Scientific Concept of the National Cohort (status ... - Nationale Kohorte

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C.1 C.1 Annex: Description of the study centers The study center has rooms for clinical investigations, computer-assisted interviews, and preanalytical preparation and interim storage of biosamples (in total covering about 210 m²). The close cooperation with the Comprehensive Cancer Center in Essen, which is located at the University Hospital, ensures the efficient tracing of incident cancer cases. The close vicinity to the Medical Faculty in Essen facilitates close cooperation with clinicians and associated scientists from the faculty of Medicine. The Robert-Koch-Erhebungszentrum is regularly certified and re-certified according to quality management procedures of DIN ISO 9001:2001/2008. figure 1: An ongoing examination at the Robert-Koch-Erhebungszentrum in Essen Table 1: Overview of participating institutions and investigators/scientists Study center Muenster Table 10: Overview of participating institutions and investigators/scientists Institution Town Principal investigator Institute/department/division e-mail Co-principal investigator Institute/department/division e-mail University of Muenster 48149 Muenster Prof. Dr. Klaus Berger, MPH, MSc Institute of Epidemiology and Social Medicine bergerk@uni-muenster.de Prof. Dr. Hans-Werner Hense Institute of Epidemiology and Social Medicine hense@uni-muenster.de 242
243 C.1 Annex: Description of the study centers Description of the institution responsible for establishing and operating the study center The Institute of Epidemiology and Social Medicine is part of the medical faculty of the University of Muenster and located on the campus of the niversity hospital. It has been a WHO Collaborating Center for epidemiology and prevention of cardiovascular and other chronic diseases since 2000. A wide range of both population based and patient register based epidemiologic studies has been successfully performed by the institute. Experienced staff trained in data collection (interviews, examination, and medical information), and recruitment procedures (documentaries) is available. A close collaboration (in person) has been established with the Cancer Registry of North Rhine-Westfalia. Several ongoing epidemiologic studies are being led by members of the institute, in the fields of neurologic and psychiatric epidemiology, aging, cardiovascular epidemiology, and cancer. The institute will run the study center Muenster, coordinated by K. Berger and H.W. Hense. Description of the study center Muenster The Muenster area (county) includes a population of 2.6 million, of which 259,000 inhabitants live in the city of Muenster. The sampling frame will be the city and surrounding communities, which includes both urban and rural areas. At this site 10,000 participants will be recruited. The study center will be located in the city of Muenster with good accessibility for the study participants of the region. It will comprise rooms for investigation, interviews, and preanalytical preparation and interim storage of biosamples. Table 1: Overview of participating institutions and investigators/scientists Study center Duesseldorf Table 11: Overview of participating institutions and investigators/scientists Institution Town Principal investigator Institute/department/division e-mail Institution Town Co-principal investigator Institute/department/division e-mail Institution Town Associated scientist Institute/department/division e-mail German Diabetes Center (DDZ) 40225 Duesseldorf Prof. Dr. Guido Giani Institute of Biometrics and Epidemiology giani@ddz.uni-duesseldorf.de IUF - Leibniz Research Institute for Environmental Medicine 40225 Duesseldorf Prof. Dr. Ursula Krämer Division of Epidemiology kraemeru@uni-duesseldorf.de German Diabetes Center (DDZ) 40225 Duesseldorf Prof. Dr. med. Michael Roden Institute of Clinical Diabetology michael.roden@ddz.uni-duesseldorf.de C.1
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The National Cohort A prospective e
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Applicants Applicants Applicants Cl
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Applicants IV
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Executive Summary 2. The National C
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Executive Summary 3. Scientific aim
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Executive Summary essary to address
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Executive Summary 7. Examples for s
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Contents A.2.4 major areas of expos
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Contents A.3.8.2 Social security da
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Contents A.6.4.2 Minimally detectab
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Abbreviations C.2 mEThOdS fOr STATI
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Abbreviations DXA Dual-energy x-ray
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Abbreviations CHS Cardiovascular He
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A.1 A.1 Introduction and overview a
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A.1 A.1 Introduction and overview s
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A.2 A.2. Scientific background and
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A.3 A.3 Study design ment instrumen
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A.3 A.3 Study design Table 3.2: Des
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A.3 A.3 Study design Table 3.3: Dis
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A.3 A.3 Study design the participan
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A.3 A.3 Study design with a prepare
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A.3 A.3 Study design rural areas, t
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A.3 A.3 Study design A.3.2 Baseline
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A.3 A.3 Study design Modules 70 Int
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A.3 A.3 Study design ovarian carcin
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A.3 A.3 Study design Table 3.5: Spe
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A.3 A.3 Study design depression and
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A.3 A.3 Study design to the extent
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A.3 A.3 Study design ers to vaccina
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A.3 A.3 Study design certain foods)
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A.3 A.3 Study design A short instru
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A.3 A.3 Study design ticipants and
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A.3 A.3 Study design a resting time
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A.3 A.3 Study design index, convent
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A.3 A.3 Study design Although the i
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A.3 A.3 Study design hemorrhages (0
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A.3 A.3 Study design genetics of BM
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A.3 A.3 Study design hand grip stre
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A.3 A.3 Study design Project title
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A.3 A.3 Study design diseases in va
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A.3 A.3 Study design associations,
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A.3 A.3 Study design Informed Conse
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A.3 A.3 Study design 6. Since being
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A.3 A.3 Study design the possible d
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A.3 A.3 Study design A.3.5 Collecti
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A.3 A.3 Study design Blood In addit
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A.3 A.3 Study design the anterior n
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A.3 A.3 Study design study. For exa
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A.3 A.3 Study design large-size sto
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A.3 A.3 Study design routinely prep
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A.3 A.3 Study design Subjects who m
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A.3 A.3 Study design A.3.6.3 reliab
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A.3 A.3 Study design In addition, a
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A.3 A.3 Study design Disease Questi
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A.3 A.3 Study design Data routinely
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A.3 A.3 Study design tial misclassi
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A.3 A.3 Study design � The KORA c
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A.4 A.4 Integrated Data Management
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A.5 A.5 Methods for quality assuran
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A.6 A.6 Planned statistical analyse
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C.3 References 360. Mair, C., A.V.
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C.3 References 431. Statistisches B
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C.3 References 462. Bundeszentrale
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