Scientific Concept of the National Cohort (status ... - Nationale Kohorte

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Applicants IV
Executive Summary V Executive Summary 1. The National Cohort – A prospective epidemiologic study resource for health and disease research in Germany Since early 2007, a growing network of German research institutions has jointly been developing plans for a large prospective cohort that should be used as a common, national resource for studies on the risk factors and etiologic mechanisms of major diseases in the German population. The institutions include several of the publically funded Helmholtz institutes, a large number of universities, and other non-Helmholtz public research institutions. A first outline of these plans was formally evaluated in April 2008 by an international review panel, in the context of a five-yearly scientific peer review of the Helmholtz Association. For the biomedical Helmholtz institutes, coordinated by the German Cancer Research Center [DKFZ] and Helmholtz Research Center München [HMGU], start-up funds at the level of 20 Mio Euro for the period 2009-2013 have been provided. To include the expertise from universities and non-Helmholtz public research institutions as from the earliest planning phase, a national Epidemiological Planning Committee (“EPC”) was established in February 2009 with representatives from the biomedical Helmholtz institutions, the universities, two public research center (Robert Koch Institute [“RKI”] Berlin and the German Institute for Nutrition Research ([“DIfE”], Potsdam) and the three German medical scientific societies primarily engaged in epidemiology. It was decided that the National Cohort should have three major goals: (i) to serve as a research platform for future epidemiologic population-based research in Germany, (ii) to make valuable contributions to answer innovative research questions in the field of epidemiology, basic science, and their intersection and (iii) to cooperate internationally with other large-scale prospective studies. As many epidemiologic research institutions had expressed their interest in participatig in subject recruitment for the cohort, in autumn 2009 a formal call for tender was published and international peer review of the applications was organized. The selection of partner centers was based on a pre-defined qualification profile. During the application process, the applicant centers formed regional clusters for scientific and logistic cooperation. The review led to the selection of 24 research institutions, in total, including 14 Universities, 5 Helmholtz Research Centers, three Leibniz centers, and the Robert-Koch-Institute that met the qualification criteria for taking part in cohort recruitment. Under the auspices of the EPC, a total of 17 thematic working groups* were established early in 2009 to identify the most challenging research questions to be addressed with the National Cohort, and to discuss questions of study design and content. These working groups involved over 200 scientists (among them also many clinical scientists) and covered the major disease areas, as well as a number of specific topics related to risk factor assessment and study logistics. By December 2009, each of the thematic working groups prepared a report with proposals for specific topics to be studied, and recommendations for instruments to be used for data collection or medical examinations. These reports provided the basis of the scientific protocol that is described in part A of the present research application, and that was developed in 2010 by a series of writing teams guided by a small editorial board of EPC members. * Reports of the thematic working groups can be found on the CD ROM.
Page 1: The National Cohort A prospective e
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A.3 A.3 Study design the participan
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A.3 A.3 Study design depression and
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A.3 A.3 Study design to the extent
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A.3 A.3 Study design ers to vaccina
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A.3 A.3 Study design certain foods)
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A.3 A.3 Study design A short instru
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A.3 A.3 Study design ticipants and
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A.3 A.3 Study design a resting time
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A.3 A.3 Study design index, convent
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A.3 A.3 Study design Informed Conse
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A.3 A.3 Study design 6. Since being
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A.3 A.3 Study design A.3.5 Collecti
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A.3 A.3 Study design Blood In addit
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A.3 A.3 Study design study. For exa
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A.3 A.3 Study design large-size sto
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A.3 A.3 Study design routinely prep
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A.3 A.3 Study design In addition, a
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A.3 A.3 Study design Disease Questi
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A.4 A.4 Integrated Data Management
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C.3 References 17. Keil, U., et al.
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