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EDWARD S. KIM TABLE 1. Selected Umbrella and Master Trials Title Short Name Sponsor Accrual Dates Biomarker-Integrated BATTLE MD Anderson Cancer Approaches of Targeted Center Therapy for Lung Cancer Elimination BATTLE-2 Program: A Biomarker-Integrated Targeted Therapy Study BATTLE-2 MD Anderson Cancer Center Lung Cancer Master Protocol Lung-MAP Southwest Oncology Group Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging And Molecular Analysis 1 Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging And Molecular Analysis 2 Molecular Analysis for Therapy Choice Initiative for Molecular Profiling in Advanced Cancer Therapy (IMPACT) Trial, An Umbrella Protocol Molecular Profiling-Based Assignment of Cancer Therapeutics Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial I-SPY1 I-SPY2 NCI MATCH IMPACT NCI MPACT ALCHEMIST National Cancer Institute QuantumLeap Healthcare Collaborative National Cancer Institute MD Anderson Cancer Center National Cancer Institute National Cancer Institute Estimated Enrollment Cancer Types Treatment Biomarkers 2006-2015 250 Non-small cell lung 2011-2017 450 Non-small cell lung 2014-2022 Up to 10,000 screened Squamous cell lung Erlotinib, sorafenib, vandetanib, erlotinib bexarotene Erlotinib, AZD6244, MK-2206, sorafenib MEDI4736, GDC-0032, palbociclib isethionate, AZD4547, rilotumumab, docetaxel, erlotinib hydrochloride 2002-2010 356 Stage II-III breast Standard neoadjuvant anthracycline-based chemotherapy, with or without a taxane 2010-2015 800 Locally advanced breast Opening early 2015 Up to 3,000 screened for biomarkers, approximately 1,000 treated 2009-2016 Approximately 5,000 2014-2017 700 to be screened, 180 to be enrolled on treatment 2014-2020 Up to 8,000 screened Advanced solid tumors, lymphoma Advanced cancers Advanced cancers Early-stage non-small cell lung Standard therapy, AMG 386, AMG 479 (ganitumab) metformin, MK-2206 with or without trastuzumab, AMG 386 trastuzumab, T-DM1 pertuzumab, pertuzumab trastuzumab, ganetespib 20-25 targeted agents (e.g., imatinib, erlotinib, crizotinib, trastuzumab, vemurafenib) None Temozolomide, everolimus, carboplatin, trametinib DMSO, ABT-888, MK-1775 Erlotinib hydrochloride, crizotinib EGFR, KRAS, BRAF, CCND1, VEGF, VEGFR-2, RXRs, cyclin D-1 EGFR, KRAS, EML4/ALK PIK3CA, CCND1, D2, CDK4, FGFR Hormone and HER2 expression Hormone and HER2 expression EGFR, HER2, MET, BRAF, NF1, GNAQ, GNA11, TSC1/2, PTEN, Patch, NF2, ALK, ROS, FGFR EGFR, VEGF, HIF-1, PI3K, RAS, RAF, MEK, cytokines, interleukins DNA repair pathways, PI3K, or RAS/RAF/MEK EGFR, ALK Safeway Foundation, Biomarkers Consortium, Quintiles, and QuantumLeap Health Care Collaborative. The goal of I-SPY 1 was to identify predictors of response to neoadjuvant chemotherapy for women with stage II/III cancer. A total of 356 women were enrolled; biomarker information and MRI results were obtained. Researchers found that certain tumor profıles responded better than others to particular drugs. Results from I-SPY 1 guided the design of I-SPY 2, an adaptive, randomized trial that uses early data to guide treatment decisions for those enrolled later in the trial. Approximately 800 women will be enrolled in this trial of multiple drugs. 12 ALCHEMIST The NCI has launched initiatives to study patients with unique biomarkers and targeted therapy in both early- and advanced-stage cancer settings. The Adjuvant Lung Cancer Enrichment Marker Identifıcation and Sequencing Trial (ALCHEMIST) series is focused on patients diagnosed with early-stage lung cancer. The series of trials consists of a screening trial and two treatment trials (EGFR-targeted therapies and ALK-targeted therapies). Approximately 6,000 to 8,000 patients will be enrolled in the screening trial over the next 5 to 6 years with the goal of determining if selection of therapy based on these molecular markers leads to improved survival. Tumor biopsies from these patients will be evaluated for EGFR and ALK abnormalities. Patients whose tumors harbor one of these mutations will be directed into the appropriate biologic treatment trial (erlotinib if EGFR is mutated and crizotinib if ALK is abnormal vs. placebo). Each treatment trial is expected to enroll approximately 400 patients. 13 MASTER STUDIES NCI MATCH Another NCI-sponsored study, NCI MATCH (The NCI Molecular Analysis for Therapy Choice Trial), will enroll patients with advanced solid tumors (gastrointestinal stromal tumor, NSCLC, breast, gastric, melanoma, thyroid) and lym- 24 2015 ASCO EDUCATIONAL BOOK | asco.org/edbook
THE FUTURE OF MOLECULAR MEDICINE phomas. Biopsies from approximately 3,000 patients will undergo testing for abnormalities that may respond to targeted drug therapies. Of these patients, up to 1,000 will then participate in phase II clinical trials of targeted drug therapies. The patients will be matched to the drug based solely on the genetic abnormality, not on the type of cancer. NCI MATCH is a master trial, meaning that new drugs can be added to the trial at any time. The primary endpoint for this trial is response, however, progression-free survival will also be assessed. 14 A new public/private cooperative effort is Lung-MAP (Lung Master Protocol). This study will enroll 500 to 1,000 patients diagnosed with advanced, previously treated squamous cell lung cancer each year. The molecular profıling is done with a central commercial panel and places patients into different arms with biologic therapies. One feature of this study is that patients who do not meet the criteria for treatment with a targeted therapy are placed into a trial involving a nontargeted investigational treatment. The primary objective of this trial is to determine if the effıcacy of targeted therapy is better than that of standard therapy. 15 M-PACT In the NCI-sponsored M-PACT (Molecular Profıling–Based Assignment of Cancer Therapeutics trial), patients with advanced tumors that have progressed on at least one line of standard therapy undergo tumor biopsy to determine if a mutation is present. Those who do not have an identifıable mutation are removed from the trial. Those who do have a mutation are randomly assigned to receive either treatment with a drug known to target their mutation or treatment with a drug not known to target their mutation. Cross-over is allowed for those who experience disease progression after receiving treatment with a drug not known to target their mutation. Tumor response and 4-month progression-free survival are the endpoints in this trial. Accrual to this trial began in 2014 and approximately 700 patients are expected to be screened, with over 150 to be enrolled in a treatment arm. The goal is to determine whether therapies targeting a mutation can work in the metastatic setting. 16 There is a need to test the approach in different settings, leading to many umbrella and master studies required to answer the overarching question of whether therapies targeting molecular aberrations lead to better outcomes for patients over standard chemotherapy, and in what types of patients, tumors, or aberrations these treatments work (or do not work). The importance of these efforts is not only the testing of the specifıc targeted therapies, but the collection and storage of centralized tissue and molecular data. These collections will allow large amounts of data to be analyzed with the hope of someday developing predictive treatment models for patients. BIG DATA Big data is defıned as any voluminous amount of structured, semi-structured, and unstructured data that has the potential to be mined for information. More specifıcally, big data is any data whose scale, diversity, and complexity require new architecture, techniques, algorithms, and analytics to manage it as well as to extract value and hidden knowledge from it. Big data expands across four fronts: velocity, variety, volume, and veracity (Table 2). 17,18 Capturing big data in databases may help formulate hypotheses for testing. Statistical testing can be performed on preexisting data to facilitate this process. However, big data collection can be compromised by bias in medical records, lack of data validity and reliability, and technology challenges. The potential for misinterpretation of the data is paramount. Additionally, the structure of electronic medical records may be poorly suited for adequate data abstraction and are certainly not suited for numerous secondary analyses. Many institutions also have different platforms, which can impede data integration. Attention to privacy, sharing, transparency, and stewardship are all guiding principles for big data collection and analysis. Medicine, specifıcally cancer medicine, is encountering this dilemma. As the amount of information exponentially increases (patient clinical information, pathology, biomarkers, treatment outcomes, and patient questionnaires), the prospect of harnessing and processing this data is daunting. However, the potential rewards make it worth the effort. Numerous companies and researchers are working to integrate and interrogate these data sets with expectations that they will identify new opportunities for treatment, diagnosis, prognosis, and prevention. Nontraditional groups are joining the foray into this area, including Google and fınancial institutions, because of their ability to collect a variety of data on inordinately large numbers of individuals and variables (e.g., search, purchasing, and other behaviors). ASCO CANCERLINQ The American Society of Clinical Oncology (ASCO) has established an important initiative called CancerLinQ TM (www.CancerLinQ.org), a health information technology TABLE 2. The Four Fronts of Big Data Fronts Velocity Variety Volume Veracity Description The velocity of cancer medicine is ever increasing as the number of patient encounters, molecular tests, and treatments grows. Data platforms in cancer medicine continue to rapidly evolve. The electronic health record is becoming a better resource as a database. More and more hospital systems are incorporating telemedicine which enlist mobile connectivity. Archived data mining is now becoming active data searches. The amount of information that is being generated by cancer medicine is being measured in the scope of peta- and exabytes. Storage solutions must be forward-thinking, including current cloud sourcing. The reliability of data sources in the health care setting is not always ideal, as most systems are not set up for research. Large data sets can be subject to bias. We should be prepared to acknowledge the limitations of our data. asco.org/edbook | 2015 ASCO EDUCATIONAL BOOK 25
Page 1 and 2: AMERICAN SOCIETY OF CLINICAL ONCOLO
Page 3: American Society of Clinical Oncolo
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Page 16 and 17: 2015 ASCO Annual Meeting Disclosure
Page 18 and 19: 2015 Educational Book Expert Panel
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DECISION MAKING IN THE CONTEXT OF B
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CAN DIET AND LIFESTYLE PREVENT BREA
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REFORMING THE BUY-AND-BILL CHEMOTHE
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CARE DELIVERY AND PRACTICE MANAGEME
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THE PATIENT-CENTERED MEDICAL HOME c
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INTEGRATING ICD-10 IN YOUR PRACTICE
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CENTRAL NERVOUS SYSTEM TUMORS Brain
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AHLUWALIA AND WINKLER TARGETING ANG
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AHLUWALIA AND WINKLER However, the
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MEHTA AND AHLUWALIA of SRS for brai
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MAWRIN, CHUNG, AND PREUSSER Biology
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DEVELOPMENTAL THERAPEUTICS AND TRAN
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ESTEVA, MILLER, AND TEICHER TARGETS
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ESTEVA, MILLER, AND TEICHER gle che
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ESTEVA, MILLER, AND TEICHER TABLE 2
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STUART M. LICHTMAN include a Geriat
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STUART M. LICHTMAN an outcome of ca
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BARRIOS, WERUTSKY, AND MARTINEZ-MES
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RIMAWI, DE ANGELIS, AND SCHIFF tent
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CHRISTINE M. LOVLY TKIs have been t
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CHRISTINE M. LOVLY MAP2K1, which en
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CHRISTINE M. LOVLY patients with ad
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DAMODARAN, BERGER, AND ROYCHOWDHURY
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ZARDAVAS AND PICCART-GEBHART TABLE
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ZARDAVAS AND PICCART-GEBHART TABLE
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ZARDAVAS AND PICCART-GEBHART triple
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ZARDAVAS AND PICCART-GEBHART mutati
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MICHAEL A. POSTOW Managing Immune C
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MICHAEL A. POSTOW diarrhea symptoms
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MICHAEL A. POSTOW tion. One of thes
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MICHAEL A. POSTOW nitis during ipil
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GASTROINTESTINAL (COLORECTAL) CANCE
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PRECISION THERAPY FOR RECTAL CANCER
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PRECISION THERAPY FOR RECTAL CANCER
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GASTROINTESTINAL (COLORECTAL) CANCE
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MARWAN FAKIH was offset by a detrim
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MARWAN FAKIH TABLE 1. Biologicals i
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MARWAN FAKIH TABLE 3. EGFR Targetin
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MARWAN FAKIH TABLE 6. EGFR Targetin
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MARWAN FAKIH 5-fluorouracil (FOLFIR
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PUNT, SIMKENS, AND KOOPMAN 5-FU/LV
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PUNT, SIMKENS, AND KOOPMAN TABLE 1.
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PUNT, SIMKENS, AND KOOPMAN 35. Veno
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CERCEK, CUSACK, AND RYAN Treatment
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CERCEK, CUSACK, AND RYAN leagues pe
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GASTROINTESTINAL (NONCOLORECTAL) CA
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ABOU-ALFA ET AL sess liver function
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ABOU-ALFA ET AL tinuing liver injur
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ABOU-ALFA ET AL mors including HCC,
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ABOU-ALFA ET AL HCC (Anti-Programme
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AHN ET AL Making Sense of Current a
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AHN ET AL Pancreatic cancer has bee
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AHN ET AL Disclosures of Potential
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EGIDIO DEL FABBRO tion of precachex
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EGIDIO DEL FABBRO FIGURE 3. Mechani
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EGIDIO DEL FABBRO II RCT of ghrelin
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EGIDIO DEL FABBRO 22. Tan BH, Birds
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THE SPECTRUM OF NEUROENDOCRINE TUMO
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CHALLENGING THE TREATMENT PARADIGM
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STAGE I TESTICULAR GERM CELL CANCER
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STAGE I TESTICULAR GERM CELL CANCER
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GERM CELL TUMORS: LOOKING TO THE FU
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SALVAGE CHEMOTHERAPY Salvage Therap
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SALVAGE CHEMOTHERAPY References 1.
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EARLY CHEMOTHERAPY IN MEN WITH META
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RADIUM 223 AND METASTATIC CASTRATIO
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RADIUM 223 AND METASTATIC CASTRATIO
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IMMUNOTHERAPY FOR PROSTATE TUMORS I
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IMMUNOTHERAPY FOR PROSTATE TUMORS a
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EVOLVING IMMUNOTHERAPY STRATEGIES I
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NOVEL IMMUNOTHERAPY AGENTS IN METAS
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PROMISING STRATEGIES IN BLADDER CAN
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GYNECOLOGIC CANCER Cervical Cancer
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MACKAY, WENZEL, AND MILESHKIN In th
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MACKAY, WENZEL, AND MILESHKIN TABLE
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MACKAY, WENZEL, AND MILESHKIN ing s
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MACKAY, WENZEL, AND MILESHKIN 59. F
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GYNECOLOGIC CANCER Managing Ovarian
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DUSKA, TEW, AND MOORE KEY POINTS A
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DUSKA, TEW, AND MOORE FIGURE 2. Sur
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DUSKA, TEW, AND MOORE FIGURE 3. Che
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DUSKA, TEW, AND MOORE FIGURE 4. Ger
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DUSKA, TEW, AND MOORE 10. Griffıth
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GYNECOLOGIC CANCER Treatment of the
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CHEMOTHERAPY FOR PATIENTS WITH BMOC
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PROGRESS IN HEAD AND NECK SQUAMOUS
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HEAD AND NECK CANCER PI3-Kinase: Ge
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ISAACSSON VELHO, CASTRO JR, AND CHU
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SHARON H. GIORDANO Comparative Effe
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SHARON H. GIORDANO measured confoun
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SHARON H. GIORDANO These databases
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HEALTH SERVICES RESEARCH AND QUALIT
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INDUSTRY AND ONCOLOGY KEY POINTS F
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INDUSTRY AND ONCOLOGY has been “l
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INDUSTRY AND ONCOLOGY by (covered)
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INDUSTRY AND ONCOLOGY 42. World Hea
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CANCER CARE QUALITY: CURRENT STATE
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MANAGING OLDER PATIENTS WITH ALL Th
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MANAGING OLDER PATIENTS WITH ALL TA
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MANAGING OLDER PATIENTS WITH ALL FI
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MANAGING OLDER PATIENTS WITH ALL FI
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MANAGING OLDER PATIENTS WITH ALL ra
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TREATMENT OF PHILADELPHIA CHROMOSOM
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CD19 CAR THERAPY FOR ALL FIGURE 1.
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CD19 CAR THERAPY FOR ALL 5. Zhou G,
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NEW TARGETED THERAPIES FOR iNHL New
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NEW TARGETED THERAPIES FOR iNHL TAB
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NEW TARGETED THERAPIES FOR iNHL a P
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HEMATOPOIETIC CELL TRANSPLANTATION
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LEUKEMIA, MYELODYSPLASIA, AND TRANS
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MICHAEL W. DEININGER TABLE 1. Defin
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MICHAEL W. DEININGER the ATP-bindin
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MICHAEL W. DEININGER broad range ef
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MICHAEL W. DEININGER 30. Hughes T,
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PEMMARAJU AND MOLITERNO TABLE 1. Ac
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PEMMARAJU AND MOLITERNO drome (BCS)
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PEMMARAJU AND MOLITERNO 13. Xing S,
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THERAPIES AND INDICATIONS FOR PH-NE
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LEUKEMIA, MYELODYSPLASIA, AND TRANS
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RECENT UPDATES IN MDS AND MDS/MPNS
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LUNG CANCER Beyond Second-Line Trea
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BEYOND SECOND-LINE TREATMENT FOR LU
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BEYOND SECOND-LINE TREATMENT FOR LU
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LUNG CANCER New Therapies for Histo
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GERBER, PAIK, AND DOWLATI a tumor t
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GERBER, PAIK, AND DOWLATI squamous
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GERBER, PAIK, AND DOWLATI FIGURE 2.
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GERBER, PAIK, AND DOWLATI TABLE 1.
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GERBER, PAIK, AND DOWLATI gression
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GERBER, PAIK, AND DOWLATI Disclosur
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GERBER, PAIK, AND DOWLATI enzyme in
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GERBER, PAIK, AND DOWLATI receptor
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LILENBAUM, LEIGHL, AND NEUBAUER Exp
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LILENBAUM, LEIGHL, AND NEUBAUER tha
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LILENBAUM, LEIGHL, AND NEUBAUER Ref
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BERNARDO H.L. GOULART The Value of
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BERNARDO H.L. GOULART TABLE 1. Expe
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BERNARDO H.L. GOULART every 6 month
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BERNARDO H.L. GOULART lung-cancer/l
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LUNG CANCER Updates in the Multimod
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WOODARD AND JABLONS section, becaus
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WOODARD AND JABLONS mediastinum is
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WOODARD AND JABLONS FIGURE 1. Molec
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NASSER HANNA Current Standards and
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NASSER HANNA At the 2014 ASCO Annua
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NASSER HANNA culty of this task. Va
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LYMPHOMA AND PLASMA CELL DISORDERS
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NOWAKOWSKI AND CZUCZMAN sociated wi
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NOWAKOWSKI AND CZUCZMAN trial is in
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NOWAKOWSKI AND CZUCZMAN TABLE 2. DH
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NOWAKOWSKI AND CZUCZMAN 15. Aragon-
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DAVID W. SCOTT Cell-of-Origin in Di
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DAVID W. SCOTT FIGURE 1. The Origin
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DAVID W. SCOTT FIGURE 2. Immunohist
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DAVID W. SCOTT FIGURE 3. The Lymph2
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DAVID W. SCOTT 10. Shaffer AL 3rd,
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CHEAH, OKI, AND FANALE Novel Treatm
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CHEAH, OKI, AND FANALE an ongoing G
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CHEAH, OKI, AND FANALE a similar me
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CHEAH, OKI, AND FANALE TABLE 3. Sel
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CHEAH, OKI, AND FANALE eral T cell
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CHEAH, OKI, AND FANALE 77. Cairns R
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STEPHEN ANSELL associated with pati
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STEPHEN ANSELL Disclosures of Poten
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MATEOS AND SAN MIGUEL Smoldering Mu
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MATEOS AND SAN MIGUEL years. This f
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MATEOS AND SAN MIGUEL previously me
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MATEOS AND SAN MIGUEL TABLE 2. Risk
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MATEOS AND SAN MIGUEL 30. Rajkumar
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BHUTANI, LANDGREN, AND USMANI of th
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BHUTANI, LANDGREN, AND USMANI bette
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BHUTANI, LANDGREN, AND USMANI fıne
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BHUTANI, LANDGREN, AND USMANI FIGUR
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BHUTANI, LANDGREN, AND USMANI 15. K
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MOREAU AND TOUZEAU Multiple Myeloma
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MOREAU AND TOUZEAU other effıcacy
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MOREAU AND TOUZEAU was able to indu
Page 696 and 697:
MOREAU AND TOUZEAU Group consensus
Page 698 and 699:
LYMPHOMA AND PLASMA CELL DISORDERS
Page 700 and 701:
MANAGEMENT OF CLL Up-Front Manageme
Page 702 and 703:
MANAGEMENT OF CLL than 17p-/TP53mut
Page 704 and 705:
MANAGEMENT OF CLL could be associat
Page 706 and 707:
MANAGEMENT OF CLL tion by nonmalign
Page 708 and 709:
MANAGEMENT OF CLL fludarabine and c
Page 710 and 711:
MANAGEMENT OF CLL lymphocytic leuke
Page 712 and 713:
PROGNOSTIC FACTORS AND ADJUVANT RAD
Page 714 and 715:
Page 716 and 717:
Page 718 and 719:
MERKEL CELL CARCINOMA Merkel Cell C
Page 720 and 721:
MERKEL CELL CARCINOMA tions in PIK3
Page 722 and 723:
MERKEL CELL CARCINOMA treating MCC
Page 724 and 725:
MERKEL CELL CARCINOMA 32. Leonard J
Page 726 and 727:
MELANOMA/SKIN CANCERS Locoregional
Page 728 and 729:
PERFUSION AND INFUSION IN THE ERA O
Page 730 and 731:
Page 732 and 733:
Page 734 and 735:
NEOADJUVANT THERAPY OF MELANOMA Neo
Page 736 and 737:
NEOADJUVANT THERAPY OF MELANOMA TAB
Page 738 and 739:
NEOADJUVANT THERAPY OF MELANOMA ity
Page 740 and 741:
NEOADJUVANT THERAPY OF MELANOMA 4.
Page 742 and 743:
MELANOMA/SKIN CANCERS Targeted Mole
Page 744 and 745:
SULLIVAN ET AL FIGURE 1. Relevant S
Page 746 and 747:
SULLIVAN ET AL Resistance to BRAF i
Page 748 and 749:
SULLIVAN ET AL TABLE 1. Clinical Tr
Page 750 and 751:
SULLIVAN ET AL 17. Halait H, Demart
Page 752 and 753:
SULLIVAN ET AL NRAS-mutant melanoma
Page 754 and 755:
KLEPIN, RODIN, AND HURRIA Treating
Page 756 and 757:
KLEPIN, RODIN, AND HURRIA plication
Page 758 and 759:
KLEPIN, RODIN, AND HURRIA plan was
Page 760 and 761:
KLEPIN, RODIN, AND HURRIA patient-s
Page 762 and 763:
KLEPIN, RODIN, AND HURRIA 62. Blanc
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PERIPHERAL NEUROTOXICITY IN CANCER
Page 766 and 767:
Page 768 and 769:
Page 770 and 771:
Page 772 and 773:
PARTRIDGE, JACOBSEN, AND ANDERSEN C
Page 774 and 775:
PARTRIDGE, JACOBSEN, AND ANDERSEN c
Page 776 and 777:
PARTRIDGE, JACOBSEN, AND ANDERSEN w
Page 778 and 779:
PARTRIDGE, JACOBSEN, AND ANDERSEN v
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LESLIE R. SCHOVER Sexual Healing in
Page 782 and 783:
LESLIE R. SCHOVER tinuous ADT in pr
Page 784 and 785:
LESLIE R. SCHOVER 12. Potosky AL, H
Page 786 and 787:
CATHERINE H. VAN POZNAK TABLE 1. Wo
Page 788 and 789:
CATHERINE H. VAN POZNAK (tamoxifen,
Page 790 and 791:
CATHERINE H. VAN POZNAK TABLE 3. FD
Page 792 and 793:
CATHERINE H. VAN POZNAK premenopaus
Page 794 and 795:
SHARI GOLDFARB KEY POINTS Brea
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SHARI GOLDFARB and friction with va
Page 798 and 799:
SHARI GOLDFARB importance both duri
Page 800 and 801:
PATIENT AND SURVIVOR CARE Moving Su
Page 802 and 803:
MAYER ET AL TABLE 1. Quality Metric
Page 804 and 805:
MAYER ET AL to enhance the quality
Page 806 and 807:
MAYER ET AL FIGURE 2. (A) Infertili
Page 808 and 809:
MAYER ET AL efıcial suggests that
Page 810 and 811:
PATIENT AND SURVIVOR CARE The Chall
Page 812 and 813:
BRUERA AND PAICE Choice of Opioid a
Page 814 and 815:
BRUERA AND PAICE toxicity and proce
Page 816 and 817:
BRUERA AND PAICE effective. Basic s
Page 818 and 819:
PEDIATRIC ONCOLOGY Real-Time Molecu
Page 820 and 821:
CARROLL, RAETZ, AND MEYER KEY POINT
Page 822 and 823:
CARROLL, RAETZ, AND MEYER most are
Page 824 and 825:
CARROLL, RAETZ, AND MEYER markers a
Page 826 and 827:
PEDIATRIC ONCOLOGY Translating Surv
Page 828 and 829:
REDUCING THE BURDEN OF LATE EFFECTS
Page 830 and 831:
Page 832 and 833:
Page 834 and 835:
Page 836 and 837:
PROFESSIONAL DEVELOPMENT The Challe
Page 838 and 839:
ADVANCES IN WEBSITE INFORMATION RES
Page 840 and 841:
Page 842 and 843:
Page 844 and 845:
Page 846 and 847:
COMMUNICATION AND TECHNOLOGY: IT’
Page 848 and 849:
Page 850 and 851:
Page 852 and 853:
PATIENT-REPORTED OUTCOMES IN ONCOLO
Page 854 and 855:
PATIENT-REPORTED OUTCOMES IN ONCOLO
Page 856 and 857:
PROFESSIONAL DEVELOPMENT Trends, An
Page 858 and 859:
CLINICAL ONCOLOGY PRACTICE 2015 FIG
Page 860 and 861:
CLINICAL ONCOLOGY PRACTICE 2015 (6.
Page 862 and 863:
CLINICAL ONCOLOGY PRACTICE 2015 Pro
Page 864 and 865:
ADJUVANT/NEOADJUVANT MEDICAL THERAP
Page 866 and 867:
Page 868 and 869:
Page 870 and 871:
INDICATIONS FOR ADJUVANT RADIATION
Page 872 and 873:
Page 874 and 875:
Page 876 and 877:
Page 878 and 879:
SARCOMA Latest Advances in Systemic
Page 880 and 881:
SYSTEMIC THERAPY FOR OSTEOSARCOMA A
Page 882 and 883:
SYSTEMIC THERAPY FOR OSTEOSARCOMA A
Page 884 and 885:
RETHINKING TREATMENT FOR CHONDROSAR
Page 886 and 887:
Page 888 and 889:
Page 890 and 891:
Page 892 and 893:
BONE SARCOMAS IN ADULTS local disea
Page 894 and 895:
BONE SARCOMAS IN ADULTS structure a
Page 896 and 897:
SARCOMA Well-Differentiated and Ded
Page 898 and 899:
ABBAS MANJI ET AL ticular region. 7
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ABBAS MANJI ET AL MYXOID (ROUND CEL
Page 902 and 903:
ABBAS MANJI ET AL versus doxorubici
Page 904 and 905:
SHLUSH AND HERSHKOVITZ Clonal Evolu
Page 906 and 907:
SHLUSH AND HERSHKOVITZ FIGURE 1. Ti
Page 908 and 909:
TUMOR BIOLOGY New Strategies to Und
Page 910 and 911:
KNAPP, DHAWAN, AND OSTRANDER in dog
Page 912 and 913:
KNAPP, DHAWAN, AND OSTRANDER TABLE
Page 914 and 915:
KNAPP, DHAWAN, AND OSTRANDER 14. Fe
Page 916 and 917:
SOURBIER, SRINIVASAN, AND LINEHAN M
Page 918 and 919:
SOURBIER, SRINIVASAN, AND LINEHAN F
Page 920 and 921:
SOURBIER, SRINIVASAN, AND LINEHAN T
Page 922:
Author Index Abbas Manji, Gulam ...
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