFR GGA1 GGA3 AP1 GGA2 EGFR D EGFR GGA2 CIMPR EGFR AP1•GGA2 EGFR EGFR P VAMP Khairani Astrid Feinisa SNARE VAMP vSNARE VAMP5 mRNA VAMP5 VAMP5 VAMP5 VAMP5 P 1 2 3 3 1 2 3 A23187: f6 μM Zymosan 5 ms/frame AQUACOSMOS 1 47 23 ms n=41 18 ms n=21 P Involvement of Rab in phagosome formation through regulating ARF activity by ACAP 1 2 1 1 2 Phagosome formation and subsequent maturation are complex sequences of events that involve actin cytoskeleton remodeling and membrane trafficking. In our livecell studies, we found that Rab35 accumulated markedly at the membrane where IgG opsonized erythrocytes IgGEs are bound. Rab35 silencing by RNA interference or the expression of GDP or GTPlocked Rab35 mutant drastically reduced the rate of phagocytosis of IgGEs. Actinmediated pseudopod extension to form phagocytic cups was disturbed by the Rab35 silencing or the expression of GDPRab35, although initial actin assembly at the IgGE binding sites was not inhibited. Furthermore, GTPRab35dependent recruitment of ACAP2, an ARF6 GAP, was shown in the phagocytic cup formation. The ARF6 activation during FcγRmediated phagocytosis was severely impaired by expressing GTP bound mutant of Rab35. Concomitantly, overexpression of ACAP2 along with GTPlocked Rab35 showed a synergistic inhibitory effect on phagocytosis. Taken together, it is likely that Rab35 regulates actindependent phagosome formation by recruiting ACAP2, which might control actin remodeling through ARF6. P AtgAmRNA HeLa /A study on AtgAmRNAknockdown HeLa cells Atg9 Atg9A 9B Atg9A HeLa Atg9AmRNA siRNA lamp1 EEA1 Atg9A
117 155 P mAtgAAcGFP mDFCPmCherry 1 1 2 1 1 2 Atg Atg9A Atg9A DFCP1 Double FYVEdomain Containing Protein 1 mAtg9A AcGFPmDFCP1mCherry mAtg9AAcGFP in vivo Atg9ADFCP1 P Histological analysis of adipose tissues in Xpg null mice Hironobu Nakane 1 , Tadahiro Shiomi 2 , Toshio Kameie 1 , Sumire Inaga 1 , Tomonori Naguro 1 1 Div.Genome Morph., Fac. Med., Tottori Univ., 2 Rad. Safety Res. Center, Natl. Inst. Radiol. Sci. Some xeroderma pigmentosum group G XPG patients exhibit skin abnormalities, growth failure, lifeshortening and neurological dysfunctions, which are also characteristic features of Cockayne syndrome CS. The XPG gene XPG encodes a structurespecific DNA endonuclease that functions in nucleotide excision repair NER. The Xpg null mice showed postnatal growth failure, ataxia and premature death. We examined pathological changes of adipose tissues corresponding to clinical manifestations in the Xpg null mice, such as cachexia, joint contractures. Xpg null mice provide a good animal model for studying the mechanisms underlying clinical symptoms of XPG/CS, CS in humans. We will discuss the function of XPG protein in the adipose tissues of the Xpg null mice. P mdx 1 1 2 1 Khairani Astrid Feinisa 1 1 1 1 1 2 mdx LC3p62 P McARH ALP McARH 7777 ALP ALP ALP 1EEA1 ALP ALP EEA1 ALP EEA1 ALP EEA1 EEA1 ALP ALP 15 ALP McARH 7777 ALP EEA1 ALP P focal adhesion, FA FA ECM ECM Cytograph, DNP• 10, 15, 30 μm FA Rho cSrc FA FA cSrc pY 418 cSrc Rho cSrc Rho ECM P lamin A/C Type lamin A/C lamin A/C ROBC26 C26 lamin A/C C26 lamin A/C Dexamethasone, IBMX, insulin C26 lamin A/C lamin A/C lamin A/C short hairpin RNA shRNA lamin A/C C26 lamin A/C
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117 89 S C 1 1 2 1 2 1
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117 97 W WG 1,2 1 2 WG
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117 99 OEPMI Singleneuron tracing
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204 117 3OEPMVII
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