Scientific Concept of the National Cohort (status ... - Nationale Kohorte

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C.1 C.1 Annex: Description of the study centers such as the renowned heart center, more than half a million inpatients and outpatients are served per year. The Institute of medical Informatics, Statistics, and Epidemiology (IMISE) comprises strong expertise in clinical trials and biometry, medical informatics, and systems biology and bioinformatics. IMISE is involved in research networks such as “Verbundprojekt ‘Familiärer Darmkrebs’” and “Deutsche Studiengruppe für hochmaligne Non-Hodgkin Lymphome” (DSNHL). IMISE offshoots include the Center for Clinical Studies (ZKS), conducting more than 100 investigator-initiated or industry-led clinical trials, and the Interdisciplinary Center for Bioinformatics (IZBI). A main goal of IMISE is to contribute to improving health care and medical science through high-quality clinical trials and research into pathomechanisms of disease. In addition to the scientific expertise required in this context, a strong IT infrastructure has been established. The Institute of laboratory medicine, Clinical Chemistry, and molecular diagnostics (ILM) with its accredited laboratories provides a wide range of laboratory diagnostic services for the university hospitals and beyond. ILM performs newborn screening for the states of Saxony and Thuringia, is involved in numerous clinical trials as the central laboratory, and has a strong research agenda, for instance, for CVD. IMISE and ILM have been leading partners in establishing the “Leipzig Research Center for Diseases of Civilization” (LIFE). In LIFE, population cohorts of children and adults are recruited along with several disease cohorts, totaling more than 20,000 individuals. Detailed phenotypic characterization of participants comprises questionnaires and technical assessments of sociodemographics, disease history, anthropometry, and clinical and laboratory measurements. LIFE brings together scientists from many institutes and clinics and has strong links to the IFB Adiposity Diseases and the Max-Planck-Institute for Human Cognitive and Brain Sciences in Leipzig. IMISE in conjunction with ILM will run the study center Leipzig. Additional epidemiologic expertise is available from the study center Halle. We plan to recruit 10,000 participants for the National Cohort. In addition to level 1 assessments, assessments for levels 2 and 3 are envisioned. Description of the study center Leipzig In Leipzig 10,000 individuals will be recruited and will include inhabitants of the City of Leipzig with its population of 500,000. A subcohort comprising inhabitants of surrounding rural areas may be established. The study center has been established on the medical campus of the University of Leipzig, about 15 min walking distance to the center of the city. It is directly accessible by several tram lines, and a bus line and by car, linking the center to all neighborhoods of Leipzig as well as to the main railway station. The study center comprises rooms for interviews, questionnaires, anthropometry, ultrasound, echocardiography, ECG, physical assessments, and preanalytical preparation and interim storage of biosamples. A direct pneumatic delivery link to the main laboratory exists. Currently, IT infrastructure is being established for large cohort studies including data entry and storage, data transfer from instruments and instant laboratory measurements, and tracking of biomaterials. The location of the study center on the medical campus of the University of Leipzig facilitates close cooperation with clinicians and scientists and provides options for additional assessments for subcohorts in specialized facilities. 248
C.1.5 Cluster Berlin-Brandenburg 249 C.1 Annex: Description of the study centers The Cluster Berlin-Brandenburg consists of the Max Delbrueck Center for Molecular Medicine (MDC), the Charité – University Medical Center Berlin, the German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), and the Robert Koch Institute (RKI). The Cluster comprises three study centers that are located at or near the sites of the partner institutions (Berlin-North, located in the northern part of Berlin; Berlin-Center, located in the central part of Berlin; and Berlin-South, located in the southern part of Berlin). They are spread across the study region, the metropolitan area of Berlin-Brandenburg, thereby minimizing costs and time for study participants to travel to the centers and increasing their willingness to participate. Within a radius of 60 km, these study centers cover a total source population of 4.4 million inhabitants (3.4 million in Berlin and 1.0 million in the adjacent districts of Brandenburg). figure 5: Geographical overview of recruitment areas and study centers for the cluster Berlin- Brandenburg Berlin–Brandenburg MDC Charité DIfE RKI SC Berlin-North SC Berlin-Center SC Berlin-South/ Brandenburg Study center (SC) Coordinating institution Participating institution Recruitment areas: Berlin city Adjacent suburban municipalities in Brandenburg MDC Berlin C.1
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The National Cohort A prospective e
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Applicants Applicants Applicants Cl
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Applicants IV
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Executive Summary 2. The National C
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Executive Summary 3. Scientific aim
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Executive Summary essary to address
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Executive Summary 7. Examples for s
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Contents A.2.4 major areas of expos
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Contents A.3.8.2 Social security da
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Contents A.6.4.2 Minimally detectab
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Abbreviations C.2 mEThOdS fOr STATI
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Abbreviations DXA Dual-energy x-ray
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Abbreviations CHS Cardiovascular He
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A.1 A.1 Introduction and overview a
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A.3 A.3 Study design ment instrumen
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A.3 A.3 Study design the participan
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A.3 A.3 Study design ovarian carcin
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A.3 A.3 Study design depression and
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A.3 A.3 Study design to the extent
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A.3 A.3 Study design ticipants and
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A.3 A.3 Study design index, convent
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A.3 A.3 Study design diseases in va
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A.3 A.3 Study design study. For exa
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