31.05.2015 Views

NcXHF

NcXHF

NcXHF

SHOW MORE
SHOW LESS

You also want an ePaper? Increase the reach of your titles

YUMPU automatically turns print PDFs into web optimized ePapers that Google loves.

SQUAMOUS, SMALL CELL, AND RARE LUNG CANCERS<br />

tumor activities alone/in combination with gemcitabine. Invest New<br />

Drugs. 2014;32:825-837.<br />

30. Fry DW, Harvey PJ, Keller PR, et al. Specifıc inhibition of cyclindependent<br />

kinase 4/6 by PD 0332991 and associated antitumor activity<br />

in human tumor xenografts. Mol Cancer Ther. 2004;3:1427-1438.<br />

31. George S, Kasimis BS, Cogswell J, et al. Phase I study of flavopiridol in<br />

combination with Paclitaxel and Carboplatin in patients with nonsmall-cell<br />

lung cancer. Clin Lung Cancer. 2008;9:160-165.<br />

32. Carmeliet P. VEGF as a key mediator of angiogenesis in cancer.<br />

Oncology. 2005;69:4-10.<br />

33. Johnson DH, Fehrenbacher L, Novotny WF, et al. Randomized phase<br />

II trial comparing bevacizumab plus carboplatin and paclitaxel with<br />

carboplatin and paclitaxel alone in previously untreated locally advanced<br />

or metastatic non-small-cell lung cancer. J Clin Oncol. 2004;22:<br />

2184-2191.<br />

34. Hainsworth JD, Fang L, Huang JE, et al. BRIDGE: an open-label phase<br />

II trial evaluating the safety of bevacizumab carboplatin/paclitaxel<br />

as fırst-line treatment for patients with advanced, previously untreated,<br />

squamous non-small cell lung cancer. J Thorac Oncol. 2011;6:<br />

109-114.<br />

35. Hellmann MD, Chaft JE, Rusch V, et al. Risk of hemoptysis in patients<br />

with resected squamous cell and other high-risk lung cancers treated<br />

with adjuvant bevacizumab. Cancer Chemother Pharmacol. 2013;72:<br />

453-461.<br />

36. Garon EB, Ciuleanu TE, Arrieta O, et al. Ramucirumab plus docetaxel<br />

versus placebo plus docetaxel for second-line treatment of stage IV<br />

non-small-cell lung cancer after disease progression on platinumbased<br />

therapy (REVEL): a multicentre, double-blind, randomised<br />

phase 3 trial. Lancet. 2014;384:665-673.<br />

37. Paez JG, Jänne PA, Lee JC, et al. EGFR mutations in lung cancer: correlation<br />

with clinical response to gefıtinib therapy. Science. 2004;304:<br />

1497-1500.<br />

38. Pao W, Miller V, Zakowski M, et al. EGF receptor gene mutations are<br />

common in lung cancers from “never smokers” and are associated with<br />

sensitivity of tumors to gefıtinib and erlotinib. Proc Natl Acad Sci U S<br />

A. 2004;101:13306-13311.<br />

39. Cappuzzo F, Hirsch FR, Rossi E, et al. Epidermal growth factor receptor<br />

gene and protein and gefıtinib sensitivity in non-small-cell lung<br />

cancer. J Natl Cancer Inst. 2005;97:643-655.<br />

40. Pirker R, Pereira JR, Szczesna A, et al. Cetuximab plus chemotherapy<br />

in patients with advanced non-small-cell lung cancer (FLEX): an openlabel<br />

randomised phase III trial. Lancet. 2009;373:1525-1531.<br />

41. Pirker R, Pereira JR, von Pawel J, et al. EGFR expression as a predictor<br />

of survival for fırst-line chemotherapy plus cetuximab in patients with<br />

advanced non-small-cell lung cancer: analysis of data from the phase 3<br />

FLEX study. Lancet Oncol. 2012;13:33-42.<br />

42. Thatcher N, Hirsch F, Szczesna A, et al. A randomized, multicenter,<br />

open-label, phase III study of gemcitabine-cisplatin (GC) chemotherapy<br />

plus necitumumab (IMC-11F8/LY3012211) versus GC<br />

alone in the fırst-line treatment of patients (pts) with stage IV squamous<br />

non-small cell lung cancer (sq-NSCLC). J Clin Oncol. 2014;<br />

32:5s (suppl; abstr 8008).<br />

43. Postow MA, Callahan MK, Wolchok JD. Immune Checkpoint Blockade<br />

in Cancer Therapy. J Clin Oncol. Epub 2015 Jan 20.<br />

44. Rizvi N, Garon E, Patnaik A, et al. Safety and clinical activity of MK-<br />

3475 as initial therapy in patients with advanced non-small cell lung<br />

cancer (NSCLC). J Clin Oncol. 2014;32:5s (suppl; abstr 8007).<br />

45. Gettinger S, Shepherd F, Antonia S, et al. First-line nivolumab (anti-<br />

PD-1; BMS-936558, ONO-4538) monotherapy in advanced NSCLC:<br />

safety, effıcacy, and correlation of outcomes with PD-L1 status. J Clin<br />

Oncol. 2014;32:5s (suppl; abstr 8024).<br />

46. Brahmer J, Rizvi N, Lutzky J, et al. Clinical activity and biomarkers of<br />

MEDI4736, an anti-PD-L1 antibody, in patients with NSCLC. J Clin<br />

Oncol. 2014;32:5s (suppl; abstr 8021).<br />

47. National Lung Screening Trial Research Team, Aberle DR, Adams<br />

AM, et al. Reduced lung-cancer mortality with low-dose computed tomographic<br />

