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OVERCOMING RESISTANCE TO ANTI-EGFR THERAPY IN COLORECTAL CANCER<br />

combination in patients (pts) with BRAF V600E mutated colorectal<br />

cancer (CRC). J Clin Oncol. 2014;32:5s (suppl; abstr 3515).<br />

19. Tabernero J, van Geel R, Bendell JC, et al. Phase I study of the selective<br />

BRAFV600 inhibitor encorafenib (LGX818) combined with cetuximab<br />

and with or without the a -specifıc PI3K inhibitor alpelisib (BYL719) in<br />

patients with advanced BRAF mutant colorectal cancer. Eur J Cancer.<br />

2014;50 (suppl 6; abstr 11LBA).<br />

20. Laurent-Puig P, Cayre A, Manceau G, et al. Analysis of PTEN, BRAF,<br />

and EGFR status in determining benefıt from cetuximab therapy in<br />

wild-type KRAS metastatic colon cancer. J Clin Oncol. 2009;27:5924-<br />

5930.<br />

21. Perrone F, Lampis A, Orsenigo M, et al. PI3KCA/PTEN deregulation<br />

contributes to impaired responses to cetuximab in metastatic colorectal<br />

cancer patients. Ann Oncol. 2009;20:84-90.<br />

22. Tian S, Simon I, Moreno V, et al. A combined oncogenic pathway signature<br />

of BRAF, KRAS and PI3KCA mutation improves colorectal cancer<br />

classifıcation and cetuximab treatment prediction. Gut. 2013;62:<br />

540-549.<br />

23. Valtorta E, Misale S, Sartore-Bianchi A, et al. KRAS gene amplifıcation<br />

in colorectal cancer and impact on response to EGFR-targeted therapy.<br />

Int J Cancer. 2013;133:1259-1265.<br />

24. Yonesaka K, Zejnullahu K, Okamoto I, et al. Activation of ERBB2 signaling<br />

causes resistance to the EGFR-directed therapeutic antibody cetuximab.<br />

Sci Transl Med. 2011;3:99ra86.<br />

25. Bertotti A, Migliardi G, Galimi F, et al. A molecularly annotated platform<br />

of patient-derived xenografts (xenopatients) identifıes HER2 as an<br />

effective therapeutic target in cetuximab-resistant colorectal cancer.<br />

Cancer Discov. 2011;1:508-523.<br />

26. Bardelli A, Corso S, Bertotti A, et al. Amplifıcation of the MET receptor<br />

drives resistance to anti-EGFR therapies in colorectal cancer. Cancer<br />

Discov. 2013;3:658-673.<br />

27. Huang S, Li C, Armstrong EA, et al. Dual targeting of EGFR and HER3<br />

with MEHD7945A overcomes acquired resistance to EGFR inhibitors<br />

and radiation. Cancer Res. 2013;73:824-833.<br />

28. Kawakami H, Okamoto I, Yonesaka K, et al. The anti-HER3 antibody<br />

patritumab abrogates cetuximab resistance mediated by heregulin in<br />

colorectal cancer cells. Oncotarget. 2014;5:11847-11856.<br />

29. Cushman S, Jiang C, Hatch A, et al. Gene expression markers of effıcacy<br />

and resistance to cetuximab treatment in metastatic colorectal<br />

cancer: results from CALGB 80203 (Alliance). Clin Cancer Res. Epub<br />

2014 Dec 17.<br />

30. Liska D, Chen CT, Bachleitner-Hofmann T, et al. HGF rescues colorectal<br />

cancer cells from EGFR inhibition via MET activation. Clin Cancer<br />

Res. 2011;17:472-482.<br />

31. Luraghi P, Reato G, Cipriano E, et al. MET signaling in colon cancer<br />

stem-like cells blunts the therapeutic response to EGFR inhibitors. Cancer<br />

Res. 2014;74:1857-1869.<br />

32. Vakiani E, Janakiraman M, Shen R, et al. Comparative genomic analysis<br />

of primary versus metastatic colorectal carcinomas. J Clin Oncol. 2012;<br />

30:2956-2962.<br />

33. Siu LL, Shapiro JD, Jonker DJ, et al. Phase III randomized, placebocontrolled<br />

study of cetuximab plus brivanib alaninate versus cetuximab<br />

plus placebo in patients with metastatic, chemotherapy-refractory,<br />

wild-type K-RAS colorectal carcinoma: the NCIC Clinical Trials Group<br />

and AGITG CO.20 Trial. J Clin Oncol. 2013;31:2477-2484.<br />

34. Tol J, Koopman M, Cats A, et al. Chemotherapy, bevacizumab, and cetuximab<br />

in metastatic colorectal cancer. N Engl J Med. 2009;360:563-<br />

572.<br />

35. Hecht JR, Mitchell E, Chidiac T, et al. A randomized phase IIIB trial of<br />

chemotherapy, bevacizumab, and panitumumab compared with chemotherapy<br />

and bevacizumab alone for metastatic colorectal cancer.<br />

J Clin Oncol. 2009;27:672-680.<br />

36. Weickhardt AJ, Price TJ, Chong G, et al. Dual targeting of the epidermal<br />

growth factor receptor using the combination of cetuximab and erlotinib:<br />

preclinical evaluation and results of the phase II DUX study in<br />

chemotherapy-refractory, advanced colorectal cancer. J Clin Oncol.<br />

2012;30:1505-1512.<br />

37. Van Cutsem E, Eng C, Nowara E, et al. Randomized phase Ib/II trial of<br />

rilotumumab or ganitumab with panitumumab versus panitumumab<br />

alone in patients with wild-type KRAS metastatic colorectal cancer. Clin<br />

Cancer Res. 2014;20:4240-4250.<br />

38. Tamayo ME, Cornelio GH, Bautista JB, et al. Safety and effıcacy of Imprime<br />

PGG plus cetuximab with irinotecan and without irinotecan in<br />

patients with advanced colorectal cancer (CRC): a phase 1b/2 study with<br />

KRAS subpopulation analysis. Ann Oncol. 2010;21 (suppl 6; abstr<br />

PD0009).<br />

39. Perez EA, Thompson EA, Ballman KV, et al. Genomic analysis reveals<br />

that immune function genes are strongly linked to clinical outcome in<br />

the North Central Cancer Treatment Group N9831 adjuvant trastuzumab<br />

trial. J Clin Oncol. Epub 2015 Jan 20.<br />

40. Misale S, Yaeger R, Hobor S, et al. Emergence of KRAS mutations and<br />

acquired resistance to anti-EGFR therapy in colorectal cancer. Nature.<br />

2012;486:532-536.<br />

41. Bettegowda C, Sausen M, Leary RJ, et al. Detection of circulating tumor<br />

DNA in early- and late-stage human malignancies. Sci Transl Med.<br />

2014;6:224ra24.<br />

42. Arena S, Bellosillo B, Siravegna G, et al. Emergence of multiple EGFR<br />

extracellular mutations during cetuximab treatment in colorectal cancer.<br />

Clin Cancer Res. Epub 2015 Jan 27.<br />

43. Diaz LA Jr., Williams RT, Wu J, et al. The molecular evolution of acquired<br />

resistance to targeted EGFR blockade in colorectal cancers. Nature.<br />

2012;486:537-540.<br />

44. Montagut C, Bellosillo B, Gonzalez I, et al. Evolution of heterogeneous<br />

mechanisms of acquired resistance to cetuximab-based therapy in colorectal<br />

cancer. J Clin Oncol. 2014;32:5s (suppl; abstr 3526).<br />

45. Troiani T, Martinelli E, Napolitano S, et al. Increased TGF-alpha as a<br />

mechanism of acquired resistance to the anti-EGFR inhibitor cetuximab<br />

through EGFR-MET interaction and activation of MET signaling<br />

in colon cancer cells. Clin Cancer Res. 2013;19:6751-6765.<br />

46. Montagut C, Dalmases A, Bellosillo B, et al. Identifıcation of a mutation<br />

in the extracellular domain of the epidermal growth factor receptor conferring<br />

cetuximab resistance in colorectal cancer. Nat Med. 2012;18:<br />

221-223.<br />

47. Price TJ, Newhall J, Peeters M, et al. Prevalence and outcomes of patients<br />

(pts) with EGFR S492R ectodomain mutations in ASPECCT: Panitumumab<br />

(pmab) vs. cetuximab (cmab) in pts with chemorefractory<br />

wild-type KRAS exon 2 metastatic colorectal cancer (mCRC). J Clin Oncol.<br />

2015;33 (suppl 3; abstr 740).<br />

48. Iida M, Brand TM, Starr MM, et al. Sym004, a novel EGFR antibody<br />

mixture, can overcome acquired resistance to cetuximab. Neoplasia.<br />

2013;15:1196-1206.<br />

49. Hobor S, Van Emburgh BO, Crowley E, et al. TGF alpha and amphiregulin<br />

paracrine network promotes resistance to EGFR blockade in<br />

colorectal cancer cells. Clin Cancer Res. 2014;20:6429-6438.<br />

50. Wadlow RC, Hezel AF, Abrams TA, et al. Panitumumab in patients with<br />

KRAS wild-type colorectal cancer after progression on cetuximab. Oncologist.<br />

2012;17:14.<br />

51. Saif MW, Kaley K, Chu E, et al. Safety and effıcacy of panitumumab<br />

therapy after progression with cetuximab: experience at two institutions.<br />

Clin Colorectal Cancer. 2010;9:315-318.<br />

52. Paz-Ares LG, Gomez-Roca C, Delord JP, et al. Phase I pharmacokinetic<br />

and pharmacodynamic dose-escalation study of RG7160 (GA201), the<br />

fırst glycoengineered monoclonal antibody against the epidermal growth<br />

asco.org/edbook | 2015 ASCO EDUCATIONAL BOOK<br />

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