第117å›žæ—¥æœ¬è§£å‰–å­¦ä¼šç·ä¼šãƒ»å ¨å›½å­¦è¡“é›†ä¼š 講演プログラム・抄録集 PDF ...

117 109
OGAMII
BrdU
Labelretaining cells
LRCs
ICR 3 BrdU 5
1 2 EDTA Nestin
OPN BrdU TUNEL in situ
Dsp
1 TUNEL
LRCs 35
Nestin LRCs
Nestin 7
OPN
DspmRNA
LRCs
OPN
OGAMIII
Cx NFATc
1 2 1 3
1
2 3
Cx45
Cx45
Cx45
Cx45
Cx45
Cx45
Cx45
NFATc
NFATc VEGF
Cx45
NFATc
OGAMIII
FGF
1 2
1
2
GDNF
FGF
1213
FGFcanonical, 15 FGF 7
FGF 3
GDNF Ret, GFRα1
FGF5, FGF9,
FGF17, FGF18, FGF22 FGF9
10 FGF9
Ret, GFRα1 GDNF
FGF9 FGF9
FGF
FGF9
FGF9
OGAMIII
An attempt to identify novel ciliary genes by database comparison
Cilia and flagella are hairlike organelles that project from the cell surface and
have been implicated in a diversity of cell functions. Although a number of
putative ciliary genes have been identified by several global analyses, little is
known about the functions of these genes. To gain a better understanding of ciliary
biology, we selected ciliary candidate genes from comprehensive ciliary protein
data sets, named ciliome, and analyzed their antisenseknockdown phenotypes
in medaka embryos. To maximize quality hits, we selected genes expressing
in ciliary organs based on the zebrafish expression database. Comparing the
expression among 5 ciliary organs, we found that 18 genes are commonly
expressed in more than 4 organs out of the above 5. Comparing these genes with
ciliome database, 5 out of the 18 genes were recorded in ciliome database. We
therefore preliminary examined the medaka antisenseknockdown phenotypes of
2 of the 5 genes. One revealed hydrocephalous and the other showed cystic kidney
phenotype: both of which are ciliadefective phenotypes. This data suggests that
our strategy is a promising approach to understanding various roles for ciliome
proteins.
OHAMI
1 1 2 1
1
2
58
Rmax
10 mm
27
OHAMI
On the phylogeny of the zygomatic arch, and its relationships among
foramina and the bony wall of the orbit
1,3 1 2 2 3
3 4 4 4 4
1
Kanagawa Dental College, 2 Edogawa Hospital, 3 Dept. Radiology, Yokohama City
Univ. Sch. Med., 4 Dept. Neurosurgery, Yokohama City Univ. Sch. Med.
The existence of the arcus zygomaticus is a characteristic of mammalian skulls.
The arches provide surface for the masseter muscle to attach, and the canalis
zygomaticus stores the passage of the zygomatic nerve. Romer & Parsons
surmised that the arches are a last remnant of the former lateral walls of the
reptilian skull. Only Simiiformes Catarrhini and Platyrrhini has the perfect bony
orbital wall, whereas the Prosimii, Perissodactyla, and Artiodactyla lost the rear
wall and floorbord of the bony orbit, and the Carnivora lost the lateral posterior
bony wall of the orbit. However Hystricomorpha has another pair of arches on
the lateral walls of the greatly enlarged infraorbital foramen. This structure seems
to us a new frontal and rear expansion and reinforcement of the zygomatic arch.
In the Simiiformes, the Fossa temporalis has a relatively large volume so that the
brain case has become a high structure. Therefore it was not necessary for the
zygomatic arch to enlarge in front and behind.