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Polio Vaccines<br />

<strong>and</strong> the Origin<br />

<strong>of</strong> AIDS;<br />

The Career <strong>of</strong><br />

a Threatening<br />

Idea<br />

Brian Martin, Ph.D.<br />

When a virus from one species is able to survive in a different species, at<br />

first it is <strong>of</strong>ten quite virulent in the new species. For example, the myxoma<br />

virus causes little problem in the South American forest rabbit, its<br />

longst<strong>and</strong>ing host, but it was devastating when introduced among<br />

European rabbits in Australia. As the virus rampages through the new<br />

species, susceptible individuals are killed, whereas the resistant ones survive<br />

<strong>and</strong> reproduce, <strong>and</strong> eventually virulence declines, as in the case <strong>of</strong><br />

myxomatosis in Australia. 1<br />

Thus, when a new viral disease springs unannounced on humans, one<br />

possible suspect is animal viruses. In the case <strong>of</strong> AIDS, this soon became<br />

the most favored explanation among scientists. In 1983, Luc Montagnier<br />

<strong>and</strong> his colleagues reported isolation <strong>of</strong> a virus, later called human immunodeficiency<br />

virus or HIV, linked to AIDS. Two years later, a type <strong>of</strong><br />

virus very similar to HIV was found in African monkeys. It was called<br />

simian immunodeficiency virus or SIV. Many SIVs cause no obvious disease<br />

in their host species, though they can be virulent if transmitted to a<br />

different, unaffected monkey species. The obvious explanation for AIDS<br />

was that SIV somehow was transmitted to humans, where it became or<br />

evolved into HIV.<br />

The next question was how the SIV might have been transmitted from<br />

simians to humans. Before looking at the possible explanations, it is worth<br />

mentioning some <strong>other</strong> evidence. First, there are two major types <strong>of</strong> HIV,<br />

called HIV-1 <strong>and</strong> HIV-2. HIV-1 is the type found throughout most <strong>of</strong> the<br />

world; HIV-2 is found mostly in western Africa.<br />

Brian Martin is a pr<strong>of</strong>essor at the University <strong>of</strong> Wollongong, NSW, Australia.<br />

73

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