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164 117 P α β 2 α 18 β 8 24 3 α β Zeiss LSM710 β18 β5 β5 2 αv P 66 CD41 ICR CD41 12 22.96.6/mm 3 14 38.410.0/mm 3 16 0 21.710.0/mm 3 6 3.62.0/mm 3 20 2 P The role of hematopoietic factors and Wnt signaling during tooth development Masataka Sunohara, Iwao Sato Department of Anatomy, School of Life Dentistry at Tokyo, The Nippon Dental University, Tokyo, Japan Purpose:It has been reported that Wnt signaling pathway is involved in the early tooth development and regulates haematopoietic stem cells HSCs. However the role of hematopoietic factors during tooth development remain unclear. Here we examine the role of hematopoietic factors and Wnt signaling during tooth development in mice. Methods:We performed in situ hybridization and immunohistochemically stained serial sections of dental tissues with antibodies against hematopoietic factors and Wnt. Results:We observed that hematopoietic factors were detected at the some stages of tooth development and Wnt was localized in mesenchymal layers at the late stage of tooth development. Conclusions:These data suggest that hematopoietic factors and Wnt were involved in tooth germ development in mice. *This study was was supported by a GrantinAid for Scientific Research C No.22592052. P 1 2 2 2 1 2 Al V 64 Ti6Al4V PMN PMN NADPH oxidase O2 H2O2 PMN OPZ OPZ H2O2 Ce V PMN Al PMN PMN Ti6Al4V PMN H2O2 PMN Ti6Al4V PMN 3710 Ce H2O2 3720 GA PMN PMN H2O2 P podoplanin C57BL/6 4% podoplaninLYVE1 in situ hybridization CCL21 5 HE 3 podoplanin LYVE1 podoplnanin 3 5 CCL21 in situ hybridization CCL21 podoplanin podoplanin P VEGFA VEGFA PDGFRβ NG2 NG2 PDGFRβ NG2
117 165 P 1 1 2 2 1 1 2 DDS SCID 1 CDDP 3 CDDP 1 P 1 1 2 3 3 1 1 2 3 5 8 10 1 1 4-7 2 3-7 3 3-7 1 7-12 2 6-14 3 5-11 P 64 128 124 97 94 73 46 36 27 21% 1 1% IVI 6 IIV N I II IIIIV III V VI P 1 1 2 1 1 1 1 1 2 Wistar SDSPAGE 50 nm SDSPAGE P Nkx. 1 1 1 1 2 1 1 2 Nkx2.5 GATA4 TBX5 Nkx2.5 KONkx2.5+/− Nkx2.5+/− 1020 C57BL/6JNkx2.5+/− 4%PFA Nkx2.5+/− P Morphological analysis of effects with arachidonic acid in smooth muscle cells Hideyuki Tanaka 1 , Haruo Hagiwara 2 , Shinnichi Mitui 1 1 Labo.Sci, Gunma Univ. Grad. Sch. Health Sci., 2 Anatomy, Teikyo Univ. Sch. Med. We previously reported that arachidonic acid enhanced the ATPase activity of smooth muscle myosin of which 20 kDa myosin light chain MLC20 was phosphorylated to leave no room for the additional phosphorylation. We report here that configuration of smooth muscle myosin changes to activated form with arachidonic acid from inactiveted form under unphosphorytated condition. And, selfaseembly of each myosins was enhanced in vitro. Such a direct effect of arahidonic acid was confirmed by inducing superprecipitation, an invitro contraction, and contraction of TritonX skinned fiber of smooth muscle under conditions that the phosphorylation of MLC20 didi not proceed. An electron microscopic observation of superprecipitation, and of skinned fibers with arachidonic acid indicated an enhanced association of actin fibers with myosin filaments.
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117 69 S The role of autophagyrela
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117 97 W WG 1,2 1 2 WG
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117 99 OEPMI Singleneuron tracing
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117 111 OHAMIII 1 2 2 2
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