Scientific Concept of the National Cohort (status ... - Nationale Kohorte

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C.1 C.1 Annex: Description of the study centers In addition, BIPS has a long-standing experience in quality assurance of population-based cohort studies. BIPS has coordinated the evaluation of the German Cardiovascular Prevention Study (DHP) and the Southern German Nasal Cell Carcinoma study and implemented various control measures regarding survey quality. BIPS also held the exclusive responsibility for quality control of the second and third survey of the DHP. Moreover, the institute is in charge of external quality control for the ‘Deutsche Erwachsenen Gesundheitssurvey’ (DEGS) conducted by the Robert-Koch-Institute (RKI) in 180 examination centers across Germany (N=7,500). H. Bickeböller and P. Falkai from the University Medical School of the Georg-August-University Goettingen (Universitätsmedizin Goettingen, UMG) will contribute their scientific experience and will harmonize their Neuro Chort Goettingen (n=3,000) with the protocol of the National cohort (see Outlook). H. Bickeböller from the Department of Genetic Epidemiology has long standing experience in epidemiological studies with a genetic focus. P Falkai from the section on Psychiatric Genetics has longstanding experience in the establishment and extensive phenotype characterization of large cohorts of patients and controls for psychiatric genetic epidemiological studies. The department of Epidemiologic methods and Etiological research integrates core areas of epidemiologic research in occupational, environmental, and lifestyle epidemiology. The increasing need to investigate the interplay of complex exposures of the modern environment and to overcome difficulties regarding validation and quantification of these exposures requires both sophisticated statistical methods as well as considerable efforts in exposure assessment. BIPS will head the study center Bremen coordinated by W. Ahrens. Description of the study center Bremen In Bremen and the surrounding area, 10,000 study participants will be recruited. The study center will be located on the ground floor of the BIPS. Accessibility to the study center is very good since a tram stop is located right in front of the building. The trip from the central station to the study center takes ca. 10 min. The study center is equipped with four rooms for physical examinations, and interviews, and a laboratory for preanalytical preparation (in total ca. 200 m²), plus rooms for storaging biosamples. Currently, there is a cold storage room (35 m³) where biosamples are kept at –20 ºC, 22 freezers (–20 ºC), and 14 ultra deep freezers (–80 ºC). BIPS has a special unit „field work“ that conducts and supervises the recruitment of study participants. The unit has long-standing experience in adopting and evaluating standardized survey instruments and in recruiting and following up study participants. The close collaboration with the cancer registry of Bremen, which is located at BIPS, ensures an efficient tracing of incident cancer cases. The Center for advanced imaging (CAI) at Bremen University is one of five outstanding regional imaging centers in Germany to be designated a “Center of Excellence” (http://www. med.uni-magdeburg.de/cai/einfuhrung.html). It has expertise in developing new neuroimaging and visualization techniques. CAI has extensive brain-imaging laboratories at its disposal. These laboratories are equipped with MRI units for the functional and spectroscopic examination of human subjects (1.5 T, 3x3 T, and 7 T), animals, and tissues (2x4.7 T, 2x8.4 T, and 14.1 T). It also has a whole-head MEG apparatus with integrated EEG (248/96 channels). In addition, the Fraunhofer MEVIS - Institute for Medical Image Computing is located in the neighbouring building of the BIPS. Fraunhofer MEVIS is one of the leading global and internationally networked research and development centers for computer assistance in image-based medicine. It follows a patient-centered and workflow-oriented approach to resolve clinically relevant issues in image-based diagnosis and therapy. Fraunhofer MEVIS focuses on epidemiologically significant diseases of the cardiovascular system, the brain, liver and lung, as well as oncological disorders (www.mevis.fraunhofer.de/en/Institute.html). 262
C.1.7 Cluster Schleswig-holstein 263 C.1 Annex: Description of the study centers The Cluster Schleswig-Holstein comprises one study center in the area of Schleswig-Hol- Recruitment cluster stein, located in Kiel. figure 7: Geographical overview of recruitment areas and study centers for the cluster Schleswig- Holstein Schleswig-Holstein Study center (SC) Coordinating institution Participating institution Recruitment areas: SC Kiel University Kiel University Luebeck Kiel city County of Rendsburg-Eckernfoerde Kiel C.1
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The National Cohort A prospective e
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Applicants Applicants Applicants Cl
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Applicants IV
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Executive Summary 2. The National C
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Executive Summary 3. Scientific aim
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Executive Summary essary to address
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Executive Summary 7. Examples for s
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Contents A.2.4 major areas of expos
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Contents A.3.8.2 Social security da
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Contents A.6.4.2 Minimally detectab
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Abbreviations C.2 mEThOdS fOr STATI
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Abbreviations DXA Dual-energy x-ray
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Abbreviations CHS Cardiovascular He
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A.1 A.1 Introduction and overview a
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A.1 A.1 Introduction and overview s
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A.2 A.2. Scientific background and
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A.3 A.3 Study design ment instrumen
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A.3 A.3 Study design Table 3.2: Des
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A.3 A.3 Study design the participan
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A.3 A.3 Study design with a prepare
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A.3 A.3 Study design A.3.2 Baseline
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A.3 A.3 Study design Modules 70 Int
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A.3 A.3 Study design ovarian carcin
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A.3 A.3 Study design Table 3.5: Spe
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A.3 A.3 Study design depression and
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A.3 A.3 Study design to the extent
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A.3 A.3 Study design ers to vaccina
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A.3 A.3 Study design certain foods)
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A.3 A.3 Study design A short instru
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A.3 A.3 Study design ticipants and
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A.3 A.3 Study design a resting time
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A.3 A.3 Study design index, convent
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A.3 A.3 Study design hemorrhages (0
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A.3 A.3 Study design genetics of BM
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A.3 A.3 Study design Project title
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A.3 A.3 Study design diseases in va
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A.3 A.3 Study design associations,
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A.3 A.3 Study design Informed Conse
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A.3 A.3 Study design 6. Since being
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A.3 A.3 Study design the possible d
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A.3 A.3 Study design A.3.5 Collecti
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A.3 A.3 Study design Blood In addit
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A.3 A.3 Study design the anterior n
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A.3 A.3 Study design study. For exa
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A.3 A.3 Study design large-size sto
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A.3 A.3 Study design routinely prep
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A.3 A.3 Study design Subjects who m
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A.3 A.3 Study design A.3.6.3 reliab
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A.3 A.3 Study design In addition, a
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A.3 A.3 Study design Disease Questi
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A.3 A.3 Study design Data routinely
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A.3 A.3 Study design � The KORA c
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A.4 A.4 Integrated Data Management
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A.7 A.7 Ethical aspects logical/gen
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C.3 References 431. Statistisches B
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C.3 References 462. Bundeszentrale
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