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160 117 P 1 1 1 2 1 1 2 / +/+, +/,/+,/ 4 1 1 30 10 CL TC +/+ /+ / 2 P 1 2 3 4 1 2 3 4 Softex 90 P Klotho 1 1 1 2,3 4 1 1 2 3 4 klotho klotho/ 5 klotho/ von Kossa, van Geison I MGPαsmooth muscle actinα SMAALPENPP1 TEM MGP klotho/ α SMA MGP I ALP ENPP1 TEM MGP klotho/ P FAMA 1 1 1 1 1 2 2 1 1 2 FAM20A is a member of family with sequence similarity 20 FAM20 which has three members FAM20A, FAM20B and FAM20C in mammals. We have reported a transgenic Tg mouse line the lineage 230 exhibiting growth disorder associated with a 58kb fragment deletion in chromosome 11E1 that encompasses part of the FAM20A gene. Recently, some studies have reported that patients with amelogenesis imperfecta caused by FAM20A mutation display several dental phenotypes including hypoplastic enamel, failure of tooth development and gingival hyperplasia. In the present study, we aimed to clarify how the loss of FAM20A protein influenced the development of mouse dental tissues. We have observed delayed tooth eruption in the homozygous mice of the lineage 230. Immunohistochemistry indicated that FAM20a protein was expressed in osteoid tissue and tooth germ of normal mice of the lineage 230, but was not expressed in homozygous mice of the lineage 230. The light microscopy demonstrated hypoplastic enamel and gingival hyperplasia in the homozygous mice of the lineage 230. In conclusion, this study revealed that the FAM20A protein played a critical role in enamel biomineralization. P GABA GABA 1 2 2 2 3 3 4 1 1 2 3 4 GABA GAD GABA GABA GABA GABA OUMS27 RTPCR GABA GABA RTPCR GABA GABAA α2α5β1 GABAB GABAB1 GABAB2 mRNA GABAB2 mRNA GABAB GABAB P Polypterus senegalus Oxydoras niger 1 1 1 1 2 1 1 2 5 Polypterus senegalus Oxydoras niger SGCs SGCs SGCs 50 μm 100 μm SGCs SGCs SGCs SGCs
117 161 P planar cell polarity 1 2 1 2 RI 2 planar cell polarity 4-5 Wistar EDTA frizzled3 Vangl2 Alexa488 Alexa555 β N Vangl2 frizzled3 planar cell polarity P Miyuki Yamamoto, Shoichi Iseki SD GCT GCT SD ID stem or progenitor cell 5 K5 progenitor cell basal epithelial cell K5 K5 progenitor cell C57BL/6 K5 stem cell ID ID lumen progenitor cell P Studies on the submandibular gland of androgen receptordeficient mice Kannika Adthapanyawanich, Hiroki Nakata, Tomohiko Wakayama, Shoichi Iseki Department of Histology and Embryology, Graduate School of Medical Science, Kanazawa University In the submandibular gland SG of mice, the duct portion called granular convoluted tubule GCT is developed preferentially in the male. To clarify if the androgendependent differentiation of GCT cells is mediated by the classical androgen receptor AR, we examined SG in the C57BL/6 strain mouse deficient for AR ARKO. The ARKO mouse was generated by the Cre/loxP recombination system using the floxedAR mouse provided by Dr. Shigeaki Kato. In male ARKO, GCT was not formed in the duct system during the postnatal development, resulting in the femaletype SG at adult age 8W. No abnormality was recognized in development of the acinar system. The levels of the expression of NGF and EGF, markers of GCT cells, in SG of ARKO male were even lower than those of wildtype female. When testosterone was administered to ARKO male and wildtype female, the duct system of wildtype female was converted to the male type both morphologically and in the levels of marker gene expression, whereas that of ARKO male remained in the female type. These results confirmed that the androgendependent cell differentiation in the duct system of mouse SG is mediated by the classical AR. P 1 2 3 1 2 NPO 3 Neovison vison HE 3.5NHCl S800 45 V 1 1 1 P 7 7 1 deoxycholate deoxycholate STIM stromal interaction molecule SOCEstoreoperated calcium entry SOCE P A AB 3 3A 3AB 3A 3AB SN38 3A 3AB
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117 9 1117TEL: 0552541000 URL:
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44 117 2OHAMIII2 2OHAMIII3 1
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50 117 1P073 Makoto Naganuma Acti
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52 117 2P018 Conserved properti
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54 117 2P090 2P091 2P092
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56 117 3P027 3P028 ABC 3P0
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58 117 :: 3P102 3P103
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117 59 100 μm 20 nm 1 μ
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117 61 12 345
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117 63 SM G
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117 65 S Physiological roles of ce
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117 67 S 1,2 1 1 2 JST S
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117 69 S The role of autophagyrela
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117 75 S 1 2 1 1 1
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117 81 S GABA GABA Cl KCC2C
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117 83 S By means of retrograd
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117 87 S 1,2,3 1 2 CREST, JS
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117 89 S C 1 1 2 1 2 1
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117 91 S Focused Ion BeamScanning
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117 97 W WG 1,2 1 2 WG
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117 99 OEPMI Singleneuron tracing
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117 101 OFPMII 1 2 3 2
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117 103 OHPM Two immunogenic passe
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117 105 OEAMIII PHAL
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117 107 OFAMIV 1 1 1 2
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117 209 117 2012 2 22
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