Scientific Concept of the National Cohort (status ... - Nationale Kohorte

A.3
A.3 Study design
ticipants and fixed. Participants will be instructed to return the device to the study center by
mail at the end of the 7-day assessment period.
In the intensively investigated group (Level 2) a more in-depth phenotyping will be conducted.
In addition to the Level 1 examination program, study participants belonging to this
group will get further examinations related to the cardiovascular system, glucose metabolism
(diabetes), respiratory diseases, the musculoskeletal system, oral health, sense organ
functions, and physical activity and fitness (Table 3.7).
Table 3.7: Baseline physical examinations at level 1 (n=200,000) and level 2 (n=40,000)
Cardiovascular examinations:
Instruments Level 1
86
(duration)
- Blood pressure and heart rate 7 min
- Electrocardiography (10-sec. ECG; 12 leads) 8 min
- 3-D-Echocardiography 6 min
- Combined device (e.g., Vascular Explorer)*:
Arterial stiffness, Ankle Brachial Index, etc.
10 min
Level 2
(duration)
- Carotic sonography, intima–media thickness 10 min
- Long-term ECG / apnea device* 5 min
Diabetes-related measurements:
- Oral glucose tolerance test (OGTT)
- AGE reader (skin AF)
Cognitive function:
- Test battery*
Lung function:
10 min
- Spirometry 8 min
5 min
4 min
10 min
- Nitric oxide (FeNO) in exhaled air 6 min
Musculo-skeletal system:
- Medical examination*
Oral health:
- Tooth count 1 min
10 min
- Oral examination* 10 min
Sense organs:
- Ophtalmological measurements 10 min
- Hearing test (touch screen, headphone)† 4 min
- Olfactory test (sniffin’-sticks 12) 5 min