Scientific Concept of the National Cohort (status ... - Nationale Kohorte

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Abbreviations DXA Dual-energy x-ray absorptiometry DZNE German Center for Neurodegenerative Diseases ECG Electrocardiogram/ electrocardiography EDCF Electronic data capture forms EDTA Ethylenediaminetetraacetic acid EEG Electroencephalogram EPC Epidemiological Planning Committee ERI Effort reward imbalance EU European Union FEV1 Forced expiratory volume in one second FPR False positive rate FVC Forced vital capacity GDR German Democratic Republic GEE Generalized estimating equations GIF Generalized impact fraction GIS Geographic information system GWAS Genome-wide associations studies HbA1c Hemoglobin A1c HFPEF Heart failure with preserved ejection fraction HFREF Heart failure with reduced ejection fraction HIV Human immunodeficiency virus HMGU Helmholtz Center Munich for Health and the Environment (Helmholtz Zentrum München – Deutsches Forschungszentrum für Gesundheit und Umwelt) HZI Helmholtz Center for Infection Research (Helmholtz-Zentrum für Infektionsforschung) IAB Institute for Employment Research (Institut für Arbeitsmarkt- und Berufsforschung) IADL Instrumental activities of daily living ICD International classification of diseases IDOM Instrument for database-assisted online recording for medication IPA Institute for Prevention and Occupational Medicine (Institut für Prävention und Arbeitsmedizin der Deutschen Gesetzlichen Unfallversicherung) IUF Leibniz Research Institute for Environmental Medicine IT Information technology JEM Job exposure matrix LADA Latent autoimmune diabetes in adults LIMS Laboratory Information Management System MDC Max-Delbrück Center for Molecular Medicine (Max-Delbrück-Centrum für Molekulare Medizin) XXII
MDOR Minimally detectable odds ratio MI Myocardial infarction MNC Mononuclear cells MRA Magnetic resonance angiography MRI Magnetic resonance imaging MRS Magnetic resonance spectroscopy XXIII Abbreviations NCT National Center for Tumor Diseases, Heidelberg (Nationales Centrum für Tumorerkrankungen, Heidelberg) NO Nitric oxide NIH US National Institutes of Health OGTT Oral glucose tolerance test OHIP Oral Health Impact Profile questionnaire PAD Peripheral arterial disease PAR Population attributable risk PBMC Peripheral blood mononuclear cells PR Public relations PST Plasma separation tube PTCA Percutaneous transluminal coronary angioplasty QALY Quality-adjusted life year QM Quality management RKI Robert Koch Institute RLS Restless legs syndrome RNA Ribonuleic acid RR Relative risk SAQ Self-assessment questionnaire SES Socioeconomic status SOPs Standard operating procedures SSK German Radiation Protection Commission (Deutsche Strahlenschutzkommission) SST Serum separation tube TICS Trier Inventory for Chronic Stress TMF Technologie- und Methodenplattform für die vernetzte medizinische Forschung e.V. TPR True positive rate UBA The Federal Environment Agency (Umweltbundesamt) VIF Variance inflation factor Study Acronyms ARIC study Atherosclerosis Risk in Communities study CARLA study Cardiovascular Disease, Living and Ageing in Halle study
Page 1: The National Cohort A prospective e
Page 4 and 5: Applicants Applicants Applicants Cl
Page 6 and 7: Applicants IV
Page 8 and 9: Executive Summary 2. The National C
Page 10 and 11: Executive Summary 3. Scientific aim
Page 12 and 13: Executive Summary essary to address
Page 14 and 15: Executive Summary 7. Examples for s
Page 16 and 17: Contents A.2.4 major areas of expos
Page 18 and 19: Contents A.3.8.2 Social security da
Page 20 and 21: Contents A.6.4.2 Minimally detectab
Page 22 and 23: Abbreviations C.2 mEThOdS fOr STATI
Page 26 and 27: Abbreviations CHS Cardiovascular He
Page 28 and 29: A.1 A.1 Introduction and overview a
Page 30 and 31: A.1 A.1 Introduction and overview s
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A.2 A.2. Scientific background and
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A.3 A.3 Study design ment instrumen
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A.3 A.3 Study design Table 3.2: Des
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A.3 A.3 Study design Table 3.3: Dis
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A.3 A.3 Study design the participan
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A.3 A.3 Study design with a prepare
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A.3 A.3 Study design rural areas, t
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A.3 A.3 Study design A.3.2 Baseline
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A.3 A.3 Study design Modules 70 Int
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A.3 A.3 Study design ovarian carcin
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A.3 A.3 Study design Table 3.5: Spe
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A.3 A.3 Study design depression and
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A.3 A.3 Study design to the extent
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A.3 A.3 Study design ers to vaccina
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A.3 A.3 Study design certain foods)
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A.3 A.3 Study design A short instru
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A.3 A.3 Study design ticipants and
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A.3 A.3 Study design a resting time
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A.3 A.3 Study design index, convent
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A.3 A.3 Study design Although the i
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A.3 A.3 Study design hemorrhages (0
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A.3 A.3 Study design genetics of BM
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A.3 A.3 Study design hand grip stre
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A.3 A.3 Study design Project title
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A.3 A.3 Study design diseases in va
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A.3 A.3 Study design associations,
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A.3 A.3 Study design Informed Conse
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A.3 A.3 Study design 6. Since being
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A.3 A.3 Study design the possible d
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A.3 A.3 Study design A.3.5 Collecti
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A.3 A.3 Study design Blood In addit
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A.3 A.3 Study design the anterior n
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A.3 A.3 Study design study. For exa
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A.3 A.3 Study design large-size sto
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A.3 A.3 Study design routinely prep
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A.3 A.3 Study design Subjects who m
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A.3 A.3 Study design A.3.6.3 reliab
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A.3 A.3 Study design In addition, a
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A.3 A.3 Study design Disease Questi
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A.3 A.3 Study design Data routinely
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A.3 A.3 Study design tial misclassi
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A.3 A.3 Study design � The KORA c
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A.3 A.3 Study design Table 3.16: Co
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A.3 A.3 Study design Table 3.17: Co
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A.4 A.4 Integrated Data Management
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A.5 A.5 Methods for quality assuran
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A.6 A.6 Planned statistical analyse
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A.6 A.6 Table Planned 6.4: Expected
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A.6 Planned statistical analyses an
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A.7 A.7 Ethical aspects logical/gen
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A.7 A.7 Ethical aspects The more ex
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A.7 A.7 Ethical aspects pants, trav
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A.7 A.7 Ethical aspects Data handli
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A.7 Table 7.2 Availability of ident
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A.7 A.7 Ethical aspects Should bios
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A.7 A.7 Ethical aspects ing finding
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A.7 A.7 Ethical aspects 206
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C.1 C.1 Annex: Description of the s
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C.1 C.1 Table Annex: 1: Cluster Des
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C.2 C.2 Annex: Methods for Statisti
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C.2 Table S6.5: Sample size needed
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C.3 References 17. Keil, U., et al.
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C.3 References 50. Benjamin, E.J.,
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C.3 References 85. Calle, E.E. and
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C.3 References 121. Walter, R., D.J
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C.3 References 155. Ross, R., Ather
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C.3 References 189. Ghiotto, F., et
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C.3 References 225. Schmidt, C.O.,
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C.3 References 260. Eussen, S., et
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C.3 References 294. McCrae, R.R. an
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C.3 References 327. Lynch, J.W., G.
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C.3 References 360. Mair, C., A.V.
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C.3 References 395. Lesourd, B., Nu
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C.3 References 431. Statistisches B
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C.3 References 462. Bundeszentrale
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C.3 References 494. Rammstedt, B. a
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C.3 References 526. Mack, F., et al
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C.3 References 560. Palatini, P., A
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C.3 References 590. Greenland, P.,
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C.3 References 623. Olin, A.C., et
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C.3 References 658. Pate, R.R., J.R
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C.3 References 691. Zenge, M.O., et
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C.3 References 727. Ryu, O.H., et a
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C.3 References 757. BSI-Standard 10
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C.3 References 790. Davis, C.E., et
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C.3 References 822. Hegenscheid, K.
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