Scientific Concept of the National Cohort (status ... - Nationale Kohorte

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C.2 Table S6.5: Sample size needed for detection of a given standardized difference A (statistical power 0.08, significance level 0.05) by number of Table controls S6.5: per Sample cases. size needed for detection of a given standardized difference A (statistical power 0.80, significance level 0.05) by number of controls per cases. C.2 Annex: Methods for Statistical Power and Sample Size Calculations Sample size 0.05 0.08 0.10 0.15 0.20 0.25 0.30 0.35 0.40 Variance inflation factor correlation (ρ 2 CE) Critical p-value Case to control ratio (unmatched) (VIF) 1:1 0.05 No adjustment 6280 2455 1572 700 395 253 177 130 100 0.05 0.3 1.10 6908 2701 1729 770 435 278 195 143 110 0.05 0.5 1.33 9188 3592 2300 1024 578 370 259 190 146 0.05 0.7 1.96 18008 7040 4508 2007 1133 725 508 373 287 10 -4 No adjustment 17921 7004 4485 1997 1126 723 504 372 286 0.3 1.10 19713 7704 4934 2197 1239 795 554 409 315 10 -4 0.5 1.33 26218 10247 6562 2922 1647 1058 737 544 418 10 -4 0.7 1.96 51388 20084 12861 5726 3229 2073 1445 1067 820 10 -4 1:2 0.05 No adjustment 4711 1841 1179 525 296 190 132 98 75 0.05 0.3 1.10 5182 2025 1297 578 326 209 145 108 83 278 0.05 0.5 1.33 6892 2693 1725 768 433 278 193 143 110 0.05 0.7 1.96 13509 5279 3381 1505 849 545 379 281 215 10 -4 No adjustment 13440 5253 3363 1497 844 542 377 278 241 0.3 1.10 14784 5778 3699 1647 928 596 415 306 265 10 -4 0.5 1.33 19663 7685 4920 2190 1235 793 552 407 353 10 -4 0.7 1.96 38539 15063 9643 4293 2420 1554 1081 797 691 10 -4 1:4 0.05 No adjustment 3925 1534 982 437 246 158 110 81 62 0.05 0.3 1.10 4318 1687 1080 481 271 174 121 89 68 0.05 0.5 1.33 5742 2244 1437 639 360 231 161 119 91 0.05 0.7 1.96 11255 4399 2816 1253 705 453 315 232 178 10 -4 No adjustment 11199 4376 2802 1247 702 450 314 231 178 0.3 1.10 12319 4814 3082 1372 772 495 345 254 196 10 -4 0.5 1.33 16384 6402 4099 1824 1027 658 459 338 260 10 -4 0.7 1.96 32113 12548 8035 3576 2013 1290 900 662 510 10 -4
Table S6.6a: Minimum detectable odds ratios (MDOR; statistical power 0.80 at significance level of either 0.05 or 10-4) for a genetic main effect, by allele frequency; nested case-control study with 2 controls per case. Minimum detectable OR for genetic effect (2 controls) 10 000 cases 5000 cases 4000 cases 3000 cases 500 700 1000 1500 2000 2500 Minimum detectable OR for genetic effect (2 controls) cases cases cases cases cases cases 400 cases 300 cases 200 cases 150 cases Critical pvalue Allele frequency C.2 Annex: Methods for Statistical Power and Sample Size Calculations 0.05 0.05 2.2 2.0 1.8 1.7 1.6 1.5 1.4 1.3 1.3 1.2 1.2 1.2 1.18 1.12 0.05 10 -4 3.5 3.0 2.6 2.3 2.1 1.9 1.7 1.6 1.5 1.4 1.4 1.3 1.3 1.2 0.1 0.05 1.9 1.8 1.6 1.5 1.5 1.4 1.3 1.3 1.2 1.19 1.17 1.15 1.13 1.10 0.1 10 -4 2.9 2.5 2.2 2.0 1.8 1.7 1.6 1.4 1.4 1.3 1.3 1.3 1.2 1.16 0.25 0.05 1.8 1.6 1.5 1.4 1.4 1.3 1.3 1.2 1.17 1.15 1.14 1.12 1.11 1.08 0.25 10 -4 2.6 2.3 2.0 1.8 1.7 1.6 1.5 1.4 1.3 1.3 1.2 1.2 1.18 1.13 0.5 0.05 2.1 1.9 1.6 1.5 1.5 1.4 1.3 1.2 1.2 1.18 1.16 1.14 1.13 1.09 0.5 10 -4 150 200 300 400 500 700 1000 1500 2000 2500 3000 4000 5000 10 000 cases cases cases cases cases cases cases cases cases cases cases cases cases cases 0.05 0.05 2.2 2.0 1.8 1.7 1.6 1.5 1.4 1.3 1.3 1.2 1.2 1.2 1.18 1.12 0.05 10 3.9 3.2 2.5 2.1 2.0 1.7 1.6 1.5 1.4 1.3 1.3 1.3 1.2 1.15 * highlighted are the combinations where MDOR is 1.5 or smaller Minimum detectable OR for genetic effect (4 controls) 150 200 300 400 500 700 1000 1500 2000 2500 3000 4000 5000 10 000 cases cases cases cases cases cases cases cases cases cases cases cases cases cases -4 3.5 3.0 2.6 2.3 2.1 1.9 1.7 1.6 1.5 1.4 1.4 1.3 1.3 1.2 0.1 0.05 1.9 1.8 1.6 1.5 1.5 1.4 1.3 1.3 1.2 1.19 1.17 1.15 1.13 1.10 0.1 10 -4 2.9 2.5 2.2 2.0 1.8 1.7 1.6 1.4 1.4 1.3 1.3 1.3 1.2 1.16 0.25 0.05 1.8 1.6 1.5 1.4 1.4 1.3 1.3 1.2 1.17 1.15 1.14 1.12 1.11 1.08 0.25 10 -4 2.6 2.3 2.0 1.8 1.7 1.6 1.5 1.4 1.3 1.3 1.2 1.2 1.18 1.13 0.5 0.05 2.1 1.9 1.6 1.5 1.5 1.4 1.3 1.2 1.2 1.18 1.16 1.14 1.13 1.09 0.5 10 -4 Table S6.6b: Minimum 3.9 detectable 3.2 odds 2.5 ratios 2.1 (MDOR; 2.0 statistical 1.7 power 0.80, 1.6 at