31.05.2015 Views

NcXHF

NcXHF

NcXHF

SHOW MORE
SHOW LESS

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

NOWAKOWSKI AND CZUCZMAN<br />

15. Aragon-Ching JB, Li H, Gardner ER, et al. Thalidomide analogues as<br />

anticancer drugs. Recent Pat Anticancer Drug Discov. 2007;2:167-174.<br />

16. Hernandez-Ilizaliturri FJ, Reddy N, Holkova B, et al. Immunomodulatory<br />

drug CC-5013 or CC-4047 and rituximab enhance antitumor activity<br />

in a severe combined immunodefıcient mouse lymphoma model.<br />

Clin Cancer Res. 2005;11:5984-5992.<br />

17. Thieblemont C, Delfau-Larue MH, Coiffıer B. Lenalidomide in diffuse<br />

large B-cell lymphoma. Adv Hematol. Epub 2012 Nov 20.<br />

18. Wu L, Adams M, Carter T, et al. Lenalidomide enhances natural killer<br />

cell and monocyte-mediated antibody-dependent cellular cytotoxicity<br />

of rituximab-treated CD20 tumor cells. Clin Cancer Res. 2008;14:<br />

4650-4657.<br />

19. Witzig TE, Vose JM, Zinzani PL, et al. An international phase II trial of<br />

single-agent lenalidomide for relapsed or refractory aggressive B-cell<br />

non-Hodgkin’s lymphoma. Ann Oncol. 2011;22:1622-1627.<br />

20. Vose JM, Habermann TM, Czuczman MS, et al. Single-agent lenalidomide<br />

is active in patients with relapsed or refractory aggressive non-<br />

Hodgkin lymphoma who received prior stem cell transplantation. Br J<br />

Haematol. 2013;162:639-647.<br />

21. Wilcox RA, Ristow K, Habermann TM, et al. The absolute monocyte<br />

and lymphocyte prognostic score predicts survival and identifıes highrisk<br />

patients in diffuse large-B-cell lymphoma. Leukemia. 2011;25:1502-<br />

1509.<br />

22. Choi MY, Kipps TJ. Inhibitors of B-cell receptor signaling for patients<br />

with B-cell malignancies. Cancer J. 2012;18:404-410.<br />

23. Wilson WH, Gerecitano JF, Goy A, et al. The Bruton’s tyrosine kinase<br />

(BTK) inhibitor, ibrutinib (PCI-32765), has preferential activity in the<br />

ABC subtype of relapsed/refractory de novo diffuse large B-cell lymphoma<br />

(DLBCL): interim results of a multicenter, open-label, phase 2<br />

study. Blood. 2012;120 (suppl; abstr 686).<br />

24. Friedberg JW, Sharman J, Sweetenham J, et al. Inhibition of Syk with<br />

fostamatinib disodium has signifıcant clinical activity in non-Hodgkin<br />

lymphoma and chronic lymphocytic leukemia. Blood. 2010;115:2578-<br />

2585.<br />

25. Friedberg JW. Double-hit diffuse large B-cell lymphoma. J Clin Oncol.<br />

2012;30:3439-3443.<br />

26. Kang MH, Reynolds CP. Bcl-2 inhibitors: Targeting mitochondrial apoptotic<br />

pathways in cancer therapy. Clin Cancer Res. 2009;15:1126-<br />

1132.<br />

27. Lossos IS, Morgensztern D. Prognostic biomarkers in diffuse large<br />

B-cell lymphoma. J Clin Oncol. 2006;24:995-1007.<br />

28. Souers AJ, Leverson JD, Boghaert ER, et al. ABT-199, a potent and selective<br />

BCL-2 inhibitor, achieves antitumor activity while sparing platelets.<br />

Nat Med. 2013;19:202-208.<br />

29. Vandenberg CJ, Cory S. ABT-199, a new Bcl-2-specifıc BH3 mimetic,<br />

has in vivo effıcacy against aggressive Myc-driven mouse lymphomas<br />

without provoking thrombocytopenia. Blood. 2013;121:2285-2288.<br />

30. Ruan J, Martin P, Furman RR, et al. Bortezomib plus CHOP-rituximab<br />

for previously untreated diffuse large B-cell lymphoma and mantle cell<br />

lymphoma. J Clin Oncol. 2011;29:690-697.<br />

31. Witzig TE, Tang H, Micallef IN, et al. Multi-institutional phase II study<br />

of the farnesyltransferase inhibitor tipifarnib (R115777) in patients with<br />

relapsed and refractory lymphomas. Blood. 2011;118:4882-4889.<br />

32. Mraz M, Zent CS, Church AK, et al. Bone marrow stromal cells protect<br />

lymphoma B-cells from rituximab-induced apoptosis and targeting integrin<br />

alpha-4-beta-1 (VLA-4) with natalizumab can overcome this resistance.<br />

Br J Haematol. 2011;155:53-64.<br />

33. Chiappella A, Tucci A, Castellino A, et al. Lenalidomide plus cyclophosphamide,<br />

doxorubicin, vincristine, prednisone and rituximab is<br />

safe and effective in untreated, elderly patients with diffuse large<br />

B-cell lymphoma: a phase I study by the Fondazione Italiana Linfomi.<br />