screening. N Engl J Med. 2011;365:395-409.<br />

48. Babakoohi S, Fu P, Yang M, et al. Combined SCLC clinical and pathologic<br />

characteristics. Clin Lung Cancer. 2013;14:113-119.<br />

49. Turrisi AT 3rd, Kim K, Blum R, et al. Twice-daily compared with oncedaily<br />

thoracic radiotherapy in limited small-cell lung cancer treated<br />

concurrently with cisplatin and etoposide. N Engl J Med. 1999;340:265-<br />

271.<br />

50. Murray N, Coy P, Pater JL, et al. Importance of timing for thoracic<br />

irradiation in the combined modality treatment of limited-stage smallcell<br />

lung cancer. The National Cancer Institute of Canada Clinical Trials<br />

Group. J Clin Oncol. 1993;11:336-344.<br />

51. Jeremic B, Shibamoto Y, Acimovic L, et al. Initial versus delayed accelerated<br />

hyperfractionated radiation therapy and concurrent chemotherapy<br />

in limited small-cell lung cancer: a randomized study. J Clin<br />

Oncol. 1997;15:893-900.<br />

52. Aupérin A, Arriagada R, Pignon JP, et al. Prophylactic cranial irradiation<br />

for patients with small-cell lung cancer in complete remission.<br />

Prophylactic Cranial Irradiation Overview Collaborative Group.<br />

N Engl J Med. 1999;341:476-484.<br />

53. Slotman B, Faivre-Finn C, Kramer G, et al. Prophylactic cranial irradiation<br />

in extensive small-cell lung cancer. N Engl J Med. 2007;357:<br />

664-672.<br />

54. Seto T, Takahashi T, Yamanaka T, et al. Prophylactic cranial irradiation<br />

(PCI) has a detrimental effect on the overall survival (OS) of patients<br />

(pts) with extensive disease small cell lung cancer (ED-SCLC):<br />

results of a Japanese randomized phase III trial. J Clin Oncol. 2014;<br />

32:5s (suppl; abstr 7503).<br />

55. Slotman BJ, van Tinteren H, Praag JO, et al. Use of thoracic radiotherapy<br />

for extensive stage small-cell lung cancer: a phase 3 randomised<br />

controlled trial. Lancet. 2015;385:36-42.<br />

56. Peifer M, Fernández-Cuesta L, Sos ML, et al. Integrative genome analyses<br />

identify key somatic driver mutations of small-cell lung cancer.<br />

Nat Genet. 2012;44:1104-1110.<br />

57. Rudin CM, Durinck S, Stawiski EW, et al. Comprehensive genomic<br />

analysis identifıes SOX2 as a frequently amplifıed gene in small-cell<br />

lung cancer. Nat Genet. 2012;44:1111-1116.<br />

58. Hodgkinson CL, Morrow CJ, Li Y, et al. Tumorigenicity and genetic<br />

profıling of circulating tumor cells in small-cell lung cancer. Nat Med.<br />

2014;20:897-903.<br />

59. Han JY, Lee YS, Kim BC, et al. Whole-genome analysis of a patient with<br />

early-stage small-cell lung cancer. Pharmacogenomics J. 2014;14:503-<br />

508.<br />

60. Wildey G, Chen Y, Lent I, et al. Pharmacogenomic approach to identify<br />

drug sensitivity in small-cell lung cancer. PLoS One. 2014;9:<br />

e106784.<br />

61. Sos ML, Dietlein F, Peifer M, et al. A framework for identifıcation of<br />

actionable cancer genome dependencies in small cell lung cancer. Proc<br />

Natl Acad SciUSA.2012;109:17034-17039.<br />

62. Christensen CL, Kwiatkowski N, Abraham BJ, et al. Targeting transcriptional<br />

addictions in small cell lung cancer with a covalent CDK7<br />

inhibitor. Cancer Cell. 2014;26:909-922.<br />

63. Dabir S, Babakoohi S, Kluge A, et al. RET mutation and expression in<br />

small-cell lung cancer. J Thorac Oncol. 2014;9:1316-1323.<br />

64. Umemura S, Mimaki S, Makinoshima H, et al. Therapeutic priority of<br />

the PI3K/AKT/mTOR pathway in small cell lung cancers as revealed<br />

by a comprehensive genomic analysis. J Thorac Oncol. 2014;9:1324-<br />

1331.<br />

65. Owonikoko TK, Zhang G, Deng X, et al. Poly (ADP) ribose polymerase<br />

asco.org/edbook | 2015 ASCO EDUCATIONAL BOOK 159

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!