significance 1.5 1.4 level of either 1.3 0.05 1.3 or 10-4) 1.3 for a genetic 1.2 main 1.15 effect, * by highlighted allele frequency; are the combinations nested case-control where MDOR study is 1.5 with or 4 smaller controls per case Minimum detectable OR for genetic effect (4 controls) Critical pvalue Allele frequency 279 Critical pvalue Allele frequency 0.05 0.05 2.0 1.9 1.7 1.6 1.5 1.5 1.4 1.3 1.3 1.2 1.2 1.18 1.16 1.11 0.05 10 -4 3.2 2.8 2.4 2.1 2.0 1.8 1.7 1.5 1.5 1.4 1.4 1.3 1.3 1.2 0.1 0.05 1.8 1.7 1.5 1.5 1.4 1.3 1.3 1.2 1.19 1.17 1.16 1.14 1.12 1.09 0.1 10 -4 2.6 2.3 2.0 1.9 1.7 1.6 1.5 1.4 1.3 1.3 1.3 1.2 1.2 1.15 0.25 0.05 1.7 1.6 1.4 1.4 1.3 1.3 1.2 1.19 1.16 1.14 1.13 1.11 1.10 1.07 0.25 10 -4 2.4 2.1 1.9 1.7 1.6 1.5 1.4 1.3 1.3 1.2 1.2 1.19 1.17 1.12 0.5 0.05 1.9 1.8 1.6 1.5 1.4 1.3 1.3 1.2 1.19 1.16 1.15 1.13 1.11 1.08 0.5 10 -4 150 200 300 400 500 700 1000 1500 2000 2500 3000 4000 5000 10 000 cases cases cases cases cases cases cases cases cases cases cases cases cases cases 0.05 0.05 2.0 1.9 1.7 1.6 1.5 1.5 1.4 1.3 1.3 1.2 1.2 1.18 1.16 1.11 0.05 10 3.5 2.8 2.3 2.0 1.8 1.7 1.5 1.4 1.3 1.3 1.3 1.2 1.2 1.14 * highlighted are the combinations where MDOR is 1.5 or smaller -4 3.2 2.8 2.4 2.1 2.0 1.8 1.7 1.5 1.5 1.4 1.4 1.3 1.3 1.2 0.1 0.05 1.8 1.7 1.5 1.5 1.4 1.3 1.3 1.2 1.19 1.17 1.16 1.14 1.12 1.09 0.1 10 -4 2.6 2.3 2.0 1.9 1.7 1.6 1.5 1.4 1.3 1.3 1.3 1.2 1.2 1.15 0.25 0.05 1.7 1.6 1.4 1.4 1.3 1.3 1.2 1.19 1.16 1.14 1.13 1.11 1.10 1.07 0.25 10 -4 2.4 2.1 1.9 1.7 1.6 1.5 1.4 1.3 1.3 1.2 1.2 1.19 1.17 1.12 0.5 0.05 1.9 1.8 1.6 1.5 1.4 1.3 1.3 1.2 1.19 1.16 1.15 1.13 1.11 1.08 0.5 10 -4 3.5 2.8 2.3 2.0 1.8 1.7 1.5 1.4 1.3 1.3 1.3 1.2 1.2 1.14 Critical pvalue Allele frequency * highlighted are the combinations where MDOR is 1.5 or smaller C.2
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The National Cohort A prospective e
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Applicants Applicants Applicants Cl
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Applicants IV
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Executive Summary 2. The National C
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Executive Summary 3. Scientific aim
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Executive Summary essary to address
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Executive Summary 7. Examples for s
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Contents A.2.4 major areas of expos
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Contents A.3.8.2 Social security da
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Contents A.6.4.2 Minimally detectab
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Abbreviations C.2 mEThOdS fOr STATI
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Abbreviations DXA Dual-energy x-ray
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Abbreviations CHS Cardiovascular He
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A.1 A.1 Introduction and overview a
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A.1 A.1 Introduction and overview s
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A.3 A.3 Study design ment instrumen
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A.3 A.3 Study design diseases in va
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A.3 A.3 Study design A.3.5 Collecti
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A.3 A.3 Study design routinely prep
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A.3 A.3 Study design Disease Questi
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A.3 A.3 Study design tial misclassi
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A.6 A.6 Planned statistical analyse
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A.7 A.7 Ethical aspects logical/gen
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A.7 A.7 Ethical aspects Data handli
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A.7 Table 7.2 Availability of ident
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A.7 A.7 Ethical aspects ing finding
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C.1 C.1 Annex: Description of the s
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