Haematologica. 2013;98:1732-1738.<br />

34. Nowakowski GS, LaPlant B, Habermann TM, et al. Lenalidomide can be<br />

safely combined with R-CHOP (R2CHOP) in the initial chemotherapy<br />

for aggressive B-cell lymphomas: phase I study. Leukemia. 2011;25:<br />

1877-1881.<br />

35. Nowakowski GS, LaPlant BR, Reeder C, et al. Combination of lenalidomide<br />

with R-CHOP (R2CHOP) is well-tolerated and effective as initial<br />

therapy for aggressive B-cell lymphomas - a phase II study. Blood. 2012;<br />

120 (suppl; abstr 689).<br />

36. Vitolo U, Chiappella A, Franceschetti S, et al. Lenalidomide plus<br />

R-CHOP21 in elderly patients with untreated diffuse large B-cell lymphoma:<br />

results of the REAL07 open-label, multicentre, phase 2 trial.<br />

Lancet Oncol. 2014;15:730-737.<br />

37. Nowakowski GS, LaPlant B, Macon WR. Lenalidomide combined with<br />

R-CHOP overcomes negative prognostic impact of non-germinal center<br />

B-cell phenotype in newly diagnosed diffuse large B-cell lymphoma:<br />

a phase II study. J Clin Oncol. 2015;33:251-257.<br />

38. Tsujimoto Y, Finger LR, Yunis J, et al. Cloning of the chromosome<br />

breakpoint of neoplastic B cells with the t(14;18) chromosome translocation.<br />

Science. 1984;226:1097-1099.<br />

39. Younes A, Flinn I, Berdeja J, et al. Combining ibrutinib with rituximab,<br />

cyclophosphamide, doxorubicin, vincristine, and prednisone (R-<br />

CHOP): updated results from a phase 1b study in treatment-naïve patients<br />

with CD20-positive B-cell non-Hodgkin’s lymphoma (NHL).<br />

Blood. 2013;122 (suppl; abstr 852).<br />

40. Gisselbrecht C, Glass B, Mounier N, et al. Salvage regimens with autologous<br />

transplantation for relapsed large B-cell lymphoma in the rituximab<br />

era. J Clin Oncol. 2010;28:4184-4190.<br />

41. Hernandez-Ilizaliturri FJ, Deeb G, Zinzani PL, et al. Higher response to<br />

lenalidomide in relapsed/refractory diffuse large B-cell lymphoma in<br />

nongerminal center B-cell-like than in germinal center B-cell-like phenotype.<br />

Cancer. 2011;117:5058-5066.<br />

42. Ott G, Rosenwald A, Campo E. Understanding MYC-driven aggressive<br />

B-cell lymphomas: pathogenesis and classifıcation. Blood. 2013;122:<br />

3884-3891.<br />

43. Sewastianik T, Prochorec-Sobieszek M, Chapuy B, et al. MYC deregulation<br />

in lymphoid tumors: Molecular mechanisms, clinical consequences<br />

and therapeutic implications. Biochim Biochim Biophys Acta.<br />

2014;1846;457-467.<br />

44. Karube K, Campo E. MYC Alterations in Diffuse Large B-Cell Lymphomas.<br />

Seminars in Hematology. In press.<br />

45. Pedersen MO, Gang AO, Poulsen TS, et al. MYC translocation partner<br />

gene determines survival of patients with large B-cell lymphoma with<br />

MYC- or double-hit MYC/BCL2 translocations. Eur J Haematol. 2014;<br />

92:42-48.<br />

46. Pasqualucci L, Neumeister P, Goossens T, et al. Hypermutation of multiple<br />

proto-oncogenes in B-cell diffuse large-cell lymphomas. Nature.<br />

2001;412:341-346.<br />

47. Stasik CJ, Nitta H, Zhang W, et al. Increased MYC gene copy number<br />

correlates with increased mRNA levels in diffuse large B-cell lymphoma.<br />

Haematologica. 2010;95:597-603.<br />

48 Barrans S, Crouch S, Smith A, et al. Rearrangement of MYC is associated<br />

with poor prognosis in patients with diffuse large B-cell lymphoma<br />

treated in the era of rituximab. J Clin Oncol. 2010;28:3360-3365.<br />

49. Valera A, Lopez-Guillermo A, Cardesa-Salzmann T, et al. MYC protein<br />

expression and genetic alterations have prognostic impact in patients<br />

with diffuse large B-cell lymphoma treated with immunochemotherapy.<br />

Haematologica. 2013;98:1554-1562.<br />

50. Petrich AM, Gandhi M, Jovanovic B, et al. Impact of induction regimen<br />

and stem cell transplantation on outcomes in double-hit lymphoma: A<br />

multicenter retrospective analysis. Blood. 2014;124:2354-2361.<br />

51. Green TM, Young KH, Visco C, et al. Immunohistochemical double-hit<br />

score is a strong predictor of outcome in patients with diffuse large<br />

e456<br />

2015 ASCO EDUCATIONAL BOOK | asco.org/edbook

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!