Scientific Concept of the National Cohort (status ... - Nationale Kohorte

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Executive Summary 7. Examples for specific research questions To illustrate the scientific potential of the National Cohort, Table 1.1 of our main application text (Sect. A.1.4) lists 37 examples of specific research questions related to major disease outcomes that will be addressed by the National Cohort in ways that are not possible with currently ongoing prospective studies in Germany. XII
Contents XIII Contents A.1 INTrOduCTION ANd OvErvIEw .................................................................. 1 A.1.1 Societal and economic burden of chronic disease in Germany .............. 1 A.1.2 Prospective cohorts as an indispensable tool for health research ........ 1 A.1.3 The National Cohort: Overview of study design ....................................... 2 A.1.4 Scientific aims of the National Cohort ........................................................ 6 A.1.5 Arguments for a large cohort in Germany ............................................... 12 A.1.6 Justification of sample size requirements ............................................... 15 A.1.7 Outlook: The National Cohort as basis for collaborations and further research projects ................................................................... 16 A.1.8 Preparatory work for the National Cohort ................................................ 19 A.2 SCIENTIfIC BACkGrOuNd ANd rATIONAlE fOr STudy ElEmENTS ........................................................................................................ 21 A.2.1 Introduction ................................................................................................. 21 A.2.2 major disease outcomes of core focus .................................................... 23 A.2.2.1 Cardiovascular diseases ............................................................... 24 A.2.2.2 Diabetes mellitus .......................................................................... 26 A.2.2.3 Cancer ........................................................................................... 27 A.2.2.4 Neurologic and psychiatric diseases .............................................. 28 A.2.2.5 Respiratory diseases ..................................................................... 32 A.2.2.6 Infectious diseases ........................................................................ 33 A.2.3 Intermediate (preclinical) phenotypes and function measurements ... 35 A.2.3.1 Cardiovascular functions and preclinical phenotypes ..................... 35 A.2.3.2 Diabetes-related functional measurements and preclinical phenotypes ................................................................... 36 A.2.3.3 Cancer-related precursor stages ................................................... 38 A.2.3.4 Intermediate stages of neurologic and psychiatric diseases .......... 39 A.2.3.5 Respiratory function and preclinical phenotype ............................. 39 A.2.3.6 Musculoskeletal functions and phenotypes .................................... 40
Page 1: The National Cohort A prospective e
Page 4 and 5: Applicants Applicants Applicants Cl
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Page 8 and 9: Executive Summary 2. The National C
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A.3 A.3 Study design ment instrumen
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A.3 A.3 Study design the participan
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A.3 A.3 Study design with a prepare
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A.3 A.3 Study design rural areas, t
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A.3 A.3 Study design A.3.2 Baseline
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A.3 A.3 Study design Modules 70 Int
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A.3 A.3 Study design ovarian carcin
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A.3 A.3 Study design depression and
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A.3 A.3 Study design to the extent
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A.3 A.3 Study design ers to vaccina
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A.3 A.3 Study design certain foods)
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A.3 A.3 Study design A short instru
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A.3 A.3 Study design ticipants and
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A.3 A.3 Study design a resting time
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A.3 A.3 Study design index, convent
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A.3 A.3 Study design Although the i
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A.3 A.3 Study design hemorrhages (0
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A.3 A.3 Study design genetics of BM
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A.3 A.3 Study design Project title
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A.3 A.3 Study design diseases in va
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A.3 A.3 Study design associations,
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A.3 A.3 Study design Informed Conse
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A.3 A.3 Study design 6. Since being
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A.3 A.3 Study design the possible d
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A.3 A.3 Study design A.3.5 Collecti
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A.3 A.3 Study design Blood In addit
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A.3 A.3 Study design the anterior n
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A.3 A.3 Study design study. For exa
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A.3 A.3 Study design large-size sto
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A.3 A.3 Study design routinely prep
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A.3 A.3 Study design Subjects who m
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A.3 A.3 Study design A.3.6.3 reliab
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A.3 A.3 Study design In addition, a
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A.3 A.3 Study design Disease Questi
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A.3 A.3 Study design Data routinely
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A.3 A.3 Study design tial misclassi
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A.3 A.3 Study design � The KORA c
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A.4 A.4 Integrated Data Management
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A.5 A.5 Methods for quality assuran
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A.6 A.6 Planned statistical analyse
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A.6 A.6 Table Planned 6.4: Expected
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A.6 Planned statistical analyses an
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A.7 A.7 Ethical aspects logical/gen
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C.2 Table S6.5: Sample size needed
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C.3 References 17. Keil, U., et al.
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C.3 References 50. Benjamin, E.J.,
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C.3 References 431. Statistisches B
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C.3 References 462. Bundeszentrale
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C.3 References 757. BSI-Standard 10
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C.3 References 790. Davis, C.E., et
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C.3 References 822. Hegenscheid, K.
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