Scientific Concept of the National Cohort (status ... - Nationale Kohorte

1000
0
1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 2.0 2.1 2.2 2.3 2.4 2.5
A.6 Planned statistical MDOR analyses and statistical power considerations
figure 6.3: Study size (number of disease cases, with 2 or 4 controls each) required for detection
of a minimum odds ratio [MDOR] varying from 1.2 to 2.5, between top to bottom quartiles of a
continuous exposure variable (statistical Power 0.80, at significant levels of 0.05 or 10-4 lb alpha=0.0001, 2 controls per case alpha=0.0001, 4 controls per case
alpha=0.05, 2 controls per case alpha=0.05, 4 controls per case
)
N cases
10000
9000
8000
N cases 7000
5000
6000
4500
5000
4000
4000
3500
3000
3000
2000
2500
1000
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0
1500
1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 2.0 2.1 2.2 2.3 2.4 2.5
1000
500
figure 6.4: Study size (number of disease cases, with 1, 2, or 4 controls each) required to detect
a minimal standardized difference A, in a continuous exposure variable* (statistical power 0.80, at
significance levels of 0.05 or 10-4 alpha=0.05, 1 control per case alpha=0.0001, 1 control per case
alpha=0.05, 2 control per case alpha=0.0001, 2 control per case
alpha=0.05, 4 control per case alpha=0.0001, 4 control per case
* Normal distributed covariable, equal variance in cases and controls
)
183
MDOR
01:12 Mittwoch, Februar 02, 2011 1
lb 0 alpha=0.0001, 2 controls per case alpha=0.0001, 4 controls per case
alpha=0.05, 2 controls per case alpha=0.05, 4 controls per case
N cases
5000
4500
4000
3500
3000
2500
2000
1500
1000
0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40
500
0
standardized difference (A)
0.05 0.10 0.15 0.20 0.25 0.30 0.35 0.40
standardized difference (A)
alpha=0.05, 1 control per case alpha=0.0001, 1 control per case
alpha=0.05, 2 control per case alpha=0.0001, 2 control per case
alpha=0.05, 4 control per case alpha=0.0001, 4 control per case
* Normal distributed covariable, equal variance in cases and controls
A.6