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OEPMVII<br />
<br />
1 1 2 2 1<br />
1<br />
2 <br />
<br />
<br />
<br />
<br />
experimental<br />
autoimmune encephalomyelitis: EAE EAE <br />
<br />
C57BL/6 Myelin oligodendrocyte<br />
glycoprotein 3555 MOG3555 <br />
EAE <br />
<br />
<br />
<br />
<br />
EAE <br />
<br />
<br />
<br />
EAE <br />
OEPMVII<br />
RAGE<br />
<br />
<br />
<br />
Receptor for advanced glycation end productsRAGE<br />
<br />
RAGE <br />
RAGE<br />
<br />
BCCAORAGE <br />
RAGE esRAGERAGE <br />
3 BCCAO <br />
<br />
BCCAO 12 <br />
3-7 RAGE <br />
RAGE esRAGE <br />
24 7 <br />
12 <br />
<br />
RAGE <br />
<br />
<br />
OEPMVIII<br />
Fasting and highfat diet alter histone deacetylase expression in the<br />
medial hypothalamus<br />
<br />
<br />
Increasing attention is now being given to the epigenetic regulation of animal<br />
and human behaviors including the stress response and drug addiction. Histone<br />
deacetylases HDACs are involved in the epigenetic control of gene expression<br />
and alter behavior in response to a variety of environmental factors. In response<br />
to fasting and highfat diets, the expression of both orexigenic and anorexigenic<br />
neuropeptides change in the medial hypothalamus, a crucial region for feeding<br />
behavior and body weight homeostasis. However, the mechanism by which gene<br />
expression is modulated in the medial hypothalamus remains to be clarified.<br />
Here, we examined the expression of HDAC family members in the medial<br />
hypothalamus of mice in response to either fasting or a highfat diet. In response<br />
to fasting, HDAC3 and 4 expression levels increased while HDAC10 and<br />
11 levels decreased. Four weeks on a highfat diet resulted in the increased<br />
expression of HDAC5 and 8. Therefore, HDACs may be implicated in altered<br />
gene expression profiles in the medial hypothalamus under different metabolic<br />
states.<br />
OEPMVIII<br />
<br />
1 2 3 1<br />
1<br />
2 3 <br />
<br />
<br />
<br />
<br />
1 2 <br />
3 <br />
1<br />
2 <br />
PGP9.5 <br />
CGRP <br />
1/3 <br />
Aδ <br />
C <br />
1/21/3 <br />
<br />
CGRP C <br />
<br />
<br />
<br />
OEPMVIII<br />
PAM <br />
1,2 1 1<br />
1<br />
2 <br />
PAMPressure Application Measurement<br />
Randall Selitto<br />
<br />
<br />
PAM <br />
5 <br />
6 <br />
<br />
NSAIDs 10 1 2 <br />
3 <br />
NSAIDs PAM<br />
<br />
<br />
cFos <br />
<br />
OFPMVI<br />
<br />
<br />
1 Watson Eileen 2 1<br />
1<br />
2 Dept. Oral Health Sciences, University of<br />
Washington<br />
Proteaseactivated receptor PAR <br />
G 7 PAR <br />
<br />
PAR <br />
PAR RTPCR PAR2 <br />
PAR2 SLIGRLNH 2 <br />
[Ca 2+ ] i Ca 2+ [Ca 2+ ] i<br />
<br />
Ca 2+ noncapacitative calcium entry NCCE <br />
<br />
Ca 2+ NOS <br />
LNAME <br />
ADP <br />
calmodulin kinase II CAMK II <br />
calmodulin [Ca 2+ ] i <br />
PAR2 [Ca 2+ ] i <br />
NOS <br />
Calmodulin CAMK II
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