Scientific Concept of the National Cohort (status ... - Nationale Kohorte

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C.1 C.1 Annex: Description of the study centers Description of the study center Hamburg At the University Medical Center Hamburg, 10,000 individuals will be recruited. The center is located close to the city center of Hamburg. It is directly connected via two bus lines operating every 5 min and the underground is nearby. A central garage is available directly beneath the building. The study center is a separate building on the campus of the university medical center. It comprises rooms for reception, investigations, interviews and preanalytical preparation and interim storage of biosamples (in total covering about 400 m²). The Department of Radiology for possible MRI examinations is located directly on the opposite side. Table 1: Overview of participating institutions and investigators/scientists Study center Bremen Table 23: Overview of participating institutions and investigators/scientists Institution Town Principal investigator Institute/department/division e-mail Co-principal investigator Institute/department/division e-mail Associated scientist Institute/department/division e-mail Institution Town Associated scientist Institute/department/division e-mail Associated scientist Institute/department/division e-mail Bremen Institute of Prevention Research and Social Medicine (BIPS) 28359 Bremen Prof. Dr. Wolfgang Ahrens Department of Epidemiologic Methods and Etiologic Research ahrens@bips.uni-bremen.de PD Dr. Thomas Behrens Department of Epidemiologic Methods and Etiologic Research behrens@bips.uni-bremen.de Stefanie Dreger Department of Epidemiologic Methods and Etiologic Research dreger@bips.uni-bremen.de Georg-August-University Goettingen, Medical School 37073 Goettingen Prof. Dr. Heike Bickeböller Department of Genetic Epidemiology, Center for Informatics, Statistics and Epidemiology hbickeb@gwdg.de Prof. Dr. Peter Falkai Department of Psychiatry and Psychotherapy pfalkai@gwdg.de 260
261 C.1 Annex: Description of the study centers Description of the institutions responsible for establishing and operating the study center The Bremen Institute for Prevention research and Social medicine (BIPS) was established on January 1, 1981, and joined the University of Bremen as a central research unit in 2007. On November 28, 2009 BIPS became an associated member of the Research Community Gottfried Wilhelm Leibniz e.V. (Leibniz Community). As an epidemiologic research institute BIPS covers the entire spectrum of epidemiologic research, including the description of health and health-related factors in populations, identification of determinants of health and disease, and implementation and evaluation of health interventions and the associated transfer of results to politics and citizens. For that purpose employees from various fields and qualifications are cooperating within the institute. The staff at BIPS comprises 44 scientists, 48 nonscientists and 35 student assistants who are working in four departments. The BIPS has long-standing experience in coordinating and executing large population-based cohort studies within national and international cooperations. The ongoing IDEFICS study (”Identification and prevention of dietary- and lifestyle-induced health effects in children and infants”) was set up in 11 countries across Europe and is currently being coordinated by BIPS. The study is following the health status of approx. 16,000 2- to 9-year-old children. Furthermore, BIPS has coordinated the external quality control of field work and organized and coordinated the central field work training for all 16 study centers. Several studies with mortality follow-up have been conducted at BIPS. To obtain information on causes of death from death certificates, standard data protection procedures have been developed and applied in various studies, e.g., in the BIPS Bitumen Cohort Study. Procedures also comprise identification of next-to-kin subjects. The epidemiologic cancer registry of the State of Bremen is located at BIPS. It is complemented by the Bremen death index (Bremen Mortality Index, BreMI) for the State of Bremen, which registers the cause of death and all information from the death certificate of all Bremen residents since 01.01.1998 in an electronic database. The information in the BreMI database can be personally linked with subjects in a cohort study to establish the cause of death for cohort members residing in Bremen. According to §9, Abs. 6 Nr. 2 Gesetz des Leichenwesens, the BREMI may be used for public research projects. In addition, BIPS hosts a pharmacoepidemiologic database covering 14 mill. members (or roughly 1/6 of the entire German population) enrolled in four Statutory Health Insurances (SHIs). About 85% of the total population in Germany is registered as member of one of these SHIs. In its long standing experience in coordinating and conducting large national and international population-based studies, BIPS has acquired special expertise in biosample quality management and biosample logistics (shipping, storage and electronic documentation of samples). BIPS has an experienced data management unit that develops tools for the implementation of studies and surveys. A set of routines and procedures for data management, questionnaires for computer-assisted interviewing, and a study management system to operate and supervise data assessment are under continuous development. These tools are also employed outside the institute in multicentric, international studies. A special software tool to control compliance with standard contact procedures and to monitor follow-up of study participants has been designed to standardize all field procedures, increase response proportion, and facilitate quality assurance of contact procedures. This electronic contact documentation records all attempted contacts with study participants, including their outcome (interview completed, agreed to interview, agreement pending, or interview refused). The data management unit has experience in setting and supporting large and complex databases. C.1
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The National Cohort A prospective e
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Applicants Applicants Applicants Cl
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Applicants IV
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Executive Summary 2. The National C
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Executive Summary 3. Scientific aim
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Executive Summary essary to address
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Executive Summary 7. Examples for s
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Contents A.2.4 major areas of expos
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Contents A.3.8.2 Social security da
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Contents A.6.4.2 Minimally detectab
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Abbreviations C.2 mEThOdS fOr STATI
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Abbreviations DXA Dual-energy x-ray
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Abbreviations CHS Cardiovascular He
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A.1 A.1 Introduction and overview a
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A.2 A.2. Scientific background and
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A.3 A.3 Study design ment instrumen
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A.3 A.3 Study design the participan
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A.3 A.3 Study design A.3.2 Baseline
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A.3 A.3 Study design Modules 70 Int
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A.3 A.3 Study design ovarian carcin
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A.3 A.3 Study design depression and
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A.3 A.3 Study design to the extent
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A.3 A.3 Study design ers to vaccina
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A.3 A.3 Study design certain foods)
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A.3 A.3 Study design A short instru
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A.3 A.3 Study design ticipants and
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A.3 A.3 Study design a resting time
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A.3 A.3 Study design index, convent
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A.3 A.3 Study design genetics of BM
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A.3 A.3 Study design Project title
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A.3 A.3 Study design diseases in va
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A.3 A.3 Study design associations,
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A.3 A.3 Study design Informed Conse
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A.3 A.3 Study design 6. Since being
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A.3 A.3 Study design the possible d
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A.3 A.3 Study design A.3.5 Collecti
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A.3 A.3 Study design Blood In addit
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A.3 A.3 Study design the anterior n
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A.3 A.3 Study design study. For exa
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A.3 A.3 Study design routinely prep
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A.3 A.3 Study design A.3.6.3 reliab
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A.3 A.3 Study design In addition, a
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A.3 A.3 Study design Disease Questi
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A.3 A.3 Study design Data routinely
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A.3 A.3 Study design tial misclassi
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A.3 A.3 Study design � The KORA c
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