Scientific Concept of the National Cohort (status ... - Nationale Kohorte

Table S6.3: Minimum detectable odds ratio (MDOR; statistical power 0.80, significance level of either 0.05 or 10
Table S6.3: Minimum detectable odds ratio (MDOR; statistical power 0.80, significance level of either 0.05 or 10-4) for comparison of top to bottom quartiles
of a continuous exposure variable by number of controls per cases.
-4 ) for comparison of top to bottom
quartiles of a continuous exposure variable by number of controls per cases.
Minimum detectable OR for comparison of top to bottom quartiles
Case to
Critical 150 200 300 400 500 700 1,000 1,500 2,000 2,500 3,000 4,000 5,000 10,000
control ratio
p-value cases cases cases cases cases cases cases cases cases cases cases cases cases cases
(unmatched)
1:1 0.05 2.4 2.1 1.9 1.7 1.6 1.5 1.4 1.3 1.3 1.2 1.2 1.18 1.16 1.11
10 -4 7.2 5.3 3.8 3.1 2.8 2.3 2.0 1.8 1.6 1.6 1.5 1.4 1.4 1.2
1:2 0.05 2.1 1.9 1.7 1.6 1.5 1.4 1.3 1.3 1.2 1.2 1.18 1.16 1.14 1.10
10 -4 5.4 4.2 3.1 2.7 2.4 2.1 1.8 1.6 1.5 1.5 1.4 1.4 1.3 1.2
1:4 0.05 2.0 1.8 1.6 1.5 1.5 1.4 1.3 1.2 1.2 1.18 1.17 1.14 1.13 1.09
10 -4 4.6 3.6 2.8 2.4 2.2 2.0 1.7 1.6 1.5 1.4 1.4 1.3 1.3 1.2
Table * highlighted S6.4: Relationship are the combinations between where standardized MDOR is 1.5 difference or smaller A and expected Odds Ratio between extreme tertiles or quartiles of the exposure
distribution.
C.2 Annex: Methods for Statistical Power and Sample Size Calculations
Table S6.4: Relationship between standardized difference A and expected Odds Ratio between extreme tertiles or quartiles of the exposure distribution.
277
OR
over tertiles
OR
over quartiles
Standardized
difference A
0,05 1,14 1,12
0,08 1,23 1,19
0,10 1,29 1,25
0,15 1,46 1,39
0,20 1,66 1,55
0,25 1,89 1,73
0,30 2,14 1,93
0,35 2,43 2,16
0,40 2,76 2,41
C